Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Mary M. Sherman"'
Autor:
Mary M. Sherman, Paul M. Tarantino, Dennis N. Morrison, Chun-Han Lin, Ryan M. Parente, Bradford C. Sippy
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 133
The deuterium kinetic isotope effect has been used to affect the cytochrome P450 metabolism of the deuterated versions of substances. This study compares the pharmacokinetics of caffeine, a Generally Recognized As Safe food and beverage ingredient, v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3449d4d27d6ff74faf357eeb6dd9fe8a
https://pubmed.ncbi.nlm.nih.gov/35690181
https://pubmed.ncbi.nlm.nih.gov/35690181
Autor:
William Gallaway, Robert W. Ley, Francine S. Grant, Cesar Tio, Susan Petusky, Michael A. Pleiss, Darren B. Dressen, Mary M. Sherman, Lu Zhang, Dimitri Sarantakis, Semko Christopher M, Reinhardt Bernhard Baudy, Andrei W. Konradi, Susan Ashwell, Donna M. Huryn
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:1651-1654
A pro-drug strategy to identify orally efficacious VLA-4 antagonists is described. Potential pro-drugs were evaluated for their physical chemical characteristics and in vitro properties, including solubility, stability, permeability and plasma stabil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfdecbaca32d6714e423ac8aa609ba6e
https://doi.org/10.1016/j.bmcl.2004.01.062
https://doi.org/10.1016/j.bmcl.2004.01.062
Publisher Summary Very valuable resources for the discovery of biologically active agents are encoded combinatorial libraries of small molecules. A binary encoding protocol employing electrophoric molecular tags (ECLiPSe technology) has been develope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d69e49bcf999382ae74b668f6cf3ccc2
https://doi.org/10.1016/b978-012431165-7/50003-6
https://doi.org/10.1016/b978-012431165-7/50003-6
Autor:
J.S. Skotnicki, Zhang-Bao Xu, T. Wehr, Mila T. Du, Roy A. Black, C. E. Roth, Li Di, James M. Chen, Jeremy I. Levin, Michele A. Sharr, C.J March, R. Cowling, John F. DiJoseph, S. Skala, Kendall M. Mohler, Amy Sung, Mary M. Sherman, Frances C. Nelson, Loran M. Killar, G. Jin
Publikováno v:
Bioorganicmedicinal chemistry letters. 11(22)
Anthranilic acid derivatives bearing basic amines were prepared and evaluated in vitro and in vivo as inhibitors of MMP-1, MMP-9, MMP-13, and TACE. Piperazine 4u has been identified as a potent, selective, orally active inhibitor of MMP-9 and MMP-13.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d5e19bf3f666ee2e11c3aa0f30e660c
https://pubmed.ncbi.nlm.nih.gov/11677139
https://pubmed.ncbi.nlm.nih.gov/11677139
Autor:
Jehan F. Bagli, Albert John Molinari, Mark A. Ashwell, Eugene J. Trybulski, Mary M. Sherman, C.H. Park, C Palka, J.F Rogers, Thomas J. Caggiano, David K. Williams, Peter S. Chan
Publikováno v:
Bioorganicmedicinal chemistry letters. 10(8)
Ionizable groups were introduced onto the 10,11-dihydro-5 H -pyrrolo[2,1- c ][1,4]benzodiazepine scaffold of the vasopressin V 2 -antagonist WAY-VPA-985 in the search for molecules optimized for parenteral formulation. The synthesis and structure–a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::514736423647f5a02d7652275458c5f2
https://pubmed.ncbi.nlm.nih.gov/10782686
https://pubmed.ncbi.nlm.nih.gov/10782686
Autor:
Mary M. Sherman, Lu Zhang, Reinhardt Bernhard Baudy, William Gallaway, Francine S. Grant, Andrei W. Konradi, Dimitri Sarantakis, Semko Christopher M, Cesar Tio, Michael A. Pleiss, Susan Ashwell, Robert W. Ley, Donna M. Huryn, Darren B. Dressen, Susan Petusky
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:5449
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e0ec897667a80c7a3531d629f4328b5
https://doi.org/10.1016/j.bmcl.2004.07.006
https://doi.org/10.1016/j.bmcl.2004.07.006
Publikováno v:
Journal of the American Chemical Society. 103:5956-5959
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::720d3208c5511406693d7f6e14ace766
https://doi.org/10.1021/ja00409a076
https://doi.org/10.1021/ja00409a076
Autor:
C R Hutchinson, Mary M. Sherman
Publikováno v:
The Journal of Antibiotics. 39:1270-1280
The effect of known precursors, their fluorinated analogs, and biochemical inhibitors on the production of the polyether antibiotic, lasalocid A (1), by resting cells of Streptomyces lasaliensis was determined to study the biochemistry and regulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb85353495dad18787a920dc307fbd3c
https://doi.org/10.7164/antibiotics.39.1270
https://doi.org/10.7164/antibiotics.39.1270
Publikováno v:
Journal of the American Chemical Society. 103:5953-5956
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81c95237b5f522154361bd70076ab343
https://doi.org/10.1021/ja00409a075
https://doi.org/10.1021/ja00409a075
Publikováno v:
Phytochemistry. 19:1499-1501
A new triterpene has been isolated from the root bark of Ailanthus excelsa (Simaroubaceae) and identified as 3S,24S,25-trihydroxytirucall-7-ene.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::492ffa8261613f8e0d399f59491c165e
https://doi.org/10.1016/0031-9422(80)80204-4
https://doi.org/10.1016/0031-9422(80)80204-4