Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Mary Kathryn Sewell- Loftin"'
Autor:
Maranda Kramer, Allyson Criswell, Kamari Marzette, Emerson Cutcliffe, Mary Kathryn Sewell-Loftin
Publikováno v:
Mechanobiology in Medicine, Vol 2, Iss 4, Pp 100094- (2024)
The ovarian tumor microenvironment plays a critical yet is poorly understood role in the regulation of cancer cell behaviors including proliferation, migration, and response to chemotherapy treatments. Ovarian cancer is the deadliest gynecological ca
Externí odkaz:
https://doaj.org/article/e8e0bced8fae407fa1ae7aaddbbfbba8
Autor:
Molly Buckley, Maranda Kramer, Bronte Johnson, Gillian Huskin, Joel Berry, Mary Kathryn Sewell-Loftin
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Understanding the complex biomechanical tumor microenvironment (TME) is of critical importance in developing the next generation of anti-cancer treatment strategies. This is especially true in epithelial ovarian cancer (EOC), the deadliest o
Externí odkaz:
https://doaj.org/article/b716d870868346a59ce4a06cd270f492
Autor:
Bronte Miller Johnson, Allison McKenzie Johnson, Michael Heim, Molly Buckley, Bryan Mortimer, Joel L. Berry, Mary Kathryn Sewell-Loftin
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-16 (2023)
Abstract Background Angiogenesis, or the growth of new vasculature from existing blood vessels, is widely considered a primary hallmark of cancer progression. When a tumor is small, diffusion is sufficient to receive essential nutrients; however, as
Externí odkaz:
https://doaj.org/article/b96205f08dc049c69055a211f6f11344
Publikováno v:
Frontiers in Materials, Vol 10 (2023)
Ovarian cancer is the 5th most common and the deadliest gynecological cancer, with a 5-year survival rate of less than 50 percent. Most deaths due to ovarian cancer are caused by recurrent disease, which typically corresponds to an increase in chemor
Externí odkaz:
https://doaj.org/article/98e464c8a4a24bd59b47741a240d25f6
Autor:
Yichen Guo, Bronte Miller, Michael Heim, Ana Gutierrez-Garcia, Renata Jaskula-Sztul, Bin Ren, Mary Kathryn Sewell-Loftin
Publikováno v:
STAR Protocols, Vol 4, Iss 2, Pp 102177- (2023)
Summary: The cross talk between cancer cells and endothelial cells (ECs) within the tumor microenvironment plays a critical role in tumor progression, recurrence, and cancer stemness. Here, we present a protocol containing two in vitro approaches to
Externí odkaz:
https://doaj.org/article/2de2a34263f1440dae3181b72f13580f
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2022)
The endothelial cells that compose the vascular system in the body display a wide range of mechanotransductive behaviors and responses to biomechanical stimuli, which act in concert to control overall blood vessel structure and function. Such mechano
Externí odkaz:
https://doaj.org/article/f824ef47d1a944e1b29fad277d69df79
Autor:
Molly Buckley, Maranda Tidwell, Bronte Miller, Gillian Huskin, Joel Berry, Mary Kathryn Sewell-Loftin
Understanding the complex biomechanical tumor microenvironment (TME) is of critical importance in developing the next generation of anti-cancer treatment strategies. This is especially true in epithelial ovarian cancer (EOC), the deadliest of the gyn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::784c6062887ea37372fbb2910867679a
https://doi.org/10.21203/rs.3.rs-2444182/v1
https://doi.org/10.21203/rs.3.rs-2444182/v1
Autor:
Mehri Monavarian, Amal Taher Elhaw, Priscilla W. Tang, Zaineb Javed, Zainab Shonibare, Carly Bess Scalise, Rebecca Arend, Mohit Kumar Jolly, Mary Kathryn Sewell- Loftin, Nadine Hempel, Karthikeyan Mythreye
Publikováno v:
Seminars in cancer biology. 86(Pt 2)
The ascites ecosystem in ovarian cancer is inhabited by complex cell types and is bathed in an environment rich in cytokines, chemokines, and growth factors that directly and indirectly impact metabolism of cancer cells and tumor associated cells. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59b3fc8d36af883442195842707cd998
https://pubmed.ncbi.nlm.nih.gov/35259492
https://pubmed.ncbi.nlm.nih.gov/35259492
Autor:
Seth Bollenbecker, Zeelu Patel, Zeenia Punjani, Areesha Charania, Heli Patel, Alyssa Abbott, Kaitlyn Kunkle, Mary Kathryn Sewell-Loftin, Gregory Grossman, Karim Budhwani
Publikováno v:
Cancer Research. 83:P6-01
Background: Despite $90 billion in preclinical research and clinical trials every year, 90% of cancer clinical trials are unsuccessful. Thus, there is considerable interest in predicting clinical efficacy of preclinical formulations early in discover
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03a8376ee89717c98ec77921185c429d
https://doi.org/10.1158/1538-7445.sabcs22-p6-01-38
https://doi.org/10.1158/1538-7445.sabcs22-p6-01-38
Autor:
Zeelu H. Patel, Areesha A. Charania, Zeenia Punjani, Heli K. Patel, Mary Kathryn Sewell-Loftin, Mansoor N. Saleh, Karim I. Budhwani
Publikováno v:
Journal of Clinical Oncology. 40:e13500-e13500
e13500 Background: Despite recent advances in therapeutics, cancer remains the second leading cause of death worldwide. Next generation cancer models hold the promise of breaking this stranglehold. However, extracting adequate tissue for precision an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a204c341dcc1f67825eed528393a368
https://doi.org/10.1200/jco.2022.40.16_suppl.e13500
https://doi.org/10.1200/jco.2022.40.16_suppl.e13500