Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Mary P. Latimer"'
Autor:
Mary N. Latimer, Lamario J. Williams, Gobinath Shanmugan, Bryce J. Carpenter, Mitchell A. Lazar, Pieterjan Dierickx, Martin E. Young
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
Abstract Circadian disruption increases cardiovascular disease (CVD) risk, through poorly understood mechanisms. Given that small RNA species are critical modulators of cardiac physiology/pathology, we sought to determine the extent to which cardiomy
Externí odkaz:
https://doaj.org/article/0fb22217c7f5420b847d9d0c876172f1
Autor:
Haifa Alsharif, Mary N. Latimer, Katherine C. Perez, Justin Alexander, Md Mostafizur Rahman, Anil K. Challa, Jeong-A. Kim, Sasanka Ramanadham, Martin Young, Sushant Bhatnagar
Publikováno v:
Metabolites, Vol 13, Iss 6, p 711 (2023)
Effective energy expenditure is critical for maintaining body weight (BW). However, underlying mechanisms contributing to increased BW remain unknown. We characterized the role of brain angiogenesis inhibitor-3 (BAI3/ADGRB3), an adhesion G-protein co
Externí odkaz:
https://doaj.org/article/6db45d1f199a4eb3b7390d521cd46ac2
Autor:
Ravi Sonkar, Ryan Berry, Mary N. Latimer, Sumanth D. Prabhu, Martin E. Young, Stuart J. Frank
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Circadian clocks regulate numerous biological processes, at whole body, organ, and cellular levels. This includes both hormone secretion and target tissue sensitivity. Although growth hormone (GH) secretion is time-of-day-dependent (increased pulse a
Externí odkaz:
https://doaj.org/article/1e631f784c0b42b58c6443225a64d935
Autor:
Mary N. Latimer, Martin E. Young
Publikováno v:
Cells, Vol 11, Iss 9, p 1494 (2022)
The cardiomyocyte circadian clock temporally governs fundamental cellular processes, leading to 24-h rhythms in cardiac properties (such as electrophysiology and contractility). The importance of this cell-autonomous clock is underscored by reports t
Externí odkaz:
https://doaj.org/article/72b4012e9821471a8a42f97942a05867
Autor:
Peggy R. Biga, Mary N. Latimer, Jacob Michael Froehlich, Jean-Charles Gabillard, Iban Seiliez
Publikováno v:
Biology Open, Vol 6, Iss 11, Pp 1720-1725 (2017)
The zebrafish (Danio rerio) remains the teleost fish of choice for biological investigations due to the vast array of molecular tools and resources available. To better understand the epigenetic regulation of autophagy, we utilized a primary myotube
Externí odkaz:
https://doaj.org/article/57e6cedc96254160adff297c7b0b5ad1
Publikováno v:
Frontiers in Endocrinology, Vol 9 (2018)
Methionine restriction (MR) has been studied extensively over the last 25 years for its role in altering metabolic hallmarks of disease. Animals subjected to MR, display changes in metabolic flexibility demonstrated by increases in energy expenditure
Externí odkaz:
https://doaj.org/article/d58cc4e6e6224713bc3150c0b1da9226
Publikováno v:
Psychopharmacology. 220:43-54
Rats will lever press to deliver nanolitre quantities of nicotine or the muscarinic agonist carbachol directly into the ventral tegmental area (VTA). The purpose of these experiments was to investigate further the characteristics of nicotine self-adm
Autor:
Patrícia A. Dombrowski, Suelen Lucio Boschen, Evellyn Claudia Wietzikoski, Mary P. Latimer, Mariza Bortolanza, Claudio Da Cunha, Duncan A. A. MacLaren, Philip Winn
Publikováno v:
Neurobiology of Learning and Memory. 94:229-239
The pedunculopontine tegmental nucleus (PPTg) targets nuclei in the basal ganglia, including the substantia nigra pars compacta (SNc), in which neuronal loss occurs in Parkinson’s disease, a condition in which patients show cognitive as well as mot
Publikováno v:
Brain Structure & Function
Excitotoxic lesions of posterior, but not anterior pedunculopontine tegmental nucleus (PPTg) change nicotine self-administration, consistent with the belief that the anterior PPTg (aPPTg) projects to substantia nigra pars compacta (SNC) and posterior
Autor:
Olivier Civelli, Mary P. Latimer, Hans-Peter Nothacker, Stewart D. Clark, H L Alderson, Philip Winn
Publikováno v:
Journal of Neurochemistry. 102:112-120
Urotensin II is a neuropeptide first isolated from fish and later found in mammals: where it has potent cardiovascular, endocrine and behavioral effects. In rat brain the urotensin II receptor (UII-R) is predominately expressed in the cholinergic neu