TCF21 hypermethylation regulates renal tumor cell clonogenic proliferation and migration

Autor: Saskia L. Gooskens, Timothy D. Klasson, Hendrik Gremmels, Ive Logister, Robert Pieters, Elizabeth J. Perlman, Rachel H. Giles, Mary M. van den Heuvel‐Eibrink

Publikováno v: Molecular Oncology, Vol 12, Iss 2, Pp 166-179 (2018)

We recently identified hypermethylation at the gene promoter of transcription factor 21 (TCF21) in clear cell sarcoma of the kidney (CCSK), a rare pediatric renal tumor. TCF21 is a transcription factor involved in tubular epithelial development of th

Externí odkaz: https://doaj.org/article/b8b625b9c7ee489e87f5fd790202c0ff

Therapy with low-dose azacitidine for MDS in children and young adults:a retrospective analysis of the EWOG-MDS study group

Autor: Mary M. van den Heuvel-Eibrink, Ayami Yoshimi, Owen P. Smith, Christian Flotho, Brigitte Strahm, Annamaria Cseh, Charlotte M. Niemeyer, Albert Català, Melchior Lauten, Lale Olcay, Michael C. Frühwald, Andreas E. Kulozik, Bernd Gruhn, M Suttorp, Markus Metzler, Toralf Bernig, Henrik Hasle, Ingrid Furlan, Barbara De Moerloose

Publikováno v: Cseh, A M, Niemeyer, C M, Yoshimi, A, Catala, A, Frühwald, M C, Hasle, H, van den Heuvel-Eibrink, M M, Lauten, M, De Moerloose, B, Smith, O P, Bernig, T, Gruhn, B, Kulozik, A E, Metzler, M, Olcay, L, Suttorp, M, Furlan, I, Strahm, B & Flotho, C 2016, ' Therapy with low-dose azacitidine for MDS in children and young adults : a retrospective analysis of the EWOG-MDS study group ', British Journal of Haematology, vol. 172, no. 6, pp. 930-6 . https://doi.org/10.1111/bjh.13915

Low-dose azacitidine is efficient and safe in the therapy of malignant myeloid disorders in adults but data in children are lacking. We present a retrospective analysis of 24 children and young adults with myelodysplastic syndrome (MDS) who received

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e912163413b938b6114b681b31b0aab
https://pure.au.dk/portal/da/publications/therapy-with-lowdose-azacitidine-for-mds-in-children-and-young-adults(0fb5a6aa-1bfe-4ae4-b994-e1f714d1deb5).html