Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Mary Jane Masson Hinrichs"'
Autor:
Patrick H. van Berkel, Ronald Herbst, David A. Tice, Steve Coats, John A. Hartley, Philip W. Howard, Neil H. Bander, Sae Kim, He Liu, Eva Corey, Simon Chivers, Mary Jane Masson Hinrichs, Martin Korade, Patrick Strout, Kevin Schifferli, Ravinder Tammali, Karma Dacosta, Wanda King, Charles E. Britten, Sandamali Dissanayake, Halla W. Reinert, Lauren Adams, Simon Corbett, Francois Bertelli, Nazzareno Dimasi, Kapil Vashisht, Ryan Fleming, Francois D'Hooge, Peter Tyrer, Noel R. Monks, Carin E.G. Havenith, David G. Williams, Francesca Zammarchi, Song Cho
Supplementary Figure S1. Retention of MEDI3726 activity in human, cynomolgus monkey plasma or PBS for up to 7 days. Supplementary Figure S2. Kaplan-Meier analysis of the Time-to-Endpoint Survival in the (A) LNCaP, (B) CWR22Rv1, and (C) PC-3 Xenograft
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fba3333e7f01b57533060b9dc76a71f
https://doi.org/10.1158/1535-7163.22505436.v1
https://doi.org/10.1158/1535-7163.22505436.v1
Autor:
Patrick H. van Berkel, Ronald Herbst, David A. Tice, Steve Coats, John A. Hartley, Philip W. Howard, Neil H. Bander, Sae Kim, He Liu, Eva Corey, Simon Chivers, Mary Jane Masson Hinrichs, Martin Korade, Patrick Strout, Kevin Schifferli, Ravinder Tammali, Karma Dacosta, Wanda King, Charles E. Britten, Sandamali Dissanayake, Halla W. Reinert, Lauren Adams, Simon Corbett, Francois Bertelli, Nazzareno Dimasi, Kapil Vashisht, Ryan Fleming, Francois D'Hooge, Peter Tyrer, Noel R. Monks, Carin E.G. Havenith, David G. Williams, Francesca Zammarchi, Song Cho
Table S1. P values of comparing time to endpoint survival among all treatment groups in the LNCaP xenograft study Table S2. Summary of PSMA IHC in xenograft tumors Table S3. P values of comparing time to endpoint survival among all treatment groups i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::231399c1a6b9388e7ff58e433d77c143
https://doi.org/10.1158/1535-7163.22505430
https://doi.org/10.1158/1535-7163.22505430
Autor:
Patrick H. van Berkel, Ronald Herbst, David A. Tice, Steve Coats, John A. Hartley, Philip W. Howard, Neil H. Bander, Sae Kim, He Liu, Eva Corey, Simon Chivers, Mary Jane Masson Hinrichs, Martin Korade, Patrick Strout, Kevin Schifferli, Ravinder Tammali, Karma Dacosta, Wanda King, Charles E. Britten, Sandamali Dissanayake, Halla W. Reinert, Lauren Adams, Simon Corbett, Francois Bertelli, Nazzareno Dimasi, Kapil Vashisht, Ryan Fleming, Francois D'Hooge, Peter Tyrer, Noel R. Monks, Carin E.G. Havenith, David G. Williams, Francesca Zammarchi, Song Cho
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c4924695dc910a4941d12258d7652e0
https://doi.org/10.1158/1535-7163.22505433.v1
https://doi.org/10.1158/1535-7163.22505433.v1
Autor:
Patrick H. van Berkel, Ronald Herbst, David A. Tice, Steve Coats, John A. Hartley, Philip W. Howard, Neil H. Bander, Sae Kim, He Liu, Eva Corey, Simon Chivers, Mary Jane Masson Hinrichs, Martin Korade, Patrick Strout, Kevin Schifferli, Ravinder Tammali, Karma Dacosta, Wanda King, Charles E. Britten, Sandamali Dissanayake, Halla W. Reinert, Lauren Adams, Simon Corbett, Francois Bertelli, Nazzareno Dimasi, Kapil Vashisht, Ryan Fleming, Francois D'Hooge, Peter Tyrer, Noel R. Monks, Carin E.G. Havenith, David G. Williams, Francesca Zammarchi, Song Cho
Prostate-specific membrane antigen (PSMA) is a membrane-bound glutamate carboxypeptidase that is highly expressed in nearly all prostate cancers with the highest expression in metastatic castration-resistant prostate cancer (mCRPC). The prevalence of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::321b0f7676a6116fbc4184f047275750
https://doi.org/10.1158/1535-7163.c.6538059.v1
https://doi.org/10.1158/1535-7163.c.6538059.v1
Autor:
Rakesh Dixit, Nazzareno Dimasi, Phillip W. Howard, Arnaud Tiberghien, Luke Masterson, Cui Chen, Neki Patel, Shannon Breen, Patricia C. Ryan, Molly Reed, Marlon Rebelatto, Kapil Vashisht, Binyam Bezabeh, Jay Harper, Haihong Zhong, Michele Gunsior, Xiang Qing Yu, Shameen Afif-Rider, Bo Zheng, Pauline M. Ryan, Mary Jane Masson Hinrichs
Purpose: To use preclinical models to identify a dosing schedule that improves tolerability of highly potent pyrrolobenzodiazepine dimers (PBDs) antibody drug conjugates (ADCs) without compromising antitumor activity.Experimental Design: A series of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09bff01a2c0da935c0ea2819fe0a9ef9
https://doi.org/10.1158/1078-0432.c.6526344
https://doi.org/10.1158/1078-0432.c.6526344
Autor:
Rakesh Dixit, Nazzareno Dimasi, Phillip W. Howard, Arnaud Tiberghien, Luke Masterson, Cui Chen, Neki Patel, Shannon Breen, Patricia C. Ryan, Molly Reed, Marlon Rebelatto, Kapil Vashisht, Binyam Bezabeh, Jay Harper, Haihong Zhong, Michele Gunsior, Xiang Qing Yu, Shameen Afif-Rider, Bo Zheng, Pauline M. Ryan, Mary Jane Masson Hinrichs
Supplementary Figure 1. (a,b) Structure of the payloads SG3249 and SG3400; Supplementary Figure 2. PK concentration vs. time profile of R347-SG3400 in monkeys after either a single IV injection of 4.5mg/kg or 3 weekly IV injections of 1.5mg/kg; Suppl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18262bd2056388988e5e07e301278edb
https://doi.org/10.1158/1078-0432.22466538
https://doi.org/10.1158/1078-0432.22466538
Autor:
Gang Wu, Leiming Xia, Tao Zhang, Lu Wen, Alfred E. Chang, Frank Comer, Max S. Wicha, Yuanyuan Liu, Qiao Li, Mary Jane Hinrichs, Steven Coats, Michael Oberst, Yangyi Bao
Publikováno v:
Cancer Research. 79:4981-4981
HER2-targeted antibody drug conjugate (ADC) was only tested in immunocompromised (SCID) host, which doesn’t allow the evaluation of the ADC-induced host immune responses. In addition, no potential impact of ADC on cancer stem cells (CSCs) has been
Autor:
Noel R. Monks, Francesca Zammarchi, Wanda King, Ryan Fleming, Simon Chivers, David A. Tice, Ronald Herbst, Patrick Van Berkel, Kevin Schifferli, Mary Jane Hinrichs, Nazzareno Dimasi, Steve Coats, David G. Williams, Ravinder Tammali, Kapil Vashisht, Karma Dacosta, Phil W. Howard, Karin Havenith, Song Cho, Patrick Strout, John A. Hartley
Publikováno v:
Cancer Research. 78:A004-A004
Prostate specific membrane antigen (PSMA), a type II membrane glycoprotein, is highly expressed in nearly all prostate cancers, with the highest expression in metastatic castration-resistant prostate cancer (mCRPC). The prevalence, increased surface
Autor:
Marlon Rebelatto, Leslie Wetzel, John Li, Brandon Lam, Samuel R. Perry, Jane K. Osbourn, Pamela Thompson, Dorin Toader, Changshou Gao, Ryan Fleming, Steven Coats, Xian-Qing Yu, Rakesh Dixit, Herren Wu, Vanessa Muniz-Medina, Nazzareno Dimasi, Mary Jane Hinrichs, Binyam Bezabeh
Publikováno v:
Cancer Research. 76:2970-2970
Antibody drug conjugates (ADCs) combine the specificity of antibodies with the potent cytotoxicity of small molecule drugs and have shown to provide therapeutic options for various cancers. We report herein the discovery of a HER2-targeting ADC MEDI4