Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Mary M. Kozma"'
Autor:
Patthara Kongsuphol, Huan Jia, Hoi Lok Cheng, Yue Gu, Bhuvaneshwari D/O Shunmuganathan, Ming Wei Chen, Sing Mei Lim, Say Yong Ng, Paul Ananth Tambyah, Haziq Nasir, Xiaohong Gao, Dousabel Tay, Seunghyeon Kim, Rashi Gupta, Xinlei Qian, Mary M. Kozma, Kiren Purushotorman, Megan E. McBee, Paul A. MacAry, Hadley D. Sikes, Peter R. Preiser
Publikováno v:
Communications Medicine, Vol 1, Iss 1, Pp 1-12 (2021)
Kongsuphol et al. develop a paper-based, vertical flow assay to detect SARS-CoV-2 neutralizing antibodies. The point-of-care assay has comparable performance to lab-based tests and provides results in 10 min.
Externí odkaz:
https://doaj.org/article/663f8b27aead4a418e60988c13e46a00
Autor:
Palur V Raghuvamsi, Nikhil K Tulsian, Firdaus Samsudin, Xinlei Qian, Kiren Purushotorman, Gu Yue, Mary M Kozma, Wong Y Hwa, Julien Lescar, Peter J Bond, Paul A MacAry, Ganesh S Anand
Publikováno v:
eLife, Vol 10 (2021)
The spike (S) protein is the main handle for SARS-CoV-2 to enter host cells via surface angiotensin-converting enzyme 2 (ACE2) receptors. How ACE2 binding activates proteolysis of S protein is unknown. Here, using amide hydrogen–deuterium exchange
Externí odkaz:
https://doaj.org/article/edbdeb7b5ce14846aca9ce972b3d86d3
Autor:
Nikhil K. Tulsian, Palur V. Raghuvamsi, Xinlei Qian, Gu Yue, Bhuvaneshwari D/O Shunmuganathan, Firdaus Samsudin, Wong Yee Hwa, Lin Jianqing, Kiren Purushotorman, Mary M. Kozma, Bei Wang, Julien Lescar, Cheng-I Wang, Ganesh S. Anand, Peter J. Bond, Paul A. MacAry
Previous studies on the structural relationship between human antibodies and SARS-CoV-2 have focused on generating static snapshots of antibody complexes with the Spike trimer. However, antibody-antigen interactions are dynamic, with significant bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5f52b056b592f4e77e5529cd1f6e3f8
https://doi.org/10.1101/2021.12.27.474251
https://doi.org/10.1101/2021.12.27.474251
Autor:
Hoi Lok Cheng, Peter R. Preiser, O Shunmuganathan, Hadley D. Sikes, Haziq Nasir, Patthara Kongsuphol, Mary M Kozma, Paul Ananth Tambyah, Bhuvaneshwari D, Megan E. McBee, Seunghyeon Kim, Xiaohong Gao, Say Yong Ng, Paul A. MacAry, Dousabel M Y Tay, Kiren Purushotorman, Rashi Gupta, Sing Mei Lim, Huan Jia, Xinlei Qian, Yue Gu, Ming Wei Chen
Publikováno v:
Communications Medicine, Vol 1, Iss 1, Pp 1-12 (2021)
Neutralizing antibodies (NAbs) prevent pathogens from infecting host cells. Detection of SARS-CoV-2 NAbs is critical to evaluate herd immunity and monitor vaccine efficacy against SARS-CoV-2, the virus that causes COVID-19. All currently available NA
Autor:
Firdaus Samsudin, Gu Yue, Wong Y Hwa, Peter J. Bond, Nikhil Kumar Tulsian, Palur Venkata Raghuvamsi, Ganesh S. Anand, Kiren Purushotorman, Mary M Kozma, Xinlei Qian, Julien Lescar, Paul A. MacAry
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
The Spike (S) protein is the main handle for SARS-CoV-2 to enter host cells through surface ACE2 receptors. How ACE2 binding activates proteolysis of S protein is unknown. Here, we have mapped the S:ACE2 interface and uncovered long-range allosteric
Autor:
Julien Lescar, Firdaus Samsudin, Palur Venkata Raghuvamsi, Paul A. MacAry, Wong Y Hwa, Ganesh S. Anand, Peter J. Bond, Kiren Purushotorman, Nikhil Kumar Tulsian, Xinlei Qian, Gu Yue, Mary M Kozma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a3424d95f93aa5a3680518a19dcc0e5
https://doi.org/10.7554/elife.63646.sa2
https://doi.org/10.7554/elife.63646.sa2
Autor:
Gu Y; Antibody Engineering Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore.; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; NUH-Cambridge Immune Phenotyping Centre, National University of Singapore, Singapore, Singapore., Shunmuganathan B; Antibody Engineering Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore.; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Qian X; Antibody Engineering Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore.; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Gupta R; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Tan RSW; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Kozma M; Antibody Engineering Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore., Purushotorman K; Antibody Engineering Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore.; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Murali TM; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Tan NYJ; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Preiser PR; Antimicrobial Resistance Interdisciplinary Research Group (AMR-IRG), Singapore-MIT Alliance in Research and Technology (SMART), Singapore, 138602, Singapore.; School of Biological Science (SBS), Nanyang Technological University (NTU), 60 Nanyang Dr, Singapore, 637551, Singapore., Lescar J; School of Biological Science (SBS), Nanyang Technological University (NTU), 60 Nanyang Dr, Singapore, 637551, Singapore.; NTU Institute of Structural Biology, Nanyang Technological University, 59 Nanyang Drive, Singapore, 636921, Singapore., Nasir H; Division of Infectious Disease, University Medicine Cluster, National University Hospital, Singapore, Singapore., Somani J; Division of Infectious Disease, University Medicine Cluster, National University Hospital, Singapore, Singapore., Tambyah PA; Division of Infectious Disease, University Medicine Cluster, National University Hospital, Singapore, Singapore., Smith KGC; NUH-Cambridge Immune Phenotyping Centre, National University of Singapore, Singapore, Singapore.; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, CB2 0AW, UK.; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK., Renia L; A*STAR Infectious Diseases Labs, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore., Ng LFP; A*STAR Infectious Diseases Labs, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Lye DC; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.; National Centre for Infectious Diseases (NCID), Singapore, Singapore.; Tan Tock Seng Hospital, Singapore, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Young BE; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.; National Centre for Infectious Diseases (NCID), Singapore, Singapore.; Tan Tock Seng Hospital, Singapore, Singapore., MacAry PA; Antibody Engineering Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore. micpam@nus.edu.sg.; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. micpam@nus.edu.sg.; NUH-Cambridge Immune Phenotyping Centre, National University of Singapore, Singapore, Singapore. micpam@nus.edu.sg.
Publikováno v:
Scientific reports [Sci Rep] 2023 Dec 09; Vol. 13 (1), pp. 21810. Date of Electronic Publication: 2023 Dec 09.
Autor:
Krishnananthasivam S; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Li H; College of Veterinary Medicine, China Agricultural University, Beijing, China.; Center for Infectious Disease Research, School of Medicine, Tsinghua University, Beijing, China., Bouzeyen R; Division of Experimental Medicine, University of California, San Francisco, USA., Shunmuganathan B; Life Sciences Institute, National University of Singapore, Singapore, Singapore., Purushotorman K; Life Sciences Institute, National University of Singapore, Singapore, Singapore., Liao X; National Clinical Laboratory on Tuberculosis, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing Chest Hospital, Capital Medical University, Beijing, P.R. China., Du F; National Clinical Laboratory on Tuberculosis, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing Chest Hospital, Capital Medical University, Beijing, P.R. China., Friis CGK; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Crawshay-Williams F; Molecular Immunity Unit, University of Cambridge, Department of Medicine, MRC Laboratory of Molecular Biology, Cambridge, UK., Boon LH; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Xinlei Q; Life Sciences Institute, National University of Singapore, Singapore, Singapore., Chan CEZ; National Centre for Infectious Diseases, Tan Tock Seng Hospital, Singapore, Singapore.; Defence Medical and Environmental Research Institute, DSO National Laboratories, Singapore, Singapore., Sobota R; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Kozma M; Life Sciences Institute, National University of Singapore, Singapore, Singapore., Barcelli V; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Wang G; National Clinical Laboratory on Tuberculosis, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing Chest Hospital, Capital Medical University, Beijing, P.R. China., Huang H; National Clinical Laboratory on Tuberculosis, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing Chest Hospital, Capital Medical University, Beijing, P.R. China., Floto A; Molecular Immunity Unit, University of Cambridge, Department of Medicine, MRC Laboratory of Molecular Biology, Cambridge, UK., Bifani P; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Javid B; Center for Infectious Disease Research, School of Medicine, Tsinghua University, Beijing, China. babak.javid@ucsf.edu.; Division of Experimental Medicine, University of California, San Francisco, USA. babak.javid@ucsf.edu., MacAry PA; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. micpam@nus.edu.sg.; Life Sciences Institute, National University of Singapore, Singapore, Singapore. micpam@nus.edu.sg.
Publikováno v:
NPJ vaccines [NPJ Vaccines] 2023 Sep 25; Vol. 8 (1), pp. 136. Date of Electronic Publication: 2023 Sep 25.
Autor:
Krishnananthasivam S; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Li H; College of Veterinary Medicine, China Agricultural University, Beijing, China.; Center for Infectious Disease Research, School of Medicine, Tsinghua University, Beijing, China., Bouzeyen R; Division of Experimental Medicine, University of California, San Francisco, USA., Shunmuganathan B; Life Sciences Institute, National University of Singapore, Singapore, Singapore., Purushotorman K; Life Sciences Institute, National University of Singapore, Singapore, Singapore., Liao X; National Clinical Laboratory on Tuberculosis, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing Chest Hospital, Capital Medical University, Beijing, P.R. China., Du F; National Clinical Laboratory on Tuberculosis, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing Chest Hospital, Capital Medical University, Beijing, P.R. China., Friis CGK; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Crawshay-Williams F; Molecular Immunity Unit, University of Cambridge, Department of Medicine, MRC Laboratory of Molecular Biology, Cambridge, UK., Boon LH; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Xinlei Q; Life Sciences Institute, National University of Singapore, Singapore, Singapore., Chan CEZ; National Centre for Infectious Diseases, Tan Tock Seng Hospital, Singapore, Singapore.; Defence Medical and Environmental Research Institute, DSO National Laboratories, Singapore, Singapore., Sobota R; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Kozma M; Life Sciences Institute, National University of Singapore, Singapore, Singapore., Barcelli V; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Wang G; National Clinical Laboratory on Tuberculosis, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing Chest Hospital, Capital Medical University, Beijing, P.R. China., Huang H; National Clinical Laboratory on Tuberculosis, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing Chest Hospital, Capital Medical University, Beijing, P.R. China., Floto A; Molecular Immunity Unit, University of Cambridge, Department of Medicine, MRC Laboratory of Molecular Biology, Cambridge, UK., Bifani P; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Javid B; Center for Infectious Disease Research, School of Medicine, Tsinghua University, Beijing, China. babak.javid@ucsf.edu.; Division of Experimental Medicine, University of California, San Francisco, USA. babak.javid@ucsf.edu., MacAry PA; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. micpam@nus.edu.sg.; Life Sciences Institute, National University of Singapore, Singapore, Singapore. micpam@nus.edu.sg.
Publikováno v:
NPJ vaccines [NPJ Vaccines] 2023 Aug 25; Vol. 8 (1), pp. 127. Date of Electronic Publication: 2023 Aug 25.