Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Mary L. Rodrick"'
Publikováno v:
Journal of the American College of Surgeons. 193:237-244
Research on the immune consequences of shock and trauma by multiple laboratories over more than 20 years has resulted in the following paradigm, which is currently accepted by most investigators in this field: serious traumatic or thermal injury is q
Publikováno v:
Shock. 11:153-159
For more than thirty years it has been apparent that serious injury in humans and experimental animals is associated with a decrease in immune functions dependent upon T cells, the principal cells involved in initiating adaptive immune responses. Thi
Autor:
Mary L. Rodrick
Publikováno v:
Sepsis. 3:235-238
For more than two decades it has been recognized that major traumatic or burn injury may result in a depressed immune response and that this depression may lead to increased susceptibility to life-threatening infections. This review addresses the eff
Autor:
Mary L. Rodrick, Christopher O'Sullivan, Ann Lyons, Diarmuid S. O'Riordain, Jane M. Doherty, John A. Mannick, John Kelly, Michael G. O'Riordain
Publikováno v:
Annals of Surgery. 225:530-543
OBJECTIVE: Patients with severe traumatic or burn injury and a mouse model of burn injury were studied early after injury to determine the relation of plasma endotoxin (lipopolysaccharide [LPS]) to the production of proinflammatory cytokines and subs
Autor:
Inna Saporoschetz, K. Collins, Miriam Nestor, Mary L. Rodrick, John A. Mannick, Paul Curley, M. V. Mendez
Publikováno v:
Gastroenterology. 110:583-588
The role of the cytokine interleukin 2 (IL-2) has long been recognized as central to normal immunologic function and defense against infection after burns and trauma, but little effort has been directed towards its role in acute pancreatitis (AP), wh
Autor:
Deric D. Schoof, John A. Mannick, M. V. Mendez, M. Nestor, Inna Saporoschetz, Mary L. Rodrick, A. Obando, Richard G Molloy, Diarmuid S. O'Riordain, René G Holzheimer
Publikováno v:
Journal of Surgical Research. 54:565-570
It has previously been shown by this laboratory that immunomodulation of thermally injured animals with low-dose interleukin-1 (IL-2) and indomethacin (Indo) improves survival following septic challenge. Lymphokine-activated killer (LAK) cells have b
Publikováno v:
Annals of Surgery. 214:253-263
It has been thought for some time that prostaglandin E2 (PGE2) released from activated monocytes/macrophages may contribute to the suppression of immunity seen after burns and major injury because PGE2 inhibits the activation of T lymphocytes. To cla
Publikováno v:
British Journal of Surgery. 77:401-404
Under anaesthesia, 129 8-week-old male A/J mice were subjected to a 25 per cent scald or sham burn and then resuscitated. They were divided at random into two groups. Mice from the first group were allocated into two groups. Mice from the first group
Autor:
K. M. Fox-Talbot, Henry A. Pitt, Einar Svendsen, Austin Leahy, Keith D. Lillemoe, Per Otto Hagen, H. Kim Lyerly, T. P. J. Hennessy, M. G. O’Riordain, F. B. V. Keane, J. F. Rothwell, M. J. Glimcher, Mary L. Rodrick, P. A. Lipsett, John G. Kennedy, Cathal J. Kelly, Eoin F. Gaffney, Henry Paul Redmond, S. M. Johnston, Liam O'Mahony, W. A. Tanner, Gregory Fulton, E. Coveney, T. Kilbaugh, Paul G. Horgan, Diarmuid S. O’Riordain, M. J. Staunton, W. J. Koch, John A. Mannick, David Bouchier-Hayes, C. Condon, A. F. Horgan, Ramila Philip, John Kelly, Gang Chen, Peter J. Kelly, Bryan M. Clary, J. R. Kasser, C. B. O’Suilleabhain, D. Bouchier-Hayes, Mark G. Davies, R. J. Lefkowitz, K. Mealy, E. J. Salih, Peter Neary
Publikováno v:
Irish Journal of Medical Science. 167:253-255
Publikováno v:
Shock (Augusta, Ga.). 19(6)
A mouse model of burn injury demonstrates increasing mortality to an infectious challenge in the form of cecal ligation and puncture (CLP) reaching a peak at 10 days after injury. Because it is widely believed that peritoneal mast cells play an impor