Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Mary K. Verzal"'
Autor:
Cele Abad-Zapatero, Anil Vasudevan, Clara I. Villamil, Kent D. Stewart, Tetsuro Oie, Mary K. Verzal, Stevan W. Djuric
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:4502-4505
The design and synthesis of indazolinone containing kinase inhibitors are reported. Regioisomers that showed profound potency variation in previously-reported isoindolinone and aminoindazole systems were surprisingly found to have similar potencies i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d70b7f4aef8839d746661ba8fe73f34
https://doi.org/10.1016/j.bmcl.2012.06.009
https://doi.org/10.1016/j.bmcl.2012.06.009
Autor:
Anil Vasudevan, Mary K. Verzal
Publikováno v:
Tetrahedron Letters. 46:1697-1701
An Ugi-deprotection–carbonylation/intramolecular amidation approach toward the synthesis of novel bicyclic and tricyclic macrolactams is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e4b478bd0b772dfbd1695808e04f6ac
https://doi.org/10.1016/j.tetlet.2005.01.063
https://doi.org/10.1016/j.tetlet.2005.01.063
Autor:
Mary K. Verzal, Anil Vasudevan
Publikováno v:
Synlett. :631-634
A novel methodology for the hydration of alkynes in superheated water using microwave irradiation is reported. Extension of this methodology to hydroamination of alkynes is also described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aa14e21107d462674e00e89bdb9b8a9
https://doi.org/10.1055/s-2004-817749
https://doi.org/10.1055/s-2004-817749
Aminopiperidine indazoles as orally efficacious melanin concentrating hormone receptor-1 antagonists
Autor:
Mathew M. Mulhern, Seble Wagaw, Brian D. Dayton, Philip R. Kym, Freeman Jennifer C, Sevan Brodjian, Kenneth M. Engstrom, Kennan C. Marsh, Anil Vasudevan, Andrew J. Souers, Robin Shapiro, Derek Wodka, Eugene N. Bush, Mary K. Verzal, Michael E. Brune, Lisa E. Hernandez, Lynch John K, Christine A. Collins, Ju Gao, Doug H. Falls
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(23)
The synthesis and biological evaluation of novel 3-amino indazole melanin concentrating hormone receptor-1 antagonists are reported, several of which demonstrated functional activity of less than 100nM. Compounds 19 and 28, two of the more potent com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65a734a9ddbbef91ceb1ff36e15f5666
https://pubmed.ncbi.nlm.nih.gov/16203136
https://pubmed.ncbi.nlm.nih.gov/16203136
Autor:
Jennifer Lee Che, Andrew J. Souers, Christine A. Collins, Doug H. Falls, Anil Vasudevan, Sujen Lai, Mary K. Verzal, Brian D. Dayton, Sevan Brodjian, Lisa E. Hernandez, Kennan C. Marsh, Christopher Blackburn, Brad J. Geddes, Derek Wodka, Thomas Daniels, Elizabeth K. Govek, Philip R. Kym
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(14)
The identification of a novel series of benzamide-containing MCHr1 antagonists is described. Compound 22 displayed moderate efficacy in a diet induced obesity mice model.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d826fc71bbe88017cd02a5a51d28ff2d
https://pubmed.ncbi.nlm.nih.gov/15950463
https://pubmed.ncbi.nlm.nih.gov/15950463
Autor:
Dariusz Wodka, Anil Vasudevan, Christopher A. Ogiela, Lisa E. Hernandez, Mary K. Verzal, Sevan Brodjian, Andrew J. Souers, Philip R. Kym, Christine A. Collins, Ju Gao, Kennan C. Marsh, Dennis G Fry, Brian D. Dayton
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(19)
The continued SAR investigation of 2-amino-8-alkoxy quinolines as melanin concentrating hormone receptor-1 (MCHr1) antagonists is reported. Prior hit-to-lead efforts resulted in the identification of 1 as a robust MCHr1 antagonist. Further delineatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cddc0c79f9cc7b8060de65e4bf1caaa7
https://pubmed.ncbi.nlm.nih.gov/15341943
https://pubmed.ncbi.nlm.nih.gov/15341943