Mesenchymal Stem Cells Reduce Corneal Fibrosis and Inflammation via Extracellular Vesicle‐Mediated Delivery of miRNA

Autor: Golnar Shojaati, Irona Khandaker, Martha L. Funderburgh, Mary M. Mann, Rohan Basu, Donna B. Stolz, Moira L. Geary, Aurélie Dos Santos, Sophie X. Deng, James L. Funderburgh

Publikováno v: Stem Cells Translational Medicine, Vol 8, Iss 11, Pp 1192-1201 (2019)

Abstract Mesenchymal stem cells from corneal stromal stem cells (CSSC) prevent fibrotic scarring and stimulate regeneration of transparent stromal tissue after corneal wounding in mice. These effects rely on the ability of CSSC to block neutrophil in

Externí odkaz: https://doaj.org/article/acbdd15b352b43dd8c003f9f202aca2a

Mesenchymal Stem Cells Reduce Corneal Fibrosis and Inflammation via Extracellular Vesicle-Mediated Delivery of miRNA

Autor: Moira L. Geary, Irona Khandaker, Martha L. Funderburgh, Mary M. Mann, Aurélie Dos Santos, Sophie X. Deng, Donna B. Stolz, Rohan Basu, Golnar Shojaati, James L. Funderburgh

Publikováno v: Stem cells translational medicine, vol 8, iss 11
Stem Cells Translational Medicine, Vol 8, Iss 11, Pp 1192-1201 (2019)
Stem Cells Translational Medicine

Mesenchymal stem cells from corneal stromal stem cells (CSSC) prevent fibrotic scarring and stimulate regeneration of transparent stromal tissue after corneal wounding in mice. These effects rely on the ability of CSSC to block neutrophil infiltratio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dfeef0819af4109e70831d7bcd35be4
https://escholarship.org/uc/item/3p7936n9

Corneal stromal stem cells reduce corneal scarring by mediating neutrophil infiltration after wounding

Autor: Martha L. Funderburgh, James L. Funderburgh, Golnar Shojaati, Andrew Hertsenberg, Mary M. Mann, Yiqin Du

Publikováno v: PLoS ONE
PLoS ONE, Vol 12, Iss 3, p e0171712 (2017)

Corneal scarring limits vision for millions of individuals worldwide. Corneal transplantation (keratoplasty) is the standard of care for corneal opacity; however, it bears the risk of graft rejection and infection and is not universally available. St

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::398177a627fea71df7502ccb9b99fbfd
http://europepmc.org/articles/PMC5336198

Bioengineering Organized, Multilamellar Human Corneal Stromal Tissue by Growth Factor Supplementation on Highly Aligned Synthetic Substrates

Autor: Mary M. Mann, Yiqin Du, William R. Wagner, James L. Funderburgh, Enzhi Yang, Jian Wu

Publikováno v: Tissue Engineering Part A. 19:2063-2075

Recapitulating the microstructure of the native human corneal stromal tissue is believed to be a key feature in successfully engineering the corneal tissue. The stratified multilayered collagen fibril lamellae with orthogonal orientation determine th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4b4efdbe2a29e225c9164c43a859fe7
https://doi.org/10.1089/ten.tea.2012.0545

Human limbal biopsy–derived stromal stem cells prevent corneal scarring

Autor: Sheila M. Adams, Fatima N. Syed-Picard, Michael K. Burrow, Mary M. Mann, Yiqin Du, James L. Funderburgh, Martha L. Funderburgh, Andrew Hertsenberg, Kira L. Lathrop, Sayan Basu, David E. Birk

Publikováno v: Science Translational Medicine. 6

Conventional allograft therapy for corneal scarring is widespread and successful, but donor tissue is not universally available, and some grafts fail owing to rejection and complications such as endothelial failure. We investigated direct treatment o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42effb3660341a611d0a4863d89b5782
https://doi.org/10.1126/scitranslmed.3009644