Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Mary K McGahon"'
Autor:
Kevin Monaghan, Jennifer McNaughten, Mary K McGahon, Catriona Kelly, Daniel Kyle, Phaik Har Yong, J Graham McGeown, Tim M Curtis
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128359 (2015)
Retinal endothelial cell dysfunction is believed to play a key role in the etiology and pathogenesis of diabetic retinopathy. Numerous studies have shown that TRPV4 channels are critically involved in maintaining normal endothelial cell function. In
Externí odkaz:
https://doaj.org/article/f1f6d510271e4c8ca54ecd27467171dd
Autor:
Mary K McGahon, Janet M Yarham, Aideen Daly, Jasenka Guduric-Fuchs, Lyndsey J Ferguson, David A Simpson, Anthony Collins
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65809 (2013)
MicroRNAs (miRNAs) are single-stranded non-coding RNAs that negatively regulate target gene expression through mRNA cleavage or translational repression. There is mounting evidence that they play critical roles in heart disease. The expression of kno
Externí odkaz:
https://doaj.org/article/4787fbfae99a406297ff8f4556f0c2fb
Autor:
Michael O’Hare, Gema Esquiva, Mary K. McGahon, Jose Manuel Romero Hombrebueno, Josy Augustine, Paul Canning, Kevin S. Edgar, Peter Barabas, Thomas Friedel, Patrizia Cincolà, Jennifer Henry, Katie Mayne, Hannah Ferrin, Alan W. Stitt, Timothy J. Lyons, Derek P. Brazil, David J. Grieve, J. Graham McGeown, Tim M. Curtis
Publikováno v:
JCI Insight, Vol 7, Iss 18 (2022)
Loss of retinal blood flow autoregulation is an early feature of diabetes that precedes the development of clinically recognizable diabetic retinopathy (DR). Retinal blood flow autoregulation is mediated by the myogenic response of the retinal arteri
Externí odkaz:
https://doaj.org/article/a8eb7a938da94f0fbc793be40b8dc476
Autor:
Michael O’Hare, Gema Esquiva, Mary K. McGahon, Jose Manuel Romero Hombrebueno, Josy Augustine, Paul Canning, Kevin S. Edgar, Peter Barabas, Thomas Friedel, Patrizia Cincolà, Jennifer Henry, Katie Mayne, Hannah Ferrin, Alan W. Stitt, Timothy J. Lyons, Derek P. Brazil, David J. Grieve, J. Graham McGeown, Tim M. Curtis
Publikováno v:
O'Hare, M, Esquiva, G, McGahon, M K, Hombrebueno, J M R, Augustine, J, Canning, P, Edgar, K S, Barabas, P, Friedel, T, Cincolà, P, Henry, J, Mayne, K, Ferrin, H, Stitt, A W, Lyons, T J, Brazil, D P, Grieve, D J, McGeown, J G & Curtis, T M 2022, ' Loss of TRPV2-mediated blood flow autoregulation recapitulates diabetic retinopathy in rats ', JCI insight, vol. 7, no. 18, e155128 . https://doi.org/10.1172/jci.insight.155128
Loss of retinal blood flow autoregulation is an early feature of diabetes that precedes the development of clinically recognizable diabetic retinopathy (DR). Retinal blood flow autoregulation is mediated by the myogenic response of the retinal arteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e026e1b17c412483c93ec37feda6a413
https://pubmed.ncbi.nlm.nih.gov/36134661
https://pubmed.ncbi.nlm.nih.gov/36134661
Autor:
Peter, Barabas, Josy, Augustine, José A, Fernández, J Graham, McGeown, Mary K, McGahon, Tim M, Curtis
Publikováno v:
Current topics in membranes. 85
Retinal pressure autoregulation is an important mechanism that protects the retina by stabilizing retinal blood flow during changes in arterial or intraocular pressure. Similar to other vascular beds, retinal pressure autoregulation is thought to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a7981699e7fc2705531dc8e788a2ef6b
https://pubmed.ncbi.nlm.nih.gov/32402639
https://pubmed.ncbi.nlm.nih.gov/32402639
Autor:
J. Graham McGeown, Mary K. McGahon, José A Fernández, Josy Augustine, Tim M. Curtis, Peter Barabas
Retinal pressure autoregulation is an important mechanism that protects the retina by stabilizing retinal blood flow during changes in arterial or intraocular pressure. Similar to other vascular beds, retinal pressure autoregulation is thought to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9c66070a3a0e716df7162965afc5cf7
https://doi.org/10.1016/bs.ctm.2020.01.008
https://doi.org/10.1016/bs.ctm.2020.01.008
Autor:
Thomas Friedel, J. Graham McGeown, Sadaf Ashraf, Jennifer McNaughten, José A Fernández, Patrizia Cincolà, Mary K. McGahon, Alan W. Stitt, Peter Barabas, Tim M. Curtis, Caitriona O'Leary
Publikováno v:
O'Leary, C, McGahon, M K, Ashraf, S, McNaughten, J, Friedel, T, Cincolà, P, Barabas, P, Fernandez, J A, Stitt, A W, McGeown, J G & Curtis, T M 2019, ' Involvement of TRPV1 and TRPV4 Channels in Retinal Angiogenesis ', Investigative ophthalmology & visual science, vol. 60, no. 10, pp. 3297-3309 . https://doi.org/10.1167/iovs.18-26344
Purpose: We investigate the contribution of TRPV1 and TRPV4 channels to retinal angiogenesis.Methods: Primary retinal microvascular endothelial cells (RMECs) were used for RT-PCR, Western blotting, immunolabeling, Ca2+ signaling, and whole-cell patch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0339ec572c00a5cbcee41e73b102350f
https://pure.qub.ac.uk/en/publications/involvement-of-trpv1-and-trpv4-channels-in-retinal-angiogenesis(4181f1fe-619c-4345-84c5-e09748cd9ab6).html
https://pure.qub.ac.uk/en/publications/involvement-of-trpv1-and-trpv4-channels-in-retinal-angiogenesis(4181f1fe-619c-4345-84c5-e09748cd9ab6).html
Autor:
Yasser Abdel-Wahab, Mary K. McGahon, Peter R. Flatt, Opeolu O. Ojo, Tim M. Curtis, Dinesh K. Srinivasan, J. Michael Conlon, Bosede O. Owolabi, R. Charlotte Moffett
Publikováno v:
Biological Chemistry. 397:753-764
The frog skin host-defense peptide tigerinin-1R stimulates insulin releasein vitroand improves glucose tolerance and insulin sensitivity in animal models of type 2 diabetes. This study extends these observations by investigating the molecular mechani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59b0cbd11b4be26197fe8b675f4a0410
https://doi.org/10.1515/hsz-2016-0120
https://doi.org/10.1515/hsz-2016-0120
Autor:
Tim M, Curtis, Declan, McLaughlin, Michael, O'Hare, Joanna, Kur, Peter, Barabas, Gordon, Revolta, C Norman, Scholfield, J Graham, McGeown, Mary K, McGahon
Publikováno v:
Journal of visualized experiments : JoVE. (137)
The retina is a highly metabolically active tissue that requires a substantial blood supply. The retinal circulation supports the inner retina, while the choroidal vessels supply the photoreceptors. Alterations in retinal perfusion contribute to nume
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b3fdfc30947a530de6a62ddd6e573c18
https://pubmed.ncbi.nlm.nih.gov/30059036
https://pubmed.ncbi.nlm.nih.gov/30059036
Autor:
Michael O'Hare, Tim M. Curtis, C. Norman Scholfield, Declan McLaughlin, Gordon Revolta, J. Graham McGeown, Joanna Kur, Peter Barabas, Mary K. McGahon
Publikováno v:
Journal of Visualized Experiments.
The retina is a highly metabolically active tissue that requires a substantial blood supply. The retinal circulation supports the inner retina, while the choroidal vessels supply the photoreceptors. Alterations in retinal perfusion contribute to nume
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0282eec7e81f2d6aa8963869eb35f4ab
https://doi.org/10.3791/57944
https://doi.org/10.3791/57944