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Autor:
Adrian J. Fretland, Mary Palacios, Dietrich Tuerck, Li J Yu, Jianguo Zhi, Micaela B. Reddy, Sazzad Hussain, Faye Vazvaei, Neil Parrott, Kelli J Glenn
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 46(8)
1. Idasanutlin (RG7388) is a potent p53-MDM2 antagonist currently in clinical development for treatment of cancer. The purpose of the present studies was to investigate the cause of marked decrease in plasma exposure after repeated oral administratio