Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Mary Pat Knadler"'
Autor:
Parag Garhyan, Amalia Gastaldelli, Helle Linnebjerg, Scott J. Jacober, Mary Pat Knadler, Elaine Watkins, Leona Plum‐Moerschel, Tim Heise, Ulrike Hoevelmann, Eric Chen Quin Lam, Niels Porksen
Publikováno v:
Diabetes, Obesity and Metabolism. 19:482-488
Aims Basal insulin peglispro (BIL) is a novel PEGylated basal insulin with a flat pharmacokinetic and glucodynamic profile and reduced peripheral effects, which results in a hepato-preferential action. In Phase 3 trials, patients with T1DM treated wi
Autor:
Mary Pat Knadler, William F. Annes, Amanda J. Long, Kathleen M. Hillgren, Jennifer Witcher, Y. Anne Pak, Malcolm I. Mitchell, Phillip Leese, Mosun Ayan-Oshodi
Publikováno v:
Drug Metabolism and Disposition
Despite peptide transporter 1 (PEPT1) being responsible for the bioavailability for a variety of drugs, there has been little study of its potential involvement in drug-drug interactions. Pomaglumetad methionil, a metabotropic glutamate 2/3 receptor
Autor:
John Michael Beals, Michael John de Veer, Mary Pat Knadler, Angela M. Siesky, Shun Li, Christopher J.H. Porter, M. Dodson Michael, Ryan John Hansen, Tri-Hung Nguyen, Kristina M. Campanale
Publikováno v:
Pharmaceutical Research
Purpose Determine the pharmacokinetics of insulin peglispro (BIL) in 5/6-nephrectomized rats and study the absorption in lymph duct cannulated (LDC) sheep. Methods BIL is insulin lispro modified with 20-kDa linear PEG at lysine B28 increasing the hyd
Autor:
Anthony T. Murphy, Jennifer A. Martin, Patricia Brown-Augsburger, Victor J. Wroblewski, Bernice Ellis, Mary Pat Knadler
Publikováno v:
Drug Metabolism and Disposition. 43:1477-1483
Basal insulin peglispro (BIL) comprises insulin lispro covalently bound to a 20-kDa polyethylene glycol (PEG) at lysine B28. The biologic fate of BIL and unconjugated PEG were examined in rats given a single 0.5-mg/kg i.v. or 2-mg/kg s.c. dose of BIL
Autor:
Theodore P. Ciaraldi, Eric Chen Quin Lam, Debra Armstrong, Helle Linnebjerg, Melvin J. Prince, Scott J. Jacober, Parag Garhyan, Niels Porksen, Robert R. Henry, Paivi Burke, Jeremy Pettus, Vikram Sinha, Namrata Bose, S. L. Choi, Sunder Mudaliar, Mary Pat Knadler
Publikováno v:
Diabetes Care. 37:2609-2615
OBJECTIVE We evaluated the endogenous glucose production (EGP) and glucose disposal rate (GDR) over a range of doses of basal insulin peglispro (BIL) and insulin glargine in healthy subjects. RESEARCH DESIGN AND METHODS This was a single-center, rand
Autor:
Michael J. Detke, Graeme Eisenhofer, Jill Chappell, Robert A. Dean, Mary Pat Knadler, D. Richard Lachno, Malcolm I. Mitchell, Beth A. Pangallo, Smriti Iyengar, Evelyn D. Lobo, Charles B. Nemeroff, Harry Haber, Michael J. Owens
Publikováno v:
Journal of Clinical Psychopharmacology. 34:9-16
Duloxetine selectively inhibits the serotonin (5-HT) and norepinephrine (NE) transporters (5-HTT and NET, respectively), as demonstrated in vitro and in preclinical studies; however, transporter inhibition has not been fully assessed in vivo at the a
Autor:
Parag Garhyan, Niels Porksen, Paivi Burke, S. L. Choi, Mary Pat Knadler, Robert R. Henry, Helle Linnebjerg, Vikram Sinha, Debra Armstrong, Eric Chen Quin Lam, Theodore P. Ciaraldi, Scott J. Jacober, Jeremy Pettus, Sunder Mudaliar, N. Bose, Melvin J. Prince
Publikováno v:
Diabetes, obesitymetabolism. 18
Aims Basal insulin peglispro (BIL), a novel PEGylated basal insulin with a large hydrodynamic size, has a delayed absorption and reduced clearance that prolongs the duration of action. The current study compared the effects of BIL and insulin glargin
Autor:
Philip W. Iversen, Joseph A. Jakubowski, James J. Starling, Lorrene A. Buckley, Mary Pat Knadler, Atsushi Sanbuissho
Publikováno v:
International Journal of Toxicology. 31:317-325
Prasugrel, a thienopyridine ADP receptor antagonist, is an orally administered prodrug requiring in vivo metabolism to form the active metabolite that irreversibly inhibits platelet activation and aggregation mediated by the P2Y12[sub 12] receptor. A
Autor:
Thomas L Hunt, Christine Y. Yu, Craig A. Sponseller, Baojin Zhu, David S. Small, Mary Pat Knadler, Stuart E. Campbell, Roger E. Morgan
Publikováno v:
Current Medical Research and Opinion. 28:187-194
Statins have been shown to impact international normalized ratio (INR) when coadministered with warfarin. The aim of this study was to assess the effect of pitavastatin compared with rosuvastatin on steady-state pharmacodynamics (PD) of warfarin by m
Publikováno v:
Clinical Pharmacokinetics. 50:281-294
Duloxetine, a potent reuptake inhibitor of serotonin (5-HT) and norepinephrine, is effective for the treatment of major depressive disorder, diabetic neuropathic pain, stress urinary incontinence, generalized anxiety disorder and fibromyalgia. Duloxe