Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Mary Lou Augustine"'
Autor:
Andrew Orry, Erin E. Cawston, Mary Lou Augustine, Polo C.-H. Lam, Patrick M. Sexton, Ruben Abagyan, Eyup Akgün, Philip S. Portoghese, Maoqing Dong, Alicja M. Ball, Kaleeckal G. Harikumar, Laurence J. Miller
Publikováno v:
Journal of Biological Chemistry. 287:18618-18635
Allosteric binding pockets in peptide-binding G protein-coupled receptors create opportunities for the development of small molecule drugs with substantial benefits over orthosteric ligands. To gain insights into molecular determinants for this pocke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c63877d8d147a655586418b0eae3443c
https://doi.org/10.1074/jbc.m111.335646
https://doi.org/10.1074/jbc.m111.335646
Autor:
Leo T. O. Lee, Billy K. C. Chow, Kaleeckal G. Harikumar, Laurence J. Miller, Mary Lou Augustine
Complexes of secretin (SecR) and angiotensin 1a (Atr1a) receptors have been proposed to be functionally important in osmoregulation, providing an explanation for overlapping and interdependent functions of hormones that bind and activate different cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8476b51e4787183b2e3b34a7632a8365
http://hdl.handle.net/10722/232874
http://hdl.handle.net/10722/232874
Publikováno v:
Biochemistry. 30:8052-8059
In order to evaluate the contributions that histidine residues might play both in the catalytic activities of endonuclease V and in binding to nontarget DNA, the technique of oligonucleotide site directed mutagenesis was used to create mutations at e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f689436470c49659d92540614f6673d5
https://doi.org/10.1021/bi00246a025
https://doi.org/10.1021/bi00246a025
Autor:
Jennifer Beisterfeldt, Andrew P. Spicer, John A. McDonald, Anthony Calabro, Scott E. Klewer, Todd D. Camenisch, Steven W. Kubalak, Mary Lou Augustine, Tammy Brehm-Gibson
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b86363f1c6fecacfee843a1cfd64196f
https://doi.org/10.1533/9781845693121.177
https://doi.org/10.1533/9781845693121.177
Autor:
Steven W. Kubalak, Todd D. Camenisch, Mary Lou Augustine, Scott E. Klewer, Tammy Brehm-Gibson, John A. McDonald, Anthony Calabro, Jennifer Biesterfeldt, Andrew P. Spicer
Publikováno v:
The Journal of clinical investigation. 106(3)
We identified hyaluronan synthase-2 (Has2) as a likely source of hyaluronan (HA) during embryonic development, and we used gene targeting to study its function in vivo. Has2(-/-) embryos lack HA, exhibit severe cardiac and vascular abnormalities, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07e7f2cdaf82d1bb539f2b972a260f3e
https://pubmed.ncbi.nlm.nih.gov/10930435
https://pubmed.ncbi.nlm.nih.gov/10930435
Publikováno v:
The Journal of biological chemistry. 271(38)
We report the isolation of a novel mouse gene which encodes a putative hyaluronan synthase. The cDNA was identified using degenerate reverse transcriptase-polymerase chain reaction. Degenerate primers were designed based upon an alignment of the amin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78cced713cdcac9778ff89fcc0adc946
https://pubmed.ncbi.nlm.nih.gov/8798545
https://pubmed.ncbi.nlm.nih.gov/8798545
Publikováno v:
The Journal of biological chemistry. 270(40)
Although Micrococcus luteus UV endonuclease has been reported to be an 18-kDa enzyme with possible homology to the 16-kDa endonuclease V from bacteriophage T4 (Gordon, L. K., and Haseltine, W. A.(1980) J. Biol. Chem. 255, 12047-12050; Grafstrom, R. [
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3b4048d10ade36255232596d0fd8653
https://pubmed.ncbi.nlm.nih.gov/7559510
https://pubmed.ncbi.nlm.nih.gov/7559510
Autor:
R. Stephen Lloyd, Mary Lou Augustine
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 179:135-142
The DNA sequences associated with a very high-frequency, spontaneous deletion event have been determined to be two 11-base direct repeats which also contain an internal 6-base palindrome. A parental M13 replicative form (RF) DNA harboring DNA fragmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::765c1c74066d20fef16450c41cb074f6
https://doi.org/10.1016/0027-5107(87)90303-4
https://doi.org/10.1016/0027-5107(87)90303-4
Autor:
Mary Lou Augustine, R. Stephen Lloyd
Publikováno v:
Mutation Research/DNA Repair Reports. 165:89-100
Polyclonal antibodies have been raised against endonuclease V from the bacteriophage T4. This rabbit serum, from which endemic E. coli antibodies have been removed, reacts with a single protein from T4-infected E. coli with a molecular weight of 1607
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::151f47d8e5da2ed45da6b60a91bed98f
https://doi.org/10.1016/0167-8817(86)90064-7
https://doi.org/10.1016/0167-8817(86)90064-7
Autor:
Mary Lou Augustine, R. Stephen Lloyd
Publikováno v:
Proteins: Structure, Function, and Genetics. 6:128-138
Previous structure/function analyses of the DNA repair enzyme, T4 endonuclease V, have suggested that the extreme carboxyl portion of the enzyme is associated with pyrimidine dimer-specific binding (Recinos and Lloyd, and Stump and Lloyd, Biochemistr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb2f5124454f31ef92486193fec63bc4
https://doi.org/10.1002/prot.340060204
https://doi.org/10.1002/prot.340060204