Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Mary Jane Hinrichs"'
Autor:
Adeela Kamal, Ronald Herbst, Robert E. Hollingsworth, David A. Tice, Philip W. Howard, Keven Huang, Mary Jane Hinrichs, Elaine M. Hurt, Haihong Zhong, Marlon Rebelatto, Sanjoo Jalla, Lilian van Vlerken-Ysla, Shannon Breen, Leslie Wetzel, Cui Chen, Linda Xu, Patrick Strout, Martin Korade, Allison M. Marrero, Shenlan Mao, Francois D'Hooge, Ryan Fleming, Jelena Jovanovic, David Bannister, Leeanne Lewis, Rose Marwood, Dorin Toader, Nazzareno Dimasi, Christopher Lloyd, Jay Harper
Supplementary Figure S1. Comparable internalization rates for 5T4_0108 and the 5T4-Tub ADC;Supplementary Figure S2. Affinity optimization improves in vitro cytotoxicity of a 5T4-ADC;Supplementary Figure S3. Induction of apoptosis by 5T4-PBD and 5T4-T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de526dbdf0be492e85149344521acac5
https://doi.org/10.1158/1535-7163.22508511
https://doi.org/10.1158/1535-7163.22508511
Autor:
Daniel P. Petrylak, Pablo Martinez, Song Cho, Kapil Vashisht, Meina Liang, Anton I. Rosenbaum, Marna Williams, Peng He, Qu Zhang, Mary Jane Hinrichs, John Bothos, Manuel Selvi Miralles, Richard Cathomas, Judy S. Wang, Mark T. Fleming, Johann S. de Bono
Per-patient ADA responses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8ed549e5806b16ebd18f122d134b36f
https://doi.org/10.1158/1078-0432.22481330
https://doi.org/10.1158/1078-0432.22481330
Autor:
Daniel P. Petrylak, Pablo Martinez, Song Cho, Kapil Vashisht, Meina Liang, Anton I. Rosenbaum, Marna Williams, Peng He, Qu Zhang, Mary Jane Hinrichs, John Bothos, Manuel Selvi Miralles, Richard Cathomas, Judy S. Wang, Mark T. Fleming, Johann S. de Bono
Summary of mean (%CV) PK parameters of Total ADC and Active ADC after a single IV infusion of MEDI3726
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c7724c99edd8d3a0ee5b1984cf8685d
https://doi.org/10.1158/1078-0432.22481336
https://doi.org/10.1158/1078-0432.22481336
Autor:
Daniel P. Petrylak, Pablo Martinez, Song Cho, Kapil Vashisht, Meina Liang, Anton I. Rosenbaum, Marna Williams, Peng He, Qu Zhang, Mary Jane Hinrichs, John Bothos, Manuel Selvi Miralles, Richard Cathomas, Judy S. Wang, Mark T. Fleming, Johann S. de Bono
CTC while on treatment (patients with at least one CTC measurement >50)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1327fb0781f338470585d55ccfdf376c
https://doi.org/10.1158/1078-0432.22481345.v1
https://doi.org/10.1158/1078-0432.22481345.v1
Autor:
Daniel P. Petrylak, Pablo Martinez, Song Cho, Kapil Vashisht, Meina Liang, Anton I. Rosenbaum, Marna Williams, Peng He, Qu Zhang, Mary Jane Hinrichs, John Bothos, Manuel Selvi Miralles, Richard Cathomas, Judy S. Wang, Mark T. Fleming, Johann S. de Bono
Mutation profiles in ctDNA: truncating and/or pathogenic mutations in DDR or DDR-related pathway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae47a30e84d5fba46594879d91fa09cd
https://doi.org/10.1158/1078-0432.22481342
https://doi.org/10.1158/1078-0432.22481342
Autor:
Daniel P. Petrylak, Pablo Martinez, Song Cho, Kapil Vashisht, Meina Liang, Anton I. Rosenbaum, Marna Williams, Peng He, Qu Zhang, Mary Jane Hinrichs, John Bothos, Manuel Selvi Miralles, Richard Cathomas, Judy S. Wang, Mark T. Fleming, Johann S. de Bono
Purpose:MEDI3726 is an antibody–drug conjugate targeting the prostate-specific membrane antigen and carrying a pyrrolobenzodiazepine warhead. This phase I study evaluated MEDI3726 monotherapy in patients with metastatic castration-resistant prostat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dcb56fd85cee8a652c6debce500acf0
https://doi.org/10.1158/1078-0432.c.6530666.v1
https://doi.org/10.1158/1078-0432.c.6530666.v1
Autor:
Alison Scott, Alan N. Hunt, Dominic J. Corkill, Nicholas J. White, Patricia C. Ryan, Anthony D. Postle, Lorin Roskos, Marlon Rebelatto, Mary Jane Hinrichs, Matthew J Robinson, Josquin A Nys, Matthew Sleeman
Granulocyte macrophage colony stimulating factor (GM-CSF) is a key participant in, and a clinical target for, the treatment of inflammatory diseases including rheumatoid arthritis (RA). Therapeutic inhibition of GM-CSF signalling using monoclonal ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f387d3995ba16db8e7128ba41dea8042
https://eprints.soton.ac.uk/452362/
https://eprints.soton.ac.uk/452362/
Autor:
Luke Masterson, Jason White, Mary Jane Hinrichs, Ryan Fleming, Kim Rosenthal, Rakesh Dixit, Herren Wu, Changshou Gao, Christine Fazenbaker, Vanessa Muniz-Medina, Ben T Ruddle, Philip Howard, Haihong Zhong, Nazzareno Dimasi, Molly Reed, Patrick Strout
Publikováno v:
mAbs. 11:500-515
Most strategies used to prepare homogeneous site-specific antibody-drug conjugates (ADCs) result in ADCs with a drug-to-antibody ratio (DAR) of two. Here, we report a disulfide re-bridging strategy to prepare homogeneous ADCs with DAR of one using a
Autor:
Sean Turman, Benjamin Kemp, Ronald Herbst, Janet Griffiths, Jennifer Cann, Mary Jane Hinrichs, M. Jack Borrok, Lisa Marie Kitching Vinall, D. Gareth Rees, David Howe, Yue Wang, Carlos Gonzalez, Shu Wang, Steven Eck, Hong Sun, Brian Naiman, Katherine A. Vousden, Koshu Okubo, Roland Kolbeck, Antonio DiGiandomenico, Tanya N. Mayadas, Gary P. Sims, Ethan Grant, Neang Ly, Ximing Xiong, Yebin Zhou, Srinath Kasturiangan, Holly Koelkebeck, Weiguang Zhao, Christopher Morehouse, Bo Chen
Publikováno v:
Annals of the Rheumatic Diseases
ObjectiveImmune complexes (ICs) play a critical role in the pathology of autoimmune diseases. The aim of this study was to generate and characterise a first-in-class anti-FcγRIIA antibody (Ab) VIB9600 (previously known as MEDI9600) that blocks IgG i
Autor:
Judy S. Wang, Manuel Selvi Miralles, Daniel P. Petrylak, Peng He, John G. Bothos, Kapil Vashisht, Marna Williams, Qu Zhang, Mark D. Fleming, Mary Jane Hinrichs, Pablo Martinez, Anton I. Rosenbaum, Johann S. de Bono, Song Cho, Richard Cathomas, Meina Liang
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 27(13)
Purpose: MEDI3726 is an antibody–drug conjugate targeting the prostate-specific membrane antigen and carrying a pyrrolobenzodiazepine warhead. This phase I study evaluated MEDI3726 monotherapy in patients with metastatic castration-resistant prosta