Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Mary M. Senior"'
Autor:
Brian M. Beyer, Vincent Madison, Eric M. Parker, Mckittrick Brian A, Daniel F. Wyss, William J. Greenlee, Corey Strickland, T. Nechuta, Johannes H. Voigt, John C. Hunter, Mary M. Senior, Andrew Stamford, Matthew E. Kennedy, Michael Czarniecki, Yu-Sen Wang, Elizabeth M. Smith
Publikováno v:
Journal of Medicinal Chemistry. 53:942-950
Fragment-based NMR screening, X-ray crystallography, structure-based design, and focused chemical library design were used to identify novel inhibitors for BACE-1. A rapid optimization of an initial NMR hit was achieved by a combination of NMR and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b051b98c57bda77146034e6e18e44c2d
https://doi.org/10.1021/jm901472u
https://doi.org/10.1021/jm901472u
Publikováno v:
International Journal of Peptide and Protein Research. 40:515-523
Two-dimensional NMR techniques were utilized to determine the secondary structural elements of endothelin-1 (ET-1), a potent vasoconstrictor peptide, and two of its point mutants, Met-7 to Ala-7 (ETM7A), and Asp-8 to Ala-8 (ETD8A) in acetic acid-d3/w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fc8e726c18317f21b7674777ccea246
https://doi.org/10.1111/j.1399-3011.1992.tb00435.x
https://doi.org/10.1111/j.1399-3011.1992.tb00435.x
Autor:
Liu Yi-Tsung, Frank Bennett, Viyyoor M. Girijavallabhan, F. George Njoroge, Lata Ramanathan, John Pichardo, Kevin X. Chen, S. Shane Taremi, Andrew Prongay, Brian M. Beyer, Corey Strickland, Rumin Zhang, Vincent Madison, Edwin Jao, Zhuyan Guo, Zhi Hong, Patricia C. Weber, Anil K. Saksena, Stephane L. Bogen, Srikanth Venkatraman, Rong-Sheng Yang, Nanhua Yao, Joseph E. Myers, Bruce A. Malcolm, Taisa Yarosh-Tomaine, Raymond G. Lovey, Richard N. Ingram, Ashok Arasappan, Thierry O. Fischmann, Mary M. Senior, Winifred W. Prosise
Publikováno v:
Journal of Synchrotron Radiation
Crystal structures of protease/inhibitor complexes guided optimization of the buried nonpolar surface area thereby maximizing hydrophobic binding. The resulting potent tripeptide inhibitor is in clinical trials.
The structures of both native and
The structures of both native and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a19c454d4a047e4eb08a7af266267ad8
http://europepmc.org/articles/PMC2394794
http://europepmc.org/articles/PMC2394794
Autor:
Nanhua Yao, Lata Ramanathan, Kevin X. Chen, Thierry O. Fischmann, Andrew Prongay, Corey Strickland, Mary M. Senior, Raymond G. Lovey, Richard N. Ingram, Bruce A. Malcolm, Viyyoor M. Girijavallabhan, Frank Bennett, Patricia C. Weber, Taisa Yarosh-Tomaine, John Pichardo, Anil K. Saksena, F. George Njoroge, Rong-Sheng Yang, Zhuyan Guo, Zhi Hong, Stephane L. Bogen, Srikanth Venkatraman, Ashok Arasappan, S. Shane Taremi, Brian M. Beyer, Rumin Zhang, Vincent Madison, Edwin Jao, Winifred W. Prosise, Yi-Tsung Liu, Joseph E. Myers
Publikováno v:
Journal of Medicinal Chemistry. 50:2310-2318
The structures of both the native holo-HCV NS3/4A protease domain and the protease domain with a serine 139 to alanine (S139A) mutation were solved to high resolution. Subsequently, structures were...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12ac27152dd419adc5be903b98a4f491
https://doi.org/10.1021/jm060173k
https://doi.org/10.1021/jm060173k
Publikováno v:
Biochemistry. 44:16594-16601
Accumulation of the cytotoxic 40- to 42-residue beta-amyloid peptide represents the primary pathological process in Alzheimer's disease (AD). BACE1 (beta-site APP cleaving enzyme 1) is responsible for the initial required step in the neuronal amyloid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16c701efb3e45e07cbcb80f530b5b2f6
https://doi.org/10.1021/bi051040o
https://doi.org/10.1021/bi051040o
Autor:
Daniel F. Wyss, F. George Njoroge, Brian M. Beyer, Mark A. McCoy, Yu-Sen Wang, Mary M. Senior, Ashok Arasappan
Publikováno v:
Journal of Medicinal Chemistry. 47:2486-2498
NMR-based screening of a customized fragment library identified 16 small-molecule hits that bind weakly (K(D) approximately 100 microM to 10 mM) to substrate binding sites of the NS4A-bound NS3 protease of the hepatitis C virus (HCV). Analogues for f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86343d02f4bc2ceecd5e485c1f8baab1
https://doi.org/10.1021/jm0305117
https://doi.org/10.1021/jm0305117
Publikováno v:
Proceedings of the National Academy of Sciences. 100:1645-1648
The stabilization of p53 against Mdm2-mediated degradation is an important event in DNA damage response. Initial models of p53 stabilization focused on posttranslational modification of p53 that would disrupt the p53–Mdm2 interaction. The N-termina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99cb464c592524d083742ae060921387
https://doi.org/10.1073/pnas.0334477100
https://doi.org/10.1073/pnas.0334477100
Autor:
Oswald Wilson, Mark E. Snow, Anne F. Frederick, Louise M. Perkins, Nicholas J. Murgolo, Stuart Black, Mary M. Senior, Yu-Sen Wang
Publikováno v:
Journal of Biomolecular NMR. 11:153-164
A set of high-resolution three-dimensional solution structures of the Src homology region-2 (SH2) domain of the growth factor receptor-bound protein-2 was determined using heteronuclear NMR spectroscopy. The NMR data used in this study were collected
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c19f028532d628bee4d5d00bae587aa3
https://doi.org/10.1023/a:1008250309874
https://doi.org/10.1023/a:1008250309874
Autor:
A.K. Ganguly, Taveras Arthur G, Robert M. Aust, Doll Ronald J, Mark E. Snow, W. Sisson, Birendra N. Pramanik, D. M. Delisle, Charles R. Kissinger, Shella A. Fuhrman, Mary M. Senior, Bancha Vibulbhan, Yu-Sen Wang, C.A. Evans, Paul Kirschmeier, Stacy W. Remiszewski, B.B. Bauer, Louise M. Perkins, V. Girijavallabhan, D. Cesarz, Robert A. Love, Joseph J. Catino, Eric C. Huang, C. Nash, Joan E. Brown, Larry Heimark, Donna Carr, Linda James, E. Villafranca, Anthony Tsarbopoulos, Edward L. Brown, S.E. Webber, Thomas F. Hendrickson, Stephen D. Liberles, J. del Rosario
Publikováno v:
Bioorganic & Medicinal Chemistry. 5:125-133
The nucleotide exchange process is one of the key activation steps regulating the ras protein. This report describes the development of potent, non-nucleotide, small organic inhibitors of the ras nucleotide exchange process. These inhibitors bind to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc28878387c5048a407d3b0e5a227d3a
https://doi.org/10.1016/s0968-0896(96)00202-7
https://doi.org/10.1016/s0968-0896(96)00202-7
Publikováno v:
Journal of Biological Chemistry. 269:16159-16162
Characterization of murine-human hybrid interferon-gamma (IFN-gamma) molecules suggests that substitution of the peptide connecting the A and B helices in human IFN-gamma with the murine sequence significantly blocks the protein's binding to the huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5b927c129a1b64ae24682886c953080
https://doi.org/10.1016/s0021-9258(17)33987-x
https://doi.org/10.1016/s0021-9258(17)33987-x