Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Mary Liang"'
Autor:
Kristine S Ojala, Cassandra J Kaufhold, Mykenzie R Davey, Donggyun Yang, Mary Liang, Peter Wipf, Yomna Badawi, Stephen D Meriney
Publikováno v:
Human Molecular Genetics. 32:1901-1911
Spinal muscular atrophy (SMA) is a monogenic disease that clinically manifests as severe muscle weakness owing to neurotransmission defects and motoneuron degeneration. Individuals affected by SMA experience neuromuscular weakness that impacts functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8d4f5e4be897d59a49af15be06bee41
https://doi.org/10.1093/hmg/ddad019
https://doi.org/10.1093/hmg/ddad019
Autor:
Sarah A. Jaeggli, Haosheng Lin, Peter Onaka, Hubert Yamada, Tetsu Anan, Morgan Bonnet, Gregory Ching, Xiao-Pei Huang, Maxim Kramar, Helen McGregor, Garry Nitta, Craig Rae, Louis Robertson, Thomas A. Schad, Paul Toyama, Jessica Young, Chris Berst, David M. Harrington, Mary Liang, Myles Puentes, Predrag Sekulic, Brett Smith, Stacey R. Sueoka
Publikováno v:
Solar Physics. 297
TheDiffraction-Limited Near-Infrared Spectropolarimeter(DL-NIRSP) is one of the first-light instruments for the National Science Foundation’sDaniel K. Inouye Solar Telescope(DKIST). DL-NIRSP is an integral-field, dual-beam spectropolarimeter intend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc98846f06f3ed53df7ae93e431e15f6
https://doi.org/10.1007/s11207-022-02062-w
https://doi.org/10.1007/s11207-022-02062-w
Autor:
Carly S. Mazzone, Antonio Dominguez-Meijide, Jeffrey L. Brodsky, Mary Liang, Tiago F. Outeiro, Annette N. Chiang, David Newhouse, Peter Wipf, Nathan M. Kendsersky, Megan E. Yates, Patrick G. Needham, Caterina Masaracchia, Alexandra Manos-Turvey, Jennifer L. Goeckeler-Fried
Publikováno v:
Bioorganic & Medicinal Chemistry. 27:79-91
Over-expression of the Hsp70 molecular chaperone prevents protein aggregation and ameliorates neurodegenerative disease phenotypes in model systems. We identified an Hsp70 activator, MAL1-271, that reduces α-synuclein aggregation in a Parkinson’s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6e5c63d4a71c5b638613d360a3ee103
https://doi.org/10.1016/j.bmc.2018.11.011
https://doi.org/10.1016/j.bmc.2018.11.011
Autor:
Robert P. Hubbard, Aimee Szabo, Christopher Richards, Le Ellen Phelps, Heather K. Marshall, Kerry Gonzales, John R. Hubbard, Michael Knölker, Karl Newman, Mark Rast, Predrag Sekulic, Mary Liang, Colleen Donnelly, Christopher Gedrites, Brett Smith, Richard T. Summers, Christopher Foster, David Elmore, Sarah A. Jaeggli, Luke C. Johnson, Stephen B. Wampler, Brialyn Onodera, Thomas R. Rimmele, Isaac McQuillen, Joseph P. McMullin, Jeff Kuhn, Robert Rosner, David M. Harrington, Jean Benoit de Vanssay, Alisdair Davey, Stephen Guzzo, Bruce A. Cowan, Andrew Ferayorni, Stephanie S. Guzman, Steve Hegwer, Stacey R. Sueoka, Lukas M. Rimmele, Wolfgang Schmidt, Alfred G. de Wijn, Charles White, Friedrich Wöger, Erik M. Johansson, Jacobus M. Oschmann, Stephan R. Shimko, Tetsu Anan, Bryan K. Cummings, Oskar von der Lühe, Chriselle Ann Galapon, David C. Berst, Chen Liang, Mihalis Mathioudakis, Andrew Beard, Timothy R. Williams, Bret D. Goodrich, Simon C. Craig, Brett E. Simison, Myles M. Puentes, Stephen L. Keil, Haosheng Lin, Eric Cross, Thomas A. Schad, Erik Starman, Brian S. Gregory, Philip R. Goode, Christopher Mayer, Christian Beck, Donald L. Mickey, Roberto Casini, Arthur D. Eigenbrot, André Fehlmann, Louis Szabo, Alexandra Tritschler, Paul F. Jeffers, Mark Warner
Publikováno v:
Rimmele, T R, Warner, M, Keil, S L, Goode, P R, Knölker, M, Kuhn, J R, Rosner, R R, McMullin, J P, Casini, R, Lin, H, Wöger, F, von der Lühe, O, Tritschler, A, Davey, A, de Wijn, A, Elmore, D F, Fehlmann, A, Harrington, D M, Jaeggli, S A, Rast, M P, Schad, T A, Schmidt, W, Mathioudakis, M, Mickey, D L, Anan, T, Beck, C, Marshall, H K, Jeffers, P F, Oschmann, J M, Beard, A, Berst, D C, Cowan, B A, Craig, S C, Cross, E, Cummings, B K, Donnelly, C, de Vanssay, J B, Eigenbrot, A D, Ferayorni, A, Foster, C, Galapon, C A, Gedrites, C, Gonzales, K, Goodrich, B D, Gregory, B S, Guzman, S S, Guzzo, S, Hegwer, S, Hubbard, R P, Hubbard, J R, Johansson, E M, Johnson, L C, Liang, C, Liang, M, McQuillen, I, Mayer, C, Newman, K, Onodera, B, Phelps, L E, Puentes, M M, Richards, C, Rimmele, L M, Sekulic, P, Shimko, S R, Simison, B E, Smith, B, Starman, E, Sueoka, S R, Summers, R T, Szabo, A, Szabo, L, Wampler, S B, Williams, T R & White, C 2020, ' The Daniel K. Inouye Solar Telescope – Observatory Overview ', Solar Physics, vol. 295, no. 12, 172 . https://doi.org/10.1007/s11207-020-01736-7
We present an overview of the National Science Foundation’sDaniel K. Inouye Solar Telescope(DKIST), its instruments, and support facilities. The 4 m aperture DKIST provides the highest-resolution observations of the Sun ever achieved. The large ape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cae3d2aedb8dce89f37a06cde40c7715
https://pure.qub.ac.uk/en/publications/the-daniel-k-inouye-solar-telescope--observatory-overview(53af38b9-36ac-4c48-b702-0f5da5a26390).html
https://pure.qub.ac.uk/en/publications/the-daniel-k-inouye-solar-telescope--observatory-overview(53af38b9-36ac-4c48-b702-0f5da5a26390).html
Autor:
Stephen D. Meriney, Adolfo Garcia-Ocaña, Man Wu, Mary Liang, Yizhi Li, Tyler B. Tarr, Guillermo Valdomir, Peter Wipf, David Lacomis, Kristine S. Ojala
Publikováno v:
Annals of the New York Academy of Sciences. 1412:73-81
Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disorder caused by antibodies directed against the voltage-gated calcium channels that provide the calcium ion flux that triggers acetylcholine release at the neuromuscular junction. To study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::817771d960f6413e8b0a23f80fbc364a
https://doi.org/10.1111/nyas.13512
https://doi.org/10.1111/nyas.13512
Autor:
Stephen D. Meriney, Erika M. Gotway, Hayley V. White, Mary Liang, Christopher J. Meriney, Peter Wipf, Man Wu, Blake A. Boehm, Madeleine R. Wilcox, Kaylan Kerrigan, Michael Frasso, Jon W. Johnson
Publikováno v:
Neuropharmacology. 131
Voltage-gated calcium channels (VGCCs) are critical regulators of many cellular functions, including the activity-dependent release of chemical neurotransmitter from nerve terminals. At nerve terminals, the Cav2 family of VGCCs are closely positioned
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6c53e78296d81a576819ff181ddb394
https://pubmed.ncbi.nlm.nih.gov/29246857
https://pubmed.ncbi.nlm.nih.gov/29246857
Autor:
Joel S. Greenberger, Michael W. Epperly, Joshua R. Sacher, Tanja Krainz, Xiaolin Zhang, Renee Fisher, Peter Wipf, Mary Liang, Hong Wang, Song Li
Background/aim Mitochondrial-targeted gramicidin S (GS)-nitroxide, JP4-039, has been demonstrated to be a potent radiation mitigator, and safe over a wide dose range. In addition, JP4-039 has organ-specific effectiveness when locally applied. Materia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5dbdea035292a3b75ade9c39fb45770
https://europepmc.org/articles/PMC5267945/
https://europepmc.org/articles/PMC5267945/
Autor:
Peter Wipf, Tyler B. Tarr, David Lacomis, Guillermo Valdomir, Stephen D. Meriney, Mary Liang, Michael Frasso, Stephen W. Reddel
Publikováno v:
The Journal of Physiology. 592:3687-3696
Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disorder in which a significant fraction of the presynaptic P/Q-type Ca(2+) channels critical to the triggering of neurotransmitter release at the neuromuscular junction (NMJ) are thought to b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cde6d4919524745643496b13668f6fc4
https://doi.org/10.1113/jphysiol.2014.276493
https://doi.org/10.1113/jphysiol.2014.276493
Publikováno v:
Annals of the New York Academy of Sciences. 1275:85-91
Lambert-Eaton myasthenic syndrome (LEMS) causes neuromuscular weakness as a result of an autoimmune attack on the calcium channels that normally regulate chemical transmitter release at the neuromuscular junction. Currently there are limited treatmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::decef966ffbec614a8936757f5f4f5a9
https://doi.org/10.1111/nyas.12001
https://doi.org/10.1111/nyas.12001
Autor:
Vsevolod A. Peshkov, Mark E. Schurdak, Jennifer R. Grandis, Atefeh Garzan, Raffaele Colombo, Paul A. Johnston, John S. Lazo, Mary Liang, Zhuzhu Wang, Netanya I. Pollock, Donna M. Huryn, Yun Hua, Malabika Sen, Matthew G. LaPorte, Daniel P. Camarco, Peter Wipf
Publikováno v:
Bioorganic & medicinal chemistry letters, vol 26, iss 15
Structure–activity relationship studies of a 1,2,4-triazolo-[3,4-b]thiadiazine scaffold, identified in an HTS campaign for selective STAT3 pathway inhibitors, determined that a pyrazole group and specific aryl substitution on the thiadiazine were n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c83e5e253f3efef9119192486bbf98da
https://escholarship.org/uc/item/14h7n22g
https://escholarship.org/uc/item/14h7n22g