Výsledky vyhledávání - "Mary Malo Cleary"

Inhibition of Activin Signaling Induces Pancreatic Epithelial Cell Expansion and Diminishes Terminal Differentiation of Pancreatic β-Cells

Autor: Ayse G. Kayali, Yingjie Si, Mary Malo Cleary, Guoxun Liu, Marcie Kritzik, You Qing Zhang, Nora Sarvetnick, Sandrine Dabernat, Yuzuru Eto

Publikováno v: Diabetes. 53:2024-2033

Activins regulate the growth and differentiation of a variety of cells. During pancreatic islet development, activins are required for the specialization of pancreatic precursors from the gut endoderm during midgestation. In this study, we probed the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbc42f7e9c5bc1a40465894ccc6509ca
https://doi.org/10.2337/diabetes.53.8.2024

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Target cell defense prevents the development of diabetes after viral infection

Autor: Mary Malo Cleary, Amy Maday, Akihiko Yoshimura, Deepika Balakrishna, Malin Flodström, Nora Sarvetnick

Publikováno v: Nature Immunology. 3:373-382

The mechanisms that regulate susceptibility to virus-induced autoimmunity remain undefined. We establish here a fundamental link between the responsiveness of target pancreatic beta cells to interferons (IFNs) and prevention of coxsackievirus B4 (CVB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53e0462d3114a26196b9fc0118a3b7fd
https://doi.org/10.1038/ni771

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Control of the Autoimmune Response by Type 2 Nitric Oxide Synthase

Autor: Mary Malo Cleary, Nora Sarvetnick, Soon Ha Kim, Malin Flodström, Fu-Dong Shi, Hans-Gustaf Ljunggren, Shyam Pakala

Publikováno v: The Journal of Immunology. 167:3000-3006

Immune defense against pathogens often requires NO, synthesized by type 2 NO synthase (NOS2). To discern whether this axis could participate in an autoimmune response, we immunized NOS2-deficient mice with the autoantigen acetylcholine receptor, indu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a4002337fe07996f285824b6354ad68
https://doi.org/10.4049/jimmunol.167.5.3000

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Interleukin-4 acts at the locus of the antigen-presenting dendritic cell to counter-regulate cytotoxic CD8+ T-cell responses

Autor: Ernest King, Cecile King, Nora Sarvetnick, Kaja Murali-Krishna, Rafi Ahmed, Regula Mueller Hoenger, Mary Malo Cleary

Publikováno v: Nature Medicine. 7:206-214

The mechanism underlying suppression of immune responses by interleukin-4 (IL-4) has remained unexplained. Here we show that the antigen-presenting dendritic cell is central to counter-regulation of autoimmune disease by IL-4. IL-4 acts at the locus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fcf1269ce4d89b91c608a745828eb08
https://doi.org/10.1038/84659

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