Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Mary P. Lambert"'
Autor:
Tomomi Kiyota, Masaru Yamamoto, Huangui Xiong, Mary P Lambert, William L Klein, Howard E Gendelman, Richard M Ransohoff, Tsuneya Ikezu
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6197 (2009)
The linkages between neuroinflammation and Alzheimer's disease (AD) pathogenesis are well established. What is not, however, is how specific immune pathways and proteins affect the disease. To this end, we previously demonstrated that transgenic over
Externí odkaz:
https://doaj.org/article/a173f8dd4d21409dbfd4273b9404191a
Autor:
William L. Klein, Wei Qin Zhao, Pascale N. Lacor, Hui Chen, Michael J. Quon, Grant A. Krafft, Mary P. Lambert
Publikováno v:
Journal of Biological Chemistry. 284:18742-18753
Accumulation of amyloid beta (Abeta) oligomers in the brain is toxic to synapses and may play an important role in memory loss in Alzheimer disease. However, how these toxins are built up in the brain is not understood. In this study we investigate w
Publikováno v:
CNS & Neurological Disorders - Drug Targets. 8:65-81
Individuals with early Alzheimers disease (AD) suffer from a selective and profound failure to form new memories. A novel molecular mechanism with implications for therapeutics and diagnostics is now emerging in which the specificity of AD for memory
Autor:
Kirsten L. Viola, Mary P. Lambert, Pauline T. Velasco, Wei Qin Zhao, Fernanda G. De Felice, Helena Decker, Theresa R. Bomfim, Marcelo N. N. Vieira, William L. Klein, Sergio T. Ferreira
Publikováno v:
Proceedings of the National Academy of Sciences. 106:1971-1976
Synapse deterioration underlying severe memory loss in early Alzheimer's disease (AD) is thought to be caused by soluble amyloid beta (Aβ) oligomers. Mechanistically, soluble Aβ oligomers, also referred to as Aβ-derived diffusible ligands (ADDLs),
Autor:
William L. Klein, Shi gao Yang, Xue ting Du, Ying Feng, Mary P. Lambert, Yu jiong Wang, Jun hua Zhang, Xi Zhang, Rui-tian Liu, Xiao-xia Sun, Min Zhao, Ji-Liang Li, Xiao ping Wang
Publikováno v:
FEBS Letters. 583:579-584
Increasing evidence indicates that beta-amyloid (Abeta) oligomers rather than monomers or fibrils are the major toxic agents that specifically inhibit synaptic plasticity and long-term potentiation (LTP) in Alzheimer's disease (AD). Neutralization of
Autor:
Paul Acton, Sara J. Fernandez, Gene G. Kinney, Diana Wu, William L. Klein, Mary P. Lambert, Elizabeth Chen-Dodson, Paul J. Shughrue, Eileen H. Bigio, Jasna Jerecic, Fernanda G. De Felice, Pauline T. Velasco, Pascale N. Lacor
Publikováno v:
Neurobiology of Aging. 29:1334-1347
Alzheimer's disease (AD) is characterized by presence of extracellular fibrillar A beta in amyloid plaques, intraneuronal neurofibrillary tangles consisting of aggregated hyperphosphorylated tau and elevated brain levels of soluble A beta oligomers (
Autor:
Caleb E. Finch, Kirsten L. Viola, Mary P. Lambert, Lei Chang, Jiaxin Yu, Todd E. Morgan, Brett A. Chromy, Duane L. Venton, William L. Klein, Grant A. Krafft
Publikováno v:
Journal of Neurochemistry. 79:595-605
In recent studies of transgenic models of Alzheimer's disease (AD), it has been reported that antibodies to aged beta amyloid peptide 1-42 (Abeta(1-42)) solutions (mixtures of Abeta monomers, oligomers and amyloid fibrils) cause conspicuous reduction
Autor:
Fernanda G. De Felice, William L. Klein, Sara J. Fernandez, Kirsten L. Viola, Mary P. Lambert, Pauline T. Velasco, Sergio T. Ferreira
Publikováno v:
Journal of Biological Chemistry. 282:11590-11601
Oxidative stress is a major aspect of Alzheimer disease (AD) pathology. We have investigated the relationship between oxidative stress and neuronal binding of Abeta oligomers (also known as ADDLs). ADDLs are known to accumulate in brain tissue of AD
Autor:
Pauline T. Velasco, Daliya Khuon, Pascale N. Lacor, Eileen H. Bigio, Yuesong Gong, Pamela L Shaw, Grant A. Krafft, Fernanda G. De Felice, Lei Chang, Sara J. Fernandez, Kirsten L. Viola, Mary P. Lambert, William L. Klein
Publikováno v:
Journal of Neurochemistry. 100:23-35
Amyloid beta (Abeta) immunotherapy for Alzheimer's disease has shown initial success in mouse models of Alzheimer's disease and in human patients. However, because of meningoencephalitis in clinical trials of active vaccination, approaches using ther
Autor:
Levina Tran, Mary P. Lambert, William L. Klein, Charles G. Glabe, Antonella Caccamo, Frank M. LaFerla, Salvatore Oddo
Publikováno v:
Journal of Biological Chemistry. 281:1599-1604
Accumulation of amyloid-β (Aβ) is one of the earliest molecular events in Alzheimer disease (AD), whereas tau pathology is thought to be a later downstream event. It is now well established that Aβ exists as monomers, oligomers, and fibrils. To st