Výsledky vyhledávání - "Mary Jo Vodicnik"

The influence of time of maternal exposure to 2,4,5,2′,4′,5′-hexachlorobiphenyl on its accumulation in their nursing offspring

Autor: Barbara J. Ring, Mary Jo Vodicnik, Lori A. Gallenberg

Publikováno v: Toxicology and Applied Pharmacology. 104:1-8

2,4,5,2′,4′,5′-Hexachlorobiphenyl (6-CB) is mobilized from rodent tissues during the lipid depletion associated with food restriction or lactation, the latter condition resulting in the substantial elimination of the maternal body burden of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f16df17693b0aa934c0ddcbbb0aed8b4
https://doi.org/10.1016/0041-008x(90)90276-z

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Concomitant toxicokinetics: techniques for and interpretation of exposure data obtained during the conduct of toxicology studies

Autor: Mary Jo Vodicnik, Sandra R. Allerheiligen, Andrew M. Dahlem

Publikováno v: Toxicologic pathology. 23(2)

Toxicokinetic analyses have become a routine component of preclinical toxicology studies with pharmaceutical candidates. Evaluation of plasma and/or tissue samples from animals used in toxicology studies (or concurrent satellite groups) provides info

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aa1c7e2675a248d5f8bbf27f6d7ff8b
https://pubmed.ncbi.nlm.nih.gov/7569672

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Cardiovascular and adrenal proliferative lesions in Fischer 344 rats induced by long-term treatment with type III phosphodiesterase inhibitors (positive inotropic agents), isomazole and indolidan

Autor: Mary Jo Vodicnik, Roy N. Tamura, George E. Sandusky

Publikováno v: Fundamental and applied toxicology : official journal of the Society of Toxicology. 16(1)

Male and female Fischer 344 rats were treated with the positive inotropic agents, isomazole or indolidan, in the diet for 104 weeks. The doses were 0.0, 11.5, 23.5, or 48.0 mg/kg and 0.0, 0.12, 0.40, or 1.3 mg/kg, respectively. Only 17% of the males

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::182123eea0e271afa6bc6e8d21326372
https://pubmed.ncbi.nlm.nih.gov/2019345

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The effect of diet and litter size on the elimination of 2,4,5,2',4',5'-[14C]hexachlorobiphenyl from lactating mice

Autor: Barbara J. Ring, Lori A. Gallenberg, Mary Jo Vodicnik, Karen R. Seitz

Publikováno v: Toxicology and applied pharmacology. 104(1)

It was shown that 2,4,5,2',4',5'-hexachlorobiphenyl (6-CB) administered to adult female mice accumulated in their nursing offspring more rapidly than a dose administered to weanling mice when treated animals were bred at equivalent ages. This suggest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c5023f4d2cd5a148c628ba2fd2a02d2
https://pubmed.ncbi.nlm.nih.gov/2113721

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Influence of lipolysis on the mobilization of 2,4,5,2′4′,5′‐hexachlorobiphenyl from adipocytes in vitro

Autor: Barbara J. Ring, Mary Jo Vodicnik, Lori A. Gallenberg

Publikováno v: Journal of Toxicology and Environmental Health. 20:163-171

Epididymal adipocytes, isolated from rats pretreated with [14C]-2,4,5,2',4',5'-hexachlorobiphenyl (6-CB), were utilized to examine the relationship between the mobilization of lipid and 6-CB and to determine whether 6-CB was differentially associated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bba87b431c458a3d88bea317c625a58
https://doi.org/10.1080/15287398709530969

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Effects of photoperiod-temperature regimes on pituitary gonadotrophs, pituitary gonadotropin potency and hypothalamic gonadotropin releasing acitivity in the teleost notemigonus crysoleucas

Autor: Mary Jo Vodicnik, Victor L. de Vlaming

Publikováno v: Journal of Thermal Biology. 1:119-125

1. 1.|The effects of various photoperiod-temperature regimes on gonadal activity, hypothalamic gonadotropin releasing activity, pituitary gonadotropin potency and pituitary gonadotrophs were examined in the teleost, Notemigonus crysoleucas . 2. 2.|In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b646df8c9e4464c3acc15e29449310bf
https://doi.org/10.1016/0306-4565(76)90031-0

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The effect of pregnancy and lactation on the disposition of 62,4,2?,4?-14C9tetrachlorobiphenyl in the mouse

Autor: Mary Jo Vodicnik

Publikováno v: Fundamental and Applied Toxicology. 6:53-61

The disposition of 150 mg/kg 2,4,2′,4′-tetrachlorobiphenyl (4-CB) administered intraperitoneally as a function of nonpregnant body weight was studied in virgin, late pregnant, and early postpartum mice and their offspring. Highest concentrations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dacc3db686cf9b4cd76c3485a91be7f5
https://doi.org/10.1016/0272-0590(86)90263-0

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