Syndecan 4 is required for endothelial alignment in flow and atheroprotective signaling

Autor: John Rhodes, Martin A. Schwartz, David D. Simon, Cecile O. Mejean, Federico Corti, Tyler D Ross, Thomas Z. Wang, Jay D. Humphrey, Michael Simons, Nicolas Baeyens, Mary Jo Mulligan-Kehoe

Publikováno v: Baeyens, N, Mulligan-Kehoe, M J, Corti, F, Simon, D D, Ross, T D, Rhodes, J M, Wang, T Z, Mejean, C O, Simons, M, Humphrey, J & Schwartz, M A 2014, ' Syndecan 4 is required for endothelial alignment in flow and atheroprotective signaling ', Proceedings of the National Academy of Sciences of the United States of America, vol. 111, no. 48, pp. 17308-13 . https://doi.org/10.1073/pnas.1413725111

Atherosclerotic plaque localization correlates with regions of disturbed flow in which endothelial cells (ECs) align poorly, whereas sustained laminar flow correlates with cell alignment in the direction of flow and resistance to atherosclerosis. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b1dec36bc562c2070fcc3a82ae0b2bf
https://doi.org/10.1073/pnas.1413725111

Fibroblast Growth Factor-2 Is Required for Vasa Vasorum Plexus Stability in Hypercholesterolemic Mice

Autor: Andrew J. Park, Michael Simons, Thomas Z. Wang, Samantha Shipman, Jessica Mollmark, Mary Jo Mulligan-Kehoe, Justin Kim, Lyubomir Zagorchev, Sarah Katzenell

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 32:2644-2651

Objective— Vasa vasorum are angiogenic in advanced stages of human atherosclerosis and hypercholesterolemic mouse models. Fibroblast growth factor-2 (FGF-2) is the predominant angiogenic growth factor in the adventitia and plaque of hypercholestero

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4366453157f508ef009cb19f54a87c8
https://doi.org/10.1161/atvbaha.112.252544

ERK1/2-Akt1 crosstalk regulates arteriogenesis in mice and zebrafish

Autor: Anthony A. Lanahan, Tatiana V. Byzova, Bin Ren, Arpita Mukhopadhyay, Zhen W. Zhuang, Karen L Moodie, Michael Simons, Randall T. Peterson, Mary Jo Mulligan-Kehoe, Yong Deng

Publikováno v: Journal of Clinical Investigation. 120:1217-1228

Arterial morphogenesis is an important and poorly understood process. In particular, the signaling events controlling arterial formation have not been established. We evaluated whether alterations in the balance between ERK1/2 and PI3K signaling path

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dbc2e37a311d889b0914110b28f15ab
https://doi.org/10.1172/jci39837

The Antiangiogenic Activity of rPAI-1 23 Inhibits Vasa Vasorum and Growth of Atherosclerotic Plaque

Autor: Jessica Mollmark, Mary Jo Mulligan-Kehoe, Karen L Moodie, Amy Hall, Mary C. Drinane, Lyubomir Zagorchev, Michael Simons, Baiming Sun, Samantha Shipman, Peter Morganelli

Publikováno v: Circulation Research. 104:337-345

Plaque vascularity has been implicated in its growth and stability. However, there is a paucity of information regarding the origin of plaque vasculature and the role of vasa vasorum in plaque growth. To inhibit growth of vasa vasorum in atherogenic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9089e13dfb9860676cd8a3c248bed767
https://doi.org/10.1161/circresaha.108.184622

Current concepts in normal and defective angiogenesis: Implications for systemic sclerosis

Autor: Michael Simons, Mary Jo Mulligan-Kehoe

Publikováno v: Current Rheumatology Reports. 9:173-179

Vascular abnormalities are a major component of systemic sclerosis, but little is known about the events or mechanisms that initiate vascular injury and prevent its repair. Early stages of systemic sclerosis are characterized by an exaggerated angiog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b141ee3bbcbced389961b9dc63e87f64
https://doi.org/10.1007/s11926-007-0013-2