Prevention of Teratogenesis in Pregnancies of Obese Rats by Vitamin E Supplementation

Autor: Martin Alcala, Victoria E. Bolado, Isabel Sánchez-Vera, Sonia Clapés, Francisco Dasí, Guillermo Sáez, Esther Carrera, Fabiola Alvarez-Gallego, Mary R. Loeken, Marta Viana

Publikováno v: Antioxidants, Vol 10, Iss 8, p 1173 (2021)

Congenital malformations are a common adverse outcome in pregnancies complicated by pregestational obesity, although the underlying mechanisms are still unrevealed. Our aim was to study the effect of oxidative stress in obesity-induced teratogenesis.

Externí odkaz: https://doaj.org/article/75ee6dd0efd84fae9dfef4171f499adf

This is the decade to find the solution for gestational diabetes mellitus screening and treatments

Autor: Mary R. Loeken, Robert S. Lindsay, Fidelma Dunne

Publikováno v: Diabetic Medicine. 38

The most common complication of pregnancy is diabetes. It is estimated that 1 in 6 pregnancies are affected (16.6%), with 84% of diabetic pregnancies being affected by Gestational Diabetes Mellitus (GDM)1 . More than 15 years ago, the evidence was cl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::04bf3e81331ba8625456e4fc34dd8d76
https://doi.org/10.1111/dme.14602

Mechanisms of Congenital Malformations in Pregnancies with Pre-existing Diabetes

Autor: Mary R. Loeken

Publikováno v: Curr Diab Rep

PURPOSE OF REVIEW: Fetuses of diabetic mothers are at increased risk for congenital malformations. Research in recent decades using animal and embryonic stem cell models has revealed many embryonic developmental processes that are disturbed by matern

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb37b849fafe654077fdecd91dbaf89f
https://pubmed.ncbi.nlm.nih.gov/32918152

A core outcome set for studies evaluating the effectiveness of prepregnancy care for women with pregestational diabetes

Autor: Eleni Anastasiou, Sander Galjaard, Declan Devane, Marie Todd, Harold W. de Valk, Valerie Smith, Fidelma Dunne, Michael Maresh, Aoife M. Egan, Angela Napoli, Mireille N M van Poppel, Eoin Noctor, Mary R. Loeken

Publikováno v: Egan, A M, Galjaard, S, Maresh, M J A, Loeken, M R, Napoli, A, Anastasiou, E, Noctor, E, de Valk, H W, van Poppel, M, Todd, M, Smith, V, Devane, D & Dunne, F P 2017, ' A core outcome set for studies evaluating the effectiveness of prepregnancy care for women with pregestational diabetes ', Diabetologia, pp. 1-7 . https://doi.org/10.1007/s00125-017-4277-4
Diabetologia
Diabetologia, 60(7), 1190-1196. Springer-Verlag

Aims/hypothesis The aim of this study was to develop a core outcome set (COS) for trials and other studies evaluating the effectiveness of prepregnancy care for women with pregestational (pre-existing) diabetes mellitus. Methods A systematic literatu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::571d55d3ffa084138833fefeb3aec912
https://doi.org/10.1007/s00125-017-4277-4

Lack of metformin effect on mouse embryo AMPK activity: implications for metformin treatment during pregnancy

Autor: Hyung-yul Lee, Mary R. Loeken, Dan Wei

Publikováno v: Diabetes/Metabolism Research and Reviews. 30:23-30

Background Adenosine monophosphate-activated protein kinase (AMPK) is stimulated in embryos during diabetic pregnancy by maternal hyperglycaemia-induced embryo oxidative stress. Stimulation of AMPK disrupts embryo gene expression and causes neural tu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c33cca3be8afdccd58721049e57d4792
https://doi.org/10.1002/dmrr.2451