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Akademický článek

Employment of a high throughput functional assay to define the critical factors that influence vaccine induced cross-variant neutralizing antibodies for SARS-CoV-2

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)

Abstract The scale and duration of neutralizing antibody responses targeting SARS-CoV-2 viral variants represents a critically important serological parameter that predicts protective immunity for COVID-19. In this study, we describe the development

Externí odkaz: https://doaj.org/article/274a4fa528b742699ad188ee670b344e

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Akademický článek

An anti-LpqH human monoclonal antibody from an asymptomatic individual mediates protection against Mycobacterium tuberculosis

Publikováno v: npj Vaccines, Vol 8, Iss 1, Pp 1-12 (2023)

Abstract Tuberculosis (TB) is an airborne disease caused by Mycobacterium tuberculosis (Mtb). Whilst a functional role for humoral immunity in Mtb protection remains poorly defined, previous studies have suggested that antibodies can contribute towar

Externí odkaz: https://doaj.org/article/b24451097c804d2ba5f67b2d5c67eea3

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Defining neutralization and allostery by antibodies against COVID-19 variants

Autor: Nikhil Tulsian, Palur Raghuvamsi, Xinlei Qian, Yue Gu, Bhuvaneshwari D/O Shunmuganathan, Firdaus Samsudin, Yee Hwa Wong, Jianqing Lin, Kiren Purushotorman, Mary Kozma, BEI WANG, Julien Lescar, Cheng-I Wang, Ravindra Gupta, Peter Bond, Paul MacAry

The changing landscape of mutations in the SARS-CoV-2 Spike protein is linked to the emergence of variants, immune-escape and reduced efficacy of the existing repertoire of anti-viral antibodies. A major factor that contributes to the functional acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bd2e04aa582f3a355e27b325f33512af
https://doi.org/10.21203/rs.3.rs-2465199/v1

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Defining Factors that Influence vaccine-induced, cross-variant neutralizing antibodies for SARS-CoV-2 in Asians

Autor: Mary Kozma, Siti Naqiah Amrun, David Lye

SummaryThe scale and duration of neutralizing antibody responses targeting SARS-CoV-2 viral variants represents a critically important serological parameter that predicts protective immunity for COVID-19. In this study, we present longitudinal data i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4ea5695c66a87f0c06c494400dd3a23c
https://doi.org/10.1101/2022.03.06.22271809

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Branched Chain Amino Acids Induce Apoptosis in Neural Cells without Mitochondrial Membrane Depolarization or CytochromecRelease: Implications for Neurological Impairment Associated with Maple Syrup Urine Disease

Autor: Nicholas D. Mazarakis, Jennifer M. Pocock, Catherine Sarraf, Ursula Felderhoff-Mueser, Deanna L. Taylor, Huseyin Mehmet, Mary Kozma, Pierre Rustin, Kirsty Greenwood, Philippe Jouvet, Umesh Joashi, A. David Edwards

Publikováno v: Molecular Biology of the Cell. 11:1919-1932

Maple syrup urine disease (MSUD) is an inborn error of metabolism caused by a deficiency in branched chain α-keto acid dehydrogenase that can result in neurodegenerative sequelae in human infants. In the present study, increased concentrations of MS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d3f3ec0544e794a58ce74f410065d8f
https://doi.org/10.1091/mbc.11.5.1919

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Poly(ADP ribose) polymerase cleavage precedes neuronal death in the hippocampus and cerebellum following injury to the developing rat forebrain

Autor: Deanna L. Taylor, Nicholas D. Mazarakis, Umesh Joashi, Mary Kozma, A. D. Edwards, Kirsty Greenwood, Huseyin Mehmet

Publikováno v: European Journal of Neuroscience. 11:91-100

Transient unilateral forebrain hypoxia-ischaemia (HI) in 14-day-old rats produces infarction and delayed neuronal death in the frontal cortex. Cell death can also be observed in regions distant from the primary injury, a phenomenon known as diaschisi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::be261a5e3bd7aa15c28a57313557fd2a
https://doi.org/10.1046/j.1460-9568.1999.00409.x

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Fas/CD95/APO-1 can function as a death receptor for neuronal cells in vitro and in vivo and is upregulated following cerebral hypoxic-ischemic injury to the developing rat brain

Autor: A. David Edwards, Umesh Joashi, B. Huseyin Mehmet, Dietger Stibenz, Kirsty Greenwood, Ursula Felderhoff-Mueser, Mary Kozma, Deanna L. Taylor

Publikováno v: Brain Pathol

Fas/CD95/Apo-1 is a cell surface receptor that transduces apoptotic death signals following activation and has been implicated in triggering apoptosis in infected or damaged cells in disease states. Apoptosis is a major mechanism of neuronal loss fol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05bb496b79f8cdb1d8fcac04562a737a
https://pubmed.ncbi.nlm.nih.gov/10668892

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Differential Effects of Nitric Oxide Species on Pc12 Cell Survival

Autor: Midori Kayahara, A. David Edwards, Kirsty Greenwood, Martin N. Hughes, Mary Kozma, Huseyin Mehmet

Publikováno v: Pediatric Research. 42:411-411

Background: Nitric oxide (NO•) is known to be both neurotoxic and neuroprotective. There are three redox-related species: neutral NO•, the nitroxyl anion (NO-) and the nitrosonium cation(NO+).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e1eba7188160fec9a1411df5addcaabe
https://doi.org/10.1203/00006450-199709000-00178

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