Fenretinide inhibits obesity and fatty liver disease but induces Smpd3 to increase serum ceramides and worsen atherosclerosis in LDLR−/− mice

Autor: Dawn Thompson, Shehroz Mahmood, Nicola Morrice, Sarah Kamli-Salino, Ruta Dekeryte, Philip A. Hoffmann, Mary K. Doherty, Philip D. Whitfield, Mirela Delibegović, Nimesh Mody

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)

Abstract Fenretinide is a synthetic retinoid that can prevent obesity and improve insulin sensitivity in mice by directly altering retinol/retinoic acid homeostasis and inhibiting excess ceramide biosynthesis. We determined the effects of Fenretinide

Externí odkaz: https://doaj.org/article/218b2a2f63c145aba6418cd7cdeaf114

Endoplasmic reticulum stress as a key mechanism in stunted growth of seawater rainbow trout (Oncorhynchus mykiss)

Autor: Bernat Morro, Richard Broughton, Pablo Balseiro, Sigurd O. Handeland, Simon Mackenzie, Mary K. Doherty, Phillip D. Whitfield, Munetaka Shimizu, Marnix Gorissen, Harald Sveier, Amaya Albalat

Publikováno v: BMC Genomics, Vol 22, Iss 1, Pp 1-15 (2021)

Abstract Background Rainbow trout (Oncorhynchus mykiss) is a salmonid species with a complex life-history. Wild populations are naturally divided into freshwater residents and sea-run migrants. Migrants undergo an energy-demanding adaptation for life

Externí odkaz: https://doaj.org/article/807b8b16c6d4485cb893338f1b6e2c37

The Mitochondrial PHB Complex Determines Lipid Composition and Interacts With the Endoplasmic Reticulum to Regulate Ageing

Autor: Artur B. Lourenço, María Jesús Rodríguez-Palero, Mary K. Doherty, David Cabrerizo Granados, Blanca Hernando-Rodríguez, Joaquín J. Salas, Mónica Venegas-Calerón, Phillip D. Whitfield, Marta Artal-Sanz

Publikováno v: Frontiers in Physiology, Vol 12 (2021)

Metabolic disorders are frequently associated with physiological changes that occur during ageing. The mitochondrial prohibitin complex (PHB) is an evolutionary conserved context-dependent modulator of longevity, which has been linked to alterations

Externí odkaz: https://doaj.org/article/697df27debee4db39e0559445370b2d1

Plasma proteome profiling of freshwater and seawater life stages of rainbow trout (Oncorhynchus mykiss).

Autor: Bernat Morro, Mary K Doherty, Pablo Balseiro, Sigurd O Handeland, Simon MacKenzie, Harald Sveier, Amaya Albalat

Publikováno v: PLoS ONE, Vol 15, Iss 1, p e0227003 (2020)

The sea-run phenotype of rainbow trout (Oncorhynchus mykiss), like other anadromous salmonids, present a juvenile stage fully adapted to life in freshwater known as parr. Development in freshwater is followed by the smolt stage, where preadaptations

Externí odkaz: https://doaj.org/article/e7225fdb7dca4066b1734cf84955ecf6

CBL/CAP Is Essential for Mitochondria Respiration Complex I Assembly and Bioenergetics Efficiency in Muscle Cells

Autor: Cho-Cho Aye, Dean E. Hammond, Sergio Rodriguez-Cuenca, Mary K. Doherty, Phillip D. Whitfield, Marie M. Phelan, Chenjing Yang, Rafael Perez-Perez, Xiaoxin Li, Angels Diaz-Ramos, Gopal Peddinti, Matej Oresic, Antonio Vidal-Puig, Antonio Zorzano, Cristina Ugalde, Silvia Mora

Publikováno v: International Journal of Molecular Sciences
Volume 24
Issue 4
Pages: 3399
Aye, C C, Hammond, D E, Rodriguez-Cuenca, S, Doherty, M K, Whitfield, P D, Phelan, M M, Yang, C, Perez-Perez, R, Li, X, Diaz-Ramos, A, Peddinti, G, Oresic, M, Vidal-Puig, A, Zorzano, A, Ugalde, C & Mora, S 2023, ' CBL/CAP Is Essential for Mitochondria Respiration Complex I Assembly and Bioenergetics Efficiency in Muscle Cells ', International Journal of Molecular Sciences, vol. 24, no. 4, 3399 . https://doi.org/10.3390/ijms24043399

Peer reviewed: True
Funder: European Regional Development Fund
Funder: Scottish Funding Council
Funder: Highlands and Islands Enterprise
CBL is rapidly phosphorylated upon insulin receptor activation. Mice whole body CBL depletion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::104678bf02f7ae0237dddc96970d23f3
https://www.repository.cam.ac.uk/handle/1810/347194