Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Mary Kay Francis"'
Publikováno v:
In Vitro Cellular & Developmental Biology - Animal. 51:730-738
Angiogenesis, or the formation of new blood vessels, is stimulated by angiogenic factors such as vascular endothelial growth factor (VEGF). Pigment epithelium-derived factor (PEDF) is a potent inhibitor of angiogenesis. To explore the mechanism by wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d084ddad01aa0288b098c2cf3cc7c7a5
https://doi.org/10.1007/s11626-015-9884-0
https://doi.org/10.1007/s11626-015-9884-0
Publikováno v:
Cancer Research. 65:2085-2088
Mutations in the three closely related RAS genes, HRAS, KRAS, and NRAS are among the most common mutations found in human cancer; reaching 50% in some types of cancer, such as colorectal carcinoma, and 10% in prostate cancers. The activated Ras prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46065fde5b4e5dc09dc714d9fbcf6398
https://doi.org/10.1158/0008-5472.can-04-4100
https://doi.org/10.1158/0008-5472.can-04-4100
Publikováno v:
Experimental Cell Research. 290:195-206
Cellular senescence is characterized by impaired cell proliferation. We have previously shown that, relative to the young counterpart, senescent WI-38 human fibroblasts display a decreased abundance of active phosphorylated ERK (p-ERK) in the nucleus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70e1a1bde1610fc76d954317b620d110
https://doi.org/10.1016/s0014-4827(03)00309-4
https://doi.org/10.1016/s0014-4827(03)00309-4
Autor:
Nancy Sawyer, Jennifer Mak, Catherine Blackwell, Jose B. Cibelli, Gabriela M. Baerlocher, Elizabeth A. Chavez, Mary Kay Francis, Michael D. West, Vincent J. Cristofalo, Robert Lanza, Peter M. Lansdorp, Michael Schertzer
Publikováno v:
Science. 288:665-669
The potential of cloning depends in part on whether the procedure can reverse cellular aging and restore somatic cells to a phenotypically youthful state. Here, we report the birth of six healthy cloned calves derived from populations of senescent do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::358d33e04970dee3f6142f06906313a2
https://doi.org/10.1126/science.288.5466.665
https://doi.org/10.1126/science.288.5466.665
Autor:
Vincent J. Cristofalo, Mitch O. Rotenberg, Mary Kay Francis, Vincent W. Coljee, Christian Sell, Maria Tresini
Publikováno v:
Journal of Cellular Biochemistry. 79:442-452
The EPC-1 (early population doubling level cDNA-1) gene, also known as pigment epithelium-derived factor, encodes a protein belonging to the serine protease inhibitor (serpin) superfamily that has been reported to inhibit angiogenesis and proliferati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b85c021397c1dde3fa5b99d46d4e59c
https://doi.org/10.1002/1097-4644(20001201)79:3<442::aid-jcb90>3.0.co
https://doi.org/10.1002/1097-4644(20001201)79:3<442::aid-jcb90>3.0.co
Publikováno v:
Critical Reviews in Eukaryotic Gene Expression. 8:43-80
Normal human fibroblasts exhibit a limited proliferative potential in culture. When populations are serially subcultured, they grow well initially, but ultimately reach a stage when they are no longer able to proliferate in response to mitogenic stim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::532ed605d0358a56e5d9017da79213e0
https://doi.org/10.1615/critreveukargeneexpr.v8.i1.30
https://doi.org/10.1615/critreveukargeneexpr.v8.i1.30
Publikováno v:
Journal of Biological Chemistry. 270:11502-11513
The modular ligand-binding domains of steroid receptors have been widely used to generate protein chimeras that are ligand dependent for activity. In a similar manner, we generated a series of conditionally active JunD and c-Fos proteins by fusing th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d15aa91799d5ae5ee017cfb56cfa06e1
https://doi.org/10.1074/jbc.270.19.11502
https://doi.org/10.1074/jbc.270.19.11502
Autor:
John M. Lehman, Mary Kay Francis
Publikováno v:
Journal of Cellular Biochemistry. 49:366-377
Murine embryonal carcinoma (EC) F9 cells do not produce interferon (IFN) at the protein or RNA level in response to inducing agents, while retinoic acid differentiated F9 cells do produce IFN. A probe was constructed spanning positions -104 to -39 of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::054566ea69ae6d9cbf6d0f7c1a7edd1c
https://doi.org/10.1002/jcb.240490407
https://doi.org/10.1002/jcb.240490407
Autor:
Jon J. Verrechio, James M. Leatherman, Mary Carmen Valenzano, Karen M. Snetselaar, Erika Rendon Huerta, Mary Kay Francis, Mantao Liu, David M. Smith, James M. Mullin, Christian Sell
Although ras mutations have been shown to affect epithelial architecture and polarity, their role in altering tight junctions remains unclear. Transfection of a valine-12 mutated ras construct into LLC-PK1renal epithelia produces leakiness of tight j
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6db955b11ad6313ee9402d4e51377f8d
https://europepmc.org/articles/PMC1289400/
https://europepmc.org/articles/PMC1289400/
Autor:
Samuel J. Balin, Vincent J. Cristofalo, Arthur K. Balin, Christine Meyer, Stacia Appel, Mary Kay Francis
Publikováno v:
The Journal of investigative dermatology. 122(5)
EPC-1/PEDF (early population doubling level cDNA-1/retinal pigmented epithelium-derived factor) is a single-copy, quiescence-specific gene that is transcribed into a 1.5 kb mRNA and then translated into a 50 kDa secreted protein that is a potent inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07365642ee351b66c7657369bf5a97d2
https://pubmed.ncbi.nlm.nih.gov/15140209
https://pubmed.ncbi.nlm.nih.gov/15140209