Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Mary Jo Caranfa"'
Autor:
Jeffrey C. Boehm, Dalia R. Jakas, Robert P. Hertzberg, Sidney M. Hecht, Gregory Gallagher, Randall K. Johnson, William Dennis Kingsbury, Leo F. Faucette, Francis L. McCabe, Mary Jo Caranfa, K. G. Holden
Publikováno v:
Journal of Medicinal Chemistry. 34:98-107
Water-soluble analogues of the antitumor alkaloid camptothecin (1) were prepared in which aminoalkyl groups were introduced into ring A or B. Most of the analogues were prepared by oxidation of camptothecin to 10-hydroxycamptothecin (2) followed by a
Publikováno v:
BioEssays. 1:272-276
The preparation of samples for gene diagnosis is time-consuming, labor-intensive and costly. These problems can be overcome by dissolving a biological source in a strong solution of a chaotropic salt, then filtering the solution through an immobilizi
Publikováno v:
Biochemistry. 27:3164-3174
Bleomycin-mediated DNA strand scission has been shown to be diminished at certain sequences in proximity to 5-methylcytidines. We have investigated the molecular basis of this observed diminution using selective bleomycin (BLM) modifications at the C
Publikováno v:
British Journal of Haematology. 50:521-530
Platelets from 28 patients with the myeloproliferative diseases (MPD) polycythaemia vera (9), essential thrombocythaemia (6), myelofibrosis with myeloid metaplasia (5) and chronic myelogenous leukaemia (8) were examined for an RNA-dependent DNA polym
Autor:
Robert P. Hertzberg, Randall K. Johnson, J O Bartus, Shau Ming Mong, Michael R. Mattern, Dalia R. Jakas, Gregory Gallagher, Kenneth G. Holden, Mary Jo Caranfa, William D. Kingsbury
Publikováno v:
Journal of medicinal chemistry. 32(3)
Several camptothecin derivatives containing a modified hydroxy lactone ring have been synthesized and evaluated for inhibition of topoisomerase I and cytotoxicity to mammalian cells. Each of the groups of the hydroxy lactone moiety, the carbonyl oxyg
Publikováno v:
Biochemistry. 24(20)
Three DNA duplexes differing substantially in sequence were derived from pBR322 plasmid DNA and supercoiled SV40 DNA by digestion with appropriate restriction endonucleases. Following treatment with the restriction methylase HhaI (recognition sequenc
Publikováno v:
Biochemistry. 28(11)
Camptothecin, a cytotoxic antitumor compound, has been shown to produce protein-linked DNA breaks mediated by mammalian topoisomerase I. We have investigated the mechanism by which camptothecin disrupts DNA processing by topoisomerase I and have exam