Zobrazeno 1 - 6 of 6 pro vyhledávání: '"Mary K. Harrison"'
1
Correction for Adon et al., 'Cdk2 and Cdk4 Regulate the Centrosome Cycle and Are Critical Mediators of Centrosome Amplification in p53-Null Cells'
Autor: Harold I. Saavedra, Philipp Kaldis, Hiroaki Kiyokawa, Mary K. Harrison, Xiangbin Zeng, Arsene M. Adon, Stacy Sannem
Publikováno v: Molecular and cellular biology. 40(23)
The two mitotic centrosomes direct spindle bipolarity to maintain euploidy. Centrosome amplification—the acquisition of ≥3 centrosomes—generates multipolar mitoses, aneuploidy, and chromosome instability to promote cancer biogenesis. While much
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::293ad366cc9e2815910c6de1adaad0c6
https://pubmed.ncbi.nlm.nih.gov/19933848
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2
The Ras oncogene signals centrosome amplification in mammary epithelial cells through cyclin D1/Cdk4 and Nek2
Autor: Gustavo Leone, KA Carroll, Mary K. Harrison, Cynthia Timmers, FY Shaikh, Lewis A. Chodosh, Xiangbin Zeng, Arsene M. Adon, Harold I. Saavedra, Anthony J. Trimboli, Nidhi Sharma
Publikováno v: Oncogene. 29:5103-5112
Centrosome amplification (CA) contributes to carcinogenesis by generating aneuploidy. Elevated frequencies of CA in most benign breast lesions and primary tumors suggest a causative role for CA in breast cancers. Clearly, identifying which and how al
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6424b8e6d0b5f628d2733950ee36110
https://doi.org/10.1038/onc.2010.253
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3
The G1 phase Cdks regulate the centrosome cycle and mediate oncogene-dependent centrosome amplification
Autor: Arsene M. Adon, Mary K. Harrison, Harold I. Saavedra
Publikováno v: Cell Division
Cell Division, Vol 6, Iss 1, p 2 (2011)
Because centrosome amplification generates aneuploidy and since centrosome amplification is ubiquitous in human tumors, a strong case is made for centrosome amplification being a major force in tumor biogenesis. Various evidence showing that oncogene
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acb86d216b8308e157e80a6baade4b19
https://doi.org/10.1186/1747-1028-6-2
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4
Abstract 3048: High frequencies of centrosome amplification in MMTV-Her2/Neu pre-malignant mammary lesions and in Her2+ breast cancer cells suggest that centrosome amplification is involved in Her2-dependent breast cancer biogenesis
Autor: Mary K. Harrison, Harold I. Saavedra
Publikováno v: Cancer Research. 72:3048-3048
Centrosome amplification (CA) is a major force in cancer initiation and progression, as it generates aneuploidy and chromosome instability. Observations in breast tumors show that adenocarcinomas have a higher frequency of centrosome defects when com
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a0ba641223a0ce794fdb99a800f46c7d
https://doi.org/10.1158/1538-7445.am2012-3048
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5
Abstract 1467: Inhibition of Cdk4 radiosensitizes breast cancer cells by increasing PP2A levels, and decreasing Bad136 phosphorylation
Autor: Shannon Tucker-Kahn, Yuan Liu, Harold I. Saavedra, Katie R. Hagen, Sandra S. Zaky, Tongrui Liu, Xiangbin Zeng, Ruth O'Regan, Mary K. Harrison, Xingming Deng
Publikováno v: Cancer Research. 72:1467-1467
Treatment of breast cancers by targeting molecular markers associated with various subtypes has improved the outcome of breast cancer patients. Unfortunately, triple negative breast cancers lack these markers; missing estrogen and progesterone recept
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bb3094de45c2be08ddf52c949773c1fa
https://doi.org/10.1158/1538-7445.am2012-1467
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