Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Mary Nallin-Omstead"'
Autor:
Mary Nallin-Omstead, Gerald F. Bills, Jon D. Polishook, Victor J. Pecore, Richard L. Monaghan, Stanley L. Streicher
Publikováno v:
Canadian Journal of Botany. 73:925-931
Twenty-nine Nodulisporium strains isolated from material obtained worldwide were found to produce secondary metabolites as measured by HPLC. Analysis of incubation conditions resulted in the clustering of three solid fermentation conditions and the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::020637031940a2ab5e5d07a672a40d3c
https://doi.org/10.1139/b95-340
https://doi.org/10.1139/b95-340
Autor:
Gerald F. Bills, Marina Mojena, Keith C. Silverman, Leeyuan Huang, Claude Dufresne, Maria S. Meinz, Manuel Sanchez, Jackson B. Gibbs, James D. Bergstrom, John D. Karkas, Sheo B. Singh, Mary Nallin-Omstead, Russell B. Lingham, Guy H. Harris, Wendy H. Clapp
Publikováno v:
Canadian Journal of Botany. 73:898-906
Several potent inhibitors of squalence synthetase have been discovered. Zaragozic acid A is produced by several fungi; zaragozic acid B is produced by several strains of Sporormiella intermedia; zaragozic acids C, E, and F are produced by Leptodontid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7476c44aa960f618b56e68edc9a19f7
https://doi.org/10.1139/b95-337
https://doi.org/10.1139/b95-337
Autor:
Janet M. Sigmund, Isabel Martin, Olga Genilloud, Russell B. Lingham, Magda M. Gagliardi, Brian Heimbuch, Jackson B. Gibbs, Suzanne E. Gartner, Mary Nallin-Omstead, Gregory E. Koch, Sheo B. Singh, George M. Garrity, Carmen Cascales, Manuel Sanchez, Maria Teresa Diez, Charles F. Hirsch, Keith C. Silverman
Publikováno v:
Applied Microbiology and Biotechnology. 43:610-616
Actinoplanic acids A and B are macrocyclic polycarboxylic acids that are potent reversible inhibitors of farnesyl-protein transferase. Actinoplanic acids A and B were isolated from Actinoplanes sp. MA 7066 while actinoplanic acid B was isolated from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b81b5b0a30aa1a2878a3e81fc8a04cb
https://doi.org/10.1007/bf00164762
https://doi.org/10.1007/bf00164762
Autor:
E. Tracy Turner Jones, Sheo B. Singh, Jackson B. Gibbs, Mary Nallin-Omstead, Rosalind G. Jenkins, Russell B. Lingham, Gerald F. Bills, Michael Goetz, Keith C. Silverman
Publikováno v:
Tetrahedron Letters. 35:4693-4696
Ras (p21) protein is frequently found mutated in human cancers and must be farnesylated by farnesyl protein-transferase (FPTase) to achieve cell-transforming activity. Our continued search for inhibitors of FPTase as potential cancer chemotherapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5407a8b4b1ff457a2e053f3dfcccfb76
https://doi.org/10.1016/s0040-4039(00)76943-7
https://doi.org/10.1016/s0040-4039(00)76943-7
Autor:
Leeyuan Huang, Maria Teresa Diez-Matas, Claude Dufresne, Marina Mojena, Rosalind G. Jenkins, Kevin M. Byrne, Fernando Pelaez, Gerald F. Bills, Jon D. Polishook, Guy H. Harris, Wendy H. Clapp, Mary Nallin-Omstead, James D. Bergstrom
Publikováno v:
Mycological Research. 98:733-739
The search for squalene synthase inhibitors of microbial origin has resulted in the discovery of a new class of fungal metabolites, the zaragozic acids (squalestatins). During our survey of representatives of most major groups of fungi and filamentou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::603f1b631f1fa48f8d7f95e2641204d8
https://doi.org/10.1016/s0953-7562(09)81046-0
https://doi.org/10.1016/s0953-7562(09)81046-0
Autor:
Deborah L. Zink, E. Tracy Turner Jones, Gerald F. Bills, Maria S. Meinz, Gregory L. Helms, Mary Nallin-Omstead, Kenneth E. Wilson, Guy H. Harris
Publikováno v:
Tetrahedron Letters. 34:5235-5238
The isolation and structure elucidation of three members of a novel family of amino acid containing alkyl citrates, viridiofungins A (1), B (2) and C (3), are described. They are potent, broad spectrum antifungal agents and in vitro inhibitors of squ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b05ed461deecdcaefbb7c537bb3a0f5
https://doi.org/10.1016/s0040-4039(00)73961-x
https://doi.org/10.1016/s0040-4039(00)73961-x
Autor:
Ralph T. Mosley, Rosalind G. Jenkins, Jackson B. Gibbs, Suresh B. Singh, Gerald F. Bills, Mary Nallin-Omstead, Keith C. Silverman, Deborah L. Zink, Georg Albers-Schönberg, Russell B. Lingham, Michael A. Goetz, Jerrold M. Liesch
Publikováno v:
Tetrahedron. 49:5917-5926
Farnesyl-Protein transferase catalyses a post-translational modification of Ras that is obligatory for the cell transforming activity of this oncogene protein. The screening of natural products to identify inhibitors of this enzyme as a potential ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::794edd7ff728ff0532f28042fa0ff4f8
https://doi.org/10.1016/s0040-4020(01)87178-7
https://doi.org/10.1016/s0040-4020(01)87178-7
Publikováno v:
The Journal of Organic Chemistry. 58:1019-1024
The biosynthetic precursors of zaragozic acid A, a member of a new class of squalene synthase inhibitors, were determined. Washed cells of the producing culture, an unidentified sterile fungus, were supplemented with both 14 C- and 13 C-labeled sustr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eeaa3953813af6b8cf3df8207537ea8b
https://doi.org/10.1021/jo00057a010
https://doi.org/10.1021/jo00057a010
Autor:
Georg Albers-Schönberg, Suresh B. Singh, Keith C. Silverman, Michael A. Goetz, Russell B. Lingham, Jerrold M. Liesch, Gerald F. Bills, Ralph T. Mosley, Rosalind G. Jenkins, Jackson B. Gibbs, Mary Nallin-Omstead, Deborah L. Zink
Publikováno v:
ChemInform. 24
Farnesyl-Protein transferase catalyses a post-translational modification of Ras that is obligatory for the cell transforming activity of this oncogene protein. The screening of natural products to identify inhibitors of this enzyme as a potential ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb9eeeee10baa667e7bd64f1259017ae
https://doi.org/10.1002/chin.199343258
https://doi.org/10.1002/chin.199343258
Publikováno v:
ChemInform. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38158a5d713bebacba116cbb437d3fd2
https://doi.org/10.1002/chin.199322274
https://doi.org/10.1002/chin.199322274