Antimitotic activity of DY131 and the estrogen-related receptor beta 2 (ERRβ2) splice variant in breast cancer

Autor: Mary M. Heckler, Rebecca B. Riggins, Aykut Üren, Susette C. Mueller, Shailaja D. Divekar, Aileen I. Fernandez, Rabindra Roy, Jordan Woodrick, Tizita Zewde Zeleke, Deanna M. Tiek, Alexander Farzanegan

Publikováno v: Oncotarget

Breast cancer remains a leading cause of cancer-related death in women, and triple negative breast cancer (TNBC) lacks clinically actionable therapeutic targets. Death in mitosis is a tumor suppressive mechanism that occurs in cancer cells experienci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83732807b63fdda4274448a06fadc289
https://doi.org/10.18632/oncotarget.9719

The induction of the p53 tumor suppressor protein bridges the apoptotic and autophagic signaling pathways to regulate cell death in prostate cancer cells

Autor: Paul Sirajuddin, Muhammad Umer Choudhry, Erika Parasido, Angiela Sivakumar, Lymor Ringer, Venkata Mahidhar Yenugonda, Iman Abdelgawad, Maria Laura Avantaggiati, Olga Rodriguez, Bhaskar Kallakury, Richard T. Lee, Adam S. Feldman, Chris Albanese, John H. Lynch, Sarah Waye, Mary M. Heckler, Anatoly Dritschilo, Richard G. Pestell, Aisha Naeem, Xuefeng Liu, Lucas Tricoli, Richard Schlegel, Chin-Lee Wu

Publikováno v: Oncotarget

// Lymor Ringer 1,* , Paul Sirajuddin 1,* , Lucas Tricoli 1,* , Sarah Waye 1 , Muhammad Umer Choudhry 1 , Erika Parasido 1 , Angiela Sivakumar 1 , Mary Heckler 1 , Aisha Naeem 1 , Iman Abdelgawad 1,6 , Xuefeng Liu 2 , Adam S. Feldman 3 , Richard J. L

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df7445818a27e8249781bb7af53871e4
http://europepmc.org/articles/PMC4279402

VMY-1-103 is a novel CDK inhibitor that disrupts chromosome organization and delays metaphase progression in medulloblastoma cells

Autor: Lymor Ringer, Chris Albanese, Jeffrey A. Toretsky, Aykut Üren, Olga Rodriguez, Milton L. Brown, Tobey J. MacDonald, Frank A. Suprynowicz, Anup K. Ghosh, Yichien Lee, Mary M. Heckler, Paul Sirajuddin, Venkata Mahidhar Yenugonda, Robert I. Glazer, Richard Schlegel

Medulloblastoma is the most prevalent of childhood brain malignancies, constituting 25% of childhood brain tumors. Craniospinal radiotherapy is a standard of care, followed by a 12mo regimen of multi-agent chemotherapy. For children less than 3 y of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90a7305b20b8b2d800ee8ca5a19ddfc2
https://europepmc.org/articles/PMC3367670/

Abstract 3570: Phospho-dependent regulation of ERRγ expression, transcriptional activity, and Tamoxifen resistance in ER+ breast cancer

Autor: Yuriy Gusev, Yue Wang, Mary M. Heckler, Rebecca B. Riggins, Subha Madhavan, Cara C. Schafer, Ye Tian, Salendra Singh, Hemang Thakor

Publikováno v: Cancer Research. 73:3570-3570

Selective estrogen receptor modulators (SERMs) such as Tamoxifen (TAM) can significantly improve breast cancer-specific survival for women with ER-positive (ER+) disease. However, resistance to TAM remains a major clinical problem. Estrogen-related r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f55ad879c8cf85a5ecdb2ab7f30eabc5
https://doi.org/10.1158/1538-7445.am2013-3570

The induction of the p53 tumor suppressor protein bridges the apoptotic and autophagic signaling pathways to regulate cell death in prostate cancer cells.

Autor: Ringer L; Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA., Sirajuddin P; Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA., Tricoli L; Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA., Waye S; Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA., Choudhry MU; Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA., Parasido E; Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA., Sivakumar A; Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA., Heckler M; Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA., Naeem A; Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA., Abdelgawad I; Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA. National Cancer Institute of Egypt, Cairo, Egypt., Liu X; Department of Pathology, Georgetown University Medical Center, Washington, DC, USA., Feldman AS; Massachusetts General Hospital, Boston, USA., Lee RJ; Massachusetts General Hospital, Boston, USA., Wu CL; Massachusetts General Hospital, Boston, USA., Yenugonda V; Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA., Kallakury B; Department of Pathology, Georgetown University Medical Center, Washington, DC, USA., Dritschilo A; Georgetown University Hospital, Washington, DC, USA., Lynch J; Georgetown University Hospital, Washington, DC, USA., Schlegel R; Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA. Department of Pathology, Georgetown University Medical Center, Washington, DC, USA., Rodriguez O; Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA., Pestell RG; Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA., Avantaggiati ML; Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA., Albanese C; Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA. Department of Pathology, Georgetown University Medical Center, Washington, DC, USA.

Publikováno v: Oncotarget [Oncotarget] 2014 Nov 15; Vol. 5 (21), pp. 10678-91.