Výsledky vyhledávání - "Mary L, Stracke"

Sphingosine-1-phosphate initiates rapid retraction of pseudopodia by localized RhoA activation

Autor: Raejean Hermansen, Eunjin Koh, David D. Roberts, Mary L. Stracke, Elliott Schiffmann, Russell W. Bandle, Timothy Clair

Publikováno v: Cellular Signalling. 19:1328-1338

Lysophosphatidic acid (LPA) stimulates sphingosine-1-phosphate (S1P)-sensitive motility in NIH3T3 clone7 cells. S1P inhibits motility only when added to the bottom well of the Boyden chamber, suggesting that pseudopodia can respond to their microenvi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a504b93753bedb6a40f4751b9f9116a
https://doi.org/10.1016/j.cellsig.2007.01.005

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Autotaxin (ATX), a potent tumor motogen, augments invasive and metastatic potential of ras-transformed cells

Autor: Lance A. Liotta, Suk Woo Nam, Mary L. Stracke, Timothy Clair, Hoi Young Lee, Christina K Campo

Publikováno v: Oncogene. 19:241-247

Autotaxin (ATX), an exo-nucleotide pyrophosphatase and phosphodiesterase, was originally isolated as a potent stimulator of tumor cell motility. In order to study whether ATX expression affects motility-dependent processes such as invasion and metast

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c7a0804c8765f86de2740c85710ba43
https://doi.org/10.1038/sj.onc.1203263

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A sensitive screening assay for secreted motility-stimulating factors

Autor: Elliott Schiffmann, Mary L. Stracke, Suk Woo Nam, Timothy Clair, Lance A. Liotta

Publikováno v: Cell Motility and the Cytoskeleton. 46:279-284

Secreted motility-stimulating factors are often expressed and secreted at low concentrations that are difficult to detect by Northern or Western blot analysis. Autotaxin (ATX) is a tumor-secreted autocrine motility-stimulating factor that has been as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5d854897684fe9ca3c9834060c027caa
https://doi.org/10.1002/1097-0169(200008)46:4<279::aid-cm5>3.0.co

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Cyclocreatine inhibits stimulated motility in tumor cells possessing creatine kinase

Autor: Suk Woo Nam, Elisa C. Woodhouse, Lance A. Liotta, Peter T. Mulvaney, Rima Khaddurah-Daouk, Timothy Clair, Margaret O'Keefe, Mary L. Stracke, Elliott Schiffmann

Publikováno v: International Journal of Cancer. 78:46-52

Cyclocreatine (1-carboxymethyl-2-iminoimidazolidine), an analog of creatine and a substrate for creatine kinase (EC 2.7.3.2), inhibits the stimulated motility of tumor cells which possess creatine kinase. A2058-055 human melanoma cells, transfected w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5f4201b035ac2a568a4d948dfe429d44
https://doi.org/10.1002/(sici)1097-0215(19980925)78:1<46::aid-ijc9>3.0.co

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Autotaxin Is an Exoenzyme Possessing 5′-Nucleotide Phosphodiesterase/ATP Pyrophosphatase and ATPase Activities

Autor: Lance A. Liotta, Hoi Young Lee, Mary L. Stracke, Timothy Clair

Publikováno v: Journal of Biological Chemistry. 272:996-1001

Autotaxin (ATX) is an extracellular enzyme and an autocrine motility factor that stimulates pertussis toxin-sensitive chemotaxis in human melanoma cells at picomolar to nanomolar concentrations. This 125-kDa glycoprotein contains a peptide sequence i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5f691654d490645a8528a607685ae02
https://doi.org/10.1074/jbc.272.2.996

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Autotaxin, tumor motility-stimulating exophosphodiesterase

Autor: Timothy Clair, Lance A. Liotta, Mary L. Stracke

Publikováno v: Advances in Enzyme Regulation. 37:135-144

While nucleotides have a well-established role in intracellular metabolism, ATP and other nucleotides also have important extracellular roles in receptor-mediated signal transduction (34, 35). Extracellular or cell surface proteins capable of binding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40ba0c5a6eaa91767f8054f871621d19
https://doi.org/10.1016/s0065-2571(96)00017-9

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Stimulation of Tumor Cell Motility Linked to Phosphodiesterase Catalytic Site of Autotaxin

Autor: Sadie Aznavoorian, Peter T. Mulvaney, Hoi Young Lee, Mary L. Stracke, Timothy Clair, Elisa C. Woodhouse, Lance A. Liotta

Publikováno v: Journal of Biological Chemistry. 271:24408-24412

A family of extracellular type I phosphodiesterases has recently been isolated by cDNA cloning, but a physiological function linked to the phosphodiesterase active site has remained unknown. We now present evidence that the phosphodiesterase catalyti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2f2ee1c8c86611098967a55fd7ab3ab
https://doi.org/10.1074/jbc.271.40.24408

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Site-directed Mutagenesis of nm23-H1

Autor: Nicholas J. MacDonald, Mary L. Stracke, Patricia S. Steeg, Richard E. Manrow, José M.P. Freije

Publikováno v: Journal of Biological Chemistry. 271:25107-25116

We report the first correlation of Nm23 sequence and its tumor metastasis-suppressive capacity using site-directed mutagenesis and an in vitro tumor cell motility assay. MDA-MB-435 human breast carcinoma cells were transfected with a control expressi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::460375af86e60a028dfb60b8d1d4921b
https://doi.org/10.1074/jbc.271.41.25107

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Constitutive autotaxin transcription by Nmyc-amplified and non-amplified neuroblastoma cells is regulated by a novel AP-1 and SP-mediated mechanism and abrogated by curcumin

Autor: Lucia Cappabianca, Stefania Merolle, Andrew R. Mackay, Mary L. Stracke, Natalia Di Ianni, Marzia Ragone, Kimihiko Sano, Jonathan M. Horowitz, Alberto Gulino, Pierdomenico Ruggeri, Antonietta R. Farina

The motility, angiogenesis and metastasis-stimulating factor Autotaxin (Atx), over expressed by human neuroblastomas (NB), is constitutively expressed by human Nmyc-amplified SK-N-BE and non-Nmyc-amplified SH-SY5Y NB cells. Here, we characterise a no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c98a7e4bb0fc83234c425a5f05044ce
http://hdl.handle.net/11573/695910

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cDNA cloning of the human tumor motility-stimulating protein, autotaxin, reveals a homology with phosphodiesterases

Autor: Lance A. Liotta, Hoi Young Lee, J. Murata, A Arestad, Mary L. Stracke, Timothy Clair, Henry C. Krutzsch, Mark E. Sobel

Publikováno v: Journal of Biological Chemistry. 269:30479-30484

A human cDNA clone encoding autotaxin, a tumor cell motility-stimulating protein, reveals that this protein is an ecto/exo-enzyme with significant homology to the plasma cell membrane differentiation antigen PC-1. ATX is a 125-kDa glycoprotein, previ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::044ad1235601c725967d5582b9b922c5
https://doi.org/10.1016/s0021-9258(18)43838-0

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