Výsledky vyhledávání - "Mary P. Leatham"

Akademický článek

Uropathogenic Escherichia coli Metabolite-Dependent Quiescence and Persistence May Explain Antibiotic Tolerance during Urinary Tract Infection

Autor: Mary P. Leatham-Jensen, Matthew E. Mokszycki, David C. Rowley, Robert Deering, Jodi L. Camberg, Evgeni V. Sokurenko, Veronika L. Tchesnokova, Jakob Frimodt-Møller, Karen A. Krogfelt, Karen Leth Nielsen, Niels Frimodt-Møller, Gongqin Sun, Paul S. Cohen

Publikováno v: mSphere, Vol 1, Iss 1 (2016)

ABSTRACT In the present study, it is shown that although Escherichia coli CFT073, a human uropathogenic (UPEC) strain, grows in liquid glucose M9 minimal medium, it fails to grow on glucose M9 minimal medium agar plates seeded with ≤106 CFU. The ce

Externí odkaz: https://doaj.org/article/6497ab76beaa4d5e949dc9769acc0652

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Distinct roles for canonical and variant histone H3 lysine-36 in Polycomb silencing

Autor: Harmony R. Salzler, Vasudha Vandadi, Benjamin D. McMichael, John C. Brown, Sally A. Boerma, Mary P. Leatham-Jensen, Kirsten M. Adams, Michael P. Meers, Jeremy M. Simon, Robert J. Duronio, Daniel J. McKay, A. Gregory Matera

Publikováno v: Science Advances. 9

Polycomb complexes regulate cell type–specific gene expression programs through heritable silencing of target genes. Trimethylation of histone H3 lysine 27 (H3K27me3) is essential for this process. Perturbation of H3K36 is thought to interfere with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0ef3efe17bdc77106b4d76894e3433de
https://doi.org/10.1126/sciadv.adf2451

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Distinct roles for canonical and variant histone H3 lysine 36 in Polycomb silencing

Polycomb complexes regulate cell-type specific gene expression programs through heritable silencing of target genes. Trimethylation of histone H3 lysine 27 (H3K27me3) is essential for this process. Perturbation of H3K36 is thought to interfere with H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::77bcd1af26ca49165e118fea4af7e9d6
https://doi.org/10.1101/2022.10.11.511749

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A Simple In Vitro Gut Model for Studying the Interaction between Escherichia coli and the Intestinal Commensal Microbiota in Cecal Mucus

Autor: Tyrrell Conway, Matthew E. Mokszycki, Paul S. Cohen, Ying Zhang, Matthew E. Caldwell, Mary P. Leatham-Jensen, Jon Lund Steffensen, Karen A. Krogfelt

Publikováno v: Applied and Environmental Microbiology. 84

A novel in vitro gut model was developed to better understand the interactions between Escherichia coli and the mouse cecal mucus commensal microbiota. The gut model is simple and inexpensive while providing an environment that largely replicates the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a37cd3d0348548d9177193ceedc1c5be
https://doi.org/10.1128/aem.02166-18

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Escherichia coli EDL933 Requires Gluconeogenic Nutrients To Successfully Colonize the Intestines of Streptomycin-Treated Mice Precolonized with E. coli Nissle 1917

Autor: Jimmy Adediran, Paul S. Cohen, Matthew E. Mokszycki, Silvia A. C. Schinner, Tyrrell Conway, Mary P. Leatham-Jensen

Publikováno v: Infection and Immunity. 83:1983-1991

Escherichia coli MG1655, a K-12 strain, uses glycolytic nutrients exclusively to colonize the intestines of streptomycin-treated mice when it is the only E. coli strain present or when it is confronted with E. coli EDL933, an O157:H7 strain. In contr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd131f8d20628b2ed353e7f6a70d2d3b
https://doi.org/10.1128/iai.02943-14

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An Escherichia coli Nissle 1917 Missense Mutant Colonizes the Streptomycin-Treated Mouse Intestine Better than the Wild Type but Is Not a Better Probiotic

Autor: Paul S. Cohen, Jimmy Adediran, Tyrrell Conway, Mary P. Leatham-Jensen, Matthew E. Mokszycki, Jakob Frimodt-Møller, Linda J. Kenney, Karen A. Krogfelt, Krystyna Kazmierczak

Publikováno v: Infection and Immunity. 82:670-682

Previously we reported that the streptomycin-treated mouse intestine selected for two different Escherichia coli MG1655 mutants with improved colonizing ability: nonmotile E. coli MG1655 flhDC deletion mutants that grew 15% faster in vitro in mouse c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be4e5c00aa0263fac0f2e62ee00a1f5f
https://doi.org/10.1128/iai.01149-13

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The Streptomycin-Treated Mouse Intestine Selects Escherichia coli envZ Missense Mutants That Interact with Dense and Diverse Intestinal Microbiota

Autor: Megan E. Banner, Tyrrell Conway, Jimmy Adediran, Matthew E. Mokszycki, Mary P. Leatham-Jensen, Joyce E. Caughron, Karen A. Krogfelt, Jakob Frimodt-Møller, Paul S. Cohen

Publikováno v: Infection and Immunity. 80:1716-1727

Previously, we reported that the streptomycin-treated mouse intestine selected nonmotile Escherichia coli MG1655 flhDC deletion mutants of E. coli MG1655 with improved colonizing ability that grow 15% faster in vitro in mouse cecal mucus and 15 to 30

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2e2f2bb21b9de0b928cfbd2cf285518
https://doi.org/10.1128/iai.06193-11

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Precolonized Human Commensal Escherichia coli Strains Serve as a Barrier to E. coli O157:H7 Growth in the Streptomycin-Treated Mouse Intestine

Autor: Paul S. Cohen, Regino Mercado-Lubo, Mary P. Leatham, Steven M. Autieri, Swati Banerjee, Tyrrell Conway

Publikováno v: Infection and Immunity. 77:2876-2886

Different Escherichia coli strains generally have the same metabolic capacity for growth on sugars in vitro, but they appear to use different sugars in the streptomycin-treated mouse intestine (Fabich et al., Infect. Immun. 76:1143-1152, 2008). Here,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87f8ddc0a0694448282479d1619d7da4
https://doi.org/10.1128/iai.00059-09

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Glycogen and Maltose Utilization by Escherichia coli O157:H7 in the Mouse Intestine

Autor: Tyrrell Conway, Fatema Z. Chowdhury, Mary P. Leatham, Carsten Struve, James Hartline, Mathias Jorgensen, Rosalie Rodgers, Paul S. Cohen, Shari A. Jones, Karen A. Krogfelt

Publikováno v: Infection and Immunity. 76:2531-2540

In nature, the nutrients that support bacterial growth are rarely available continuously and are almost always present in limiting amounts, leading to the idea that bacterial existence is one of feast or famine (24). Others have proposed the existenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f37fd54cba3db339ea4d8021fff9d9e
https://doi.org/10.1128/iai.00096-08

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A Salmonella enterica Serovar Typhimurium Succinate Dehydrogenase/Fumarate Reductase Double Mutant Is Avirulent and Immunogenic in BALB/c Mice

Autor: Mary P. Leatham, Tyrrell Conway, Eric J. Gauger, Regino Mercado-Lubo, Paul S. Cohen

Publikováno v: Infection and Immunity. 76:1128-1134

Previously we showed that the tricarboxylic acid (TCA) cycle operates as a full cycle during Salmonella enterica serovar Typhimurium SR-11 peroral infection of BALB/c mice (M. Tchawa Yimga et al., Infect. Immun. 74:1130-1140, 2006). The evidence was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08ebd3eb19760d7f2e800063dbd94a21
https://doi.org/10.1128/iai.01226-07

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