Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Mary K. Leonard"'
Autor:
Natasha T Hill, Gabriel H Gracia-Maldonado, Mary K Leonard, Amanda R Harper, Kathleen L Tober, Tatiana M Oberyszyn, Madhavi P Kadakia
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107052 (2014)
ΔNp63α, a proto-oncogene, is up-regulated in non-melanoma skin cancers and directly regulates the expression of both Vitamin D receptor (VDR) and phosphatase and tensin homologue deleted on chromosome ten (PTEN). Since ΔNp63α has been shown to in
Externí odkaz:
https://doaj.org/article/00fff780688e45dda6eb15083c8cc448
Publikováno v:
Archives of Dermatological Research. 305:733-739
ΔNp63α maintains the proliferative potential of keratinocytes by inhibiting the transcription and nuclear localization of the tumor suppressor PTEN as shown earlier by our laboratory. The goal of this study was to define the mechanisms by which ΔN
Autor:
Madhavi P. Kadakia, Lawrence F. Drummy, Mary K. Leonard, Athanasios Bubulya, Christopher A. Vaiana, Richard A. Vaia, Rajesh R. Naik, Kristi M. Singh
Publikováno v:
Biomacromolecules. 12:3139-3146
Wound healing is a complex, multistep process that can be summarized into three stages, namely, hemostasis and inflammation, proliferation, and finally, tissue remodeling. Battlefield wound healing demands rapid hemostasis using clotting or cauterizi
Publikováno v:
Cell death and differentiation
The secosteroid hormone vitamin D3 (VD3) exerts its biological actions through its cognate receptor, the vitamin D receptor (VDR). Vitamin D3 and VDR have a key function in bone formation and keratinocyte differentiation, exert antiproliferative acti
Autor:
Joseph R, McCorkle, Mary K, Leonard, Susan D, Kraner, Eric M, Blalock, Deqin, Ma, Stephen G, Zimmer, David M, Kaetzel
Publikováno v:
Cancer genomicsproteomics. 11(4)
NME1 is a well-documented metastasis suppressor gene, with suppressor activity demonstrated across a wide spectrum of human cancers including melanoma and carcinomas of the breast, stomach and thyroid. A primary aim of the current study was to identi
Autor:
Mary K. Leonard, Gabriel H. Gracia-Maldonado, Kathleen L. Tober, Tatiana M. Oberyszyn, Amanda Harper, Madhavi P. Kadakia, Natasha T. Hill
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 9, p e107052 (2014)
PLoS ONE, Vol 9, Iss 9, p e107052 (2014)
ΔNp63α, a proto-oncogene, is up-regulated in non-melanoma skin cancers and directly regulates the expression of both Vitamin D receptor (VDR) and phosphatase and tensin homologue deleted on chromosome ten (PTEN). Since ΔNp63α has been shown to in
Publikováno v:
Cell cycle (Georgetown, Tex.). 12(9)
Loss of the tumor suppressor PTEN is observed in many human cancers that display increased chromosome instability and aneuploidy. The subcellular fractions of PTEN are associated with different functions that regulate cell growth, invasion and chromo
Autor:
V Payal, Madhavi P. Kadakia, Ramakrishna Kommagani, Mary K. Leonard, H N Shamma, Lindsey D. Mayo
Publikováno v:
Cell death and differentiation. 18(12)
ΔNp63α, implicated as an oncogene, is upregulated by activated Akt, part of a well-known cell survival pathway. Inhibition of Akt activation by phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and the presence of putative p63-binding
Autor:
Madhavi P. Kadakia, Ramakrishna Kommagani, Mary K. Leonard, Rose-Anne Romano, Satrajit Sinha, Stefanie Lewis
The p63 transcription factor has a pivotal role in epithelial morphogenesis. Multiple transcripts of the TP63 gene are generated because of alternative promoter usage and splicing. DeltaNp63alpha is the predominant isoform of p63 observed during epit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8c7220525dda890d2ee8bd30e9eb898
https://europepmc.org/articles/PMC2724606/
https://europepmc.org/articles/PMC2724606/
Publikováno v:
Cancer Research. 75:3907-3907
1α, 25-dihydroxyvitamin D3 (VD3) is a secosteriod that has been explored as an anti-cancer agent, but has also been shown to promote cell survival. Its receptor, Vitamin D Receptor (VDR), is a direct target of the oncogene ΔNp63α, which is overexp