Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Mary Mehlig"'
Autor:
Puja Sapra, Patricia Kraft, Mary Mehlig, Jennifer Malaby, Hong Zhao, Lee M. Greenberger, Ivan D. Horak
Publikováno v:
Haematologica, Vol 94, Iss 10 (2009)
Examination of the clinical utility of SN38 (10-hydroxy-7-ethyl-camptothecin), the active metabolite of CPT-11, has not been possible to date due to poor solubility of SN38. Here we evaluated the activity of EZN-2208, a water-soluble polyethyleneglyc
Externí odkaz:
https://doaj.org/article/abee49527c7742e2bd1749899e9e955e
Autor:
Fabio Pastorino, Ivan D. Horak, Domenico Ribatti, Mary Mehlig, Mirco Ponzoni, Lee M. Greenberger, Melissa Dumble, Patricia Kraft, Maoliang Wang, Puja Sapra
Publikováno v:
Angiogenesis
Topoisomerase I inhibitors down-regulate HIF-1α leading to tumor growth inhibition, but only while maintaining sustained levels of drug exposure. EZN-2208, a multi-arm 40 kDa pegylated, releasable SN38-drug conjugate, provides higher, longer lasting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::987e4b070750cb0875c175fc4957ccf4
http://europepmc.org/articles/PMC3155047
http://europepmc.org/articles/PMC3155047
Autor:
Hong Zhao, Mary Mehlig, Puja Sapra, Ivan Horak, Patricia Kraft, Jennifer Malaby, Lee M. Greenberger
Publikováno v:
Haematologica. 94:1456-1459
Examination of the clinical utility of SN38 (10-hydroxy-7-ethyl-camptothecin), the active metabolite of CPT-11, has not been possible to date due to poor solubility of SN38. Here we evaluated the activity of EZN-2208, a water-soluble polyethyleneglyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21f1c79c10759ac571196210e99e6e21
https://doi.org/10.3324/haematol.2009.008276
https://doi.org/10.3324/haematol.2009.008276
Autor:
Mary Mehlig, Clifford Longley, Ping Peng, Virna Borowski, Gerrit Borchard, Cy A. Stein, Jing Xia, Prasanna Reddy, Luba Benimetskaya, Hong Zhao, Jack M. Lipman, Yue Zhang
Publikováno v:
Journal of Controlled Release. 119:143-152
In order to overcome the problems of enzymatic degradation and short plasma half life, which can limit the delivery of antisense oligonucleotides, and the potential immuno-stimulatory effects of CpG motifs, we utilized a polyethylene glycol (PEG) tec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65a06fb8be4f949a9346766814ae01ed
https://doi.org/10.1016/j.jconrel.2006.12.021
https://doi.org/10.1016/j.jconrel.2006.12.021
Autor:
Zhihua Zhang, Eun Jang, Hsien-Ching Liu, Prakash Sai, Manickam Viswanathan, Gerald Petti, Clifford Longley, Xiguang Li, Virna Borowski, Karen Yang, Amartya Basu, Ping Peng, Stephen K. Youngster, Sam Liu, David Filpula, Maoliang Wang, Thomas Palm, Mary Mehlig, Hong Zhao, Lisa Hwang, Jack Hua, Yue Zhang
Publikováno v:
Bioconjugate Chemistry. 17:1447-1459
Arginine is an important metabolite in the normal function of several biological systems, and arginine deprivation has been investigated in animal models and human clinical trials for its effects on inhibition of tumor growth, angiogenesis, or nitric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f414284390dfc691d44aa7d7bb546ed
https://doi.org/10.1021/bc060198y
https://doi.org/10.1021/bc060198y
Autor:
Yun H. Choe, Dechun Wu, Yoany Gervacio, Charles D. Conover, Maksim Royzen, Virna Borowski, Richard B. Greenwald, Mary Mehlig
Publikováno v:
Journal of Controlled Release. 79:55-70
The synthesis of branched PEG (40,000) acids has been achieved using aspartic acid (Asp) and AspAsp dendrons. Complete conjugation of these dendritic acids with cytosine arabinoside (ara-C) was achieved by the use of spacers that allowed a greater se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a49df770d37645544a5c1b3047850b55
https://doi.org/10.1016/s0168-3659(01)00470-9
https://doi.org/10.1016/s0168-3659(01)00470-9
Autor:
Lee M. Greenberger, Clifford Longley, Puja Sapra, Jennifer Malaby, Hong Zhao, Ivan Horak, Patricia Kraft, Mary Mehlig
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 14(6)
Purpose: Clinical development of SN38, the active metabolite of camptothecin-11 (CPT-11), has been hampered due to its poor solubility. We have developed a novel polymer-drug conjugate, EZN-2208, made by linking SN38 with a multiarm polyethylene glyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2115488d00fb12c8ffbc106aa285d0f0
https://pubmed.ncbi.nlm.nih.gov/18347192
https://pubmed.ncbi.nlm.nih.gov/18347192
Autor:
Ping Peng, Manickam Viswanathan, Amartya Basu, Ahsen Janjua, Xiguang Li, Dechun Wu, Hong Zhao, Zhihua Zhang, John Zhou, Jun Liu, Magda Mendez, Maoliang Wang, Zhenfan Zhang, Jack Hua, Karen Yang, David Filpula, Gerald Petti, Ramesh Chintala, Virna Borowski, Clifford Longley, Thomas Palm, Mary Mehlig, Sam Liu, Ming-Ching Hsieh
Publikováno v:
Bioconjugate chemistry. 17(3)
Recombinant interferon-beta-1b (IFN-beta-1b) is used clinically in the treatment of multiple sclerosis. In common with many biological ligands, IFN-beta-1b exhibits a relatively short serum half-life, and bioavailability may be further diminished by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::632b990fb39c1979b6660e82ee0611b7
https://pubmed.ncbi.nlm.nih.gov/16704199
https://pubmed.ncbi.nlm.nih.gov/16704199
Autor:
Virna Borowski, Zhihua Zhang, Yang Wang, Deshan Yu, Tamara Minko, Ping Peng, Hong Zhao, Gerrit Borchard, Pooja Chandna, Mary Mehlig, Karen Yang, David Filpula, S. S. Dharap
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 110(1)
Antitumor effect of poly(ethylene glycol)-camptothecin conjugate (PEG-CPT) was studied in the nude mouse model of human colon cancer xenografts. The animals were treated intravenously with 15 mg/kg of camptothecin (CPT) or PEG-CPT conjugate at equiva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce926f03e69340bbc972400dc087a15
https://pubmed.ncbi.nlm.nih.gov/16271793
https://pubmed.ncbi.nlm.nih.gov/16271793
Autor:
Gerald Petti, Haleema Janjua, John Zhou, Jack Hua, Maoliang Wang, Mark Li, Magda Mendez, Clifford Longley, Ramesh Chintala, Zhenfan Zhang, Ming-Ching Hsieh, Hnin Phyu, Sam Liu, Ping Peng, Virna Borowski, David Filpula, Amartya Basu, Karen Yang, Mary Mehlig
Publikováno v:
Protein engineering. 16(10)
The utility of single-chain Fv proteins as therapeutic agents would be realized if the circulating lives of these minimal antigen-binding polypeptides could be both prolonged and adjustable. We have developed a general strategy for creating tailored
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0beb3e346e7aff5d1d1ecd2e6b900b94
https://pubmed.ncbi.nlm.nih.gov/14600206
https://pubmed.ncbi.nlm.nih.gov/14600206