Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Mary Lynne Hedley"'
Autor:
Radha Ramesh, Barbara S. Slusher, Gregory D. Wands, Min Yang, Thomas M. Luby, Mary Lynne Hedley, Christine M. Barbon
Publikováno v:
Cellular Immunology. 262:150-161
Cyclophosphamide in combination with immunotherapeutic approaches preferentially impinges on Treg activity and allows for robust generation of T cell effectors. Reduced dosages of cyclophosphamide are necessary to restrict its cytotoxic effects to th
Autor:
Blossom Marshall, Mary Lynne Hedley, Kathleen Beach, Patrick Nealon, John G. Gribben, Timothy D. Gilligan, Paul G. Richardson, David P. Ryan, Susana M. Campos, Lee M. Nadler, Ursula A. Matulonis, Donna Neuberg, Richard Boyajian, Robert G. Urban
Publikováno v:
Clinical Cancer Research. 11:4430-4436
Purpose: The carcinogen activator cytochrome P450 1B1 (CYP1B1) is expressed on almost all human tumors with rare expression on normal tissues. Anti-CYP1B1–specific T cells kill CYP1B1-expressing tumors, providing the rationale to examine CYP1B1 as
Autor:
Mary Lynne Hedley
Publikováno v:
Expert Opinion on Biological Therapy. 3:903-910
DNA expression vectors have the potential to be useful therapeutics for a wide variety of applications. However, development has been hindered by the lack of systems that provide protection from nuclease-based attack, enable cell or tissue localisati
Autor:
Mary Lynne Hedley, Geoffrey Cole, Ellen E. Sheets, Joseph A. Politch, Christopher P. Crum, Laila I. Muderspach, Michael A. Gold, Robert G. Urban, Peggy A. Crowley-Nowick
Publikováno v:
American Journal of Obstetrics and Gynecology. 188:916-926
Objective: The purpose of this study was to evaluate the safety of the administration of a bacterial expression plasmid encoding a 13 amino acid sequence that is highly homologous with human papillomavirus E7 within poly (lactide-co-glycolide) microp
Publikováno v:
Molecular Therapy. 7:401-408
Two polyethylene oxide-based delivery systems comprised of reacting PEG polymers were designed for the delivery of DNA expression vectors. The polymers are formulated with the DNA and injected into the muscle, wherein a crosslinked matrix forms in-si
Autor:
Mary Lynne Hedley, P Yin, Bijan Etemad-Moghadam, D Lee, U Ramstedt, T M Luby, H Chen, Nazneen Aziz
Publikováno v:
Gene Therapy. 10:348-355
alpha Melanocyte-stimulating hormone (alphaMSH) is a 13 amino acid peptide with potent anti-inflammatory effects. We created two DNA expression constructs (miniPOMC and pACTH1-17) that encode bioactive versions of the alphaMSH peptide, and tested the
Publikováno v:
Journal of Neuroimmunology. 125:23-29
α-Melanocyte Stimulating Hormone (αMSH) is a neuroimmunomodulatory peptide with remarkable anti-inflammatory properties. Daily or twice daily administration of the peptide reduces the symptoms of several inflammatory animal disease models and the p
Autor:
L Lunsford, Shikha P. Barman, Krishnendu Roy, U McKeever, Soo-Chang Song, Mary Lynne Hedley, P Chambers, Yung-Yueh Hsu, T Hao
Publikováno v:
Vaccine. 20:1524-1531
Parenteral administration of microparticle encapsulated DNA elicits immune responses to the encoded antigens. Experiments were performed to test whether the addition of certain lipophilic agents to such formulations enhanced the activity of a beta-ga
Publikováno v:
Journal of Controlled Release. 69:337-344
DNA can be formulated with synthetic polymers such as poly(lactide-co-glycolide) (PLG) to generate microparticles. Researchers have used either UV spectroscopy or fluorometry with PicoGreen((R)) dye to quantify PLG-encapsulated DNA. While the sensiti
Autor:
Mary Lynne Hedley
Publikováno v:
Advanced Drug Delivery Reviews. 44:195-207
Immune mediated inflammation that culminates in severe tissue necrosis is the hallmark of diseases that result from an inappropriate response to antigen. The inflammatory response becomes chronic when antigen is non-limiting and persists until the re