1160 Phosphonate-antibody-drug conjugates: a novel immunostimulatory class of ADCs driving inside-out activation of Vγ9Vδ2 T cells leading to selective tumor cell killing

Autor: Lilian Driessen-Engels, Roel J Arends, Désirée Damming, Wendela A Kappers, Gijs Verheijden, Mary J van Helden, Ronald C Elgersma, Daphne WJ van Kuppeveld, Dennis Waalboer, Ellen WH Santegoeds-Lenssen, Inge Leenders, Karin de Laat-Arts, Marc CBC Paradé, Menno Winkel, Anja Scholzen, Daniëlle EJW van Wijk, Diels van den Dobbelsteen, Genny Filiciotto, Laura Assink, Myrthe Rouwette, Panagiota I Spantidea, Timo K van den Berg, Wim HA Dokter, Miranda MC van der Lee

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Externí odkaz: https://doaj.org/article/0bdf2e0ad85f4e3c8e9e2cbae21d91f1

BYON4228 is a pan-allelic antagonistic SIRPα antibody that potentiates destruction of antibody-opsonized tumor cells and lacks binding to SIRPγon T cells

Autor: Mary J van Helden, Seline A Zwarthoff, Roel J Arends, Inge M J Reinieren-Beeren, Marc C B C Paradé, Lilian Driessen-Engels, Karin de Laat-Arts, Désirée Damming, Ellen W H Santegoeds-Lenssen, Daphne W J van Kuppeveld, Imke Lodewijks, Hugo Olsman, Hanke L Matlung, Katka Franke, Ellen Mattaar-Hepp, Marloes E M Stokman, Benny de Wit, Dirk H R F Glaudemans, Daniëlle E J W van Wijk, Lonnie Joosten-Stoffels, Jan Schouten, Paul J Boersema, Monique van der Vleuten, Jorien W H Sanderink, Wendela A Kappers, Diels van den Dobbelsteen, Marco Timmers, Ruud Ubink, Gerard J A Rouwendal, Gijs Verheijden, Miranda M C van der Lee, Wim H A Dokter, Timo K van den Berg

Publikováno v: van Helden, M J, Zwarthoff, S A, Arends, R J, Reinieren-Beeren, I M J, Paradé, M C B C, Driessen-Engels, L, de Laat-Arts, K, Damming, D S, Santegoeds-Lenssen, E W H, van Kuppeveld, D W J, Lodewijks, I, Olsman, H, Matlung, H L, Franke, K, Mattaar-Hepp, E, Stokman, M E M, de Wit, B, Glaudemans, D H R F, van Wijk, D E J W, Joosten-Stoffels, L, Schouten, J, Boersema, P J, van der Vleuten, M, Sanderink, J W H, Kappers, W A, van den Dobbelsteen, D, Timmers, M, Ubink, R, Rouwendal, G J A, Verheijden, G, van der Lee, M M C, Dokter, W H A & van den Berg, T K 2023, ' BYON4228 is a pan-allelic antagonistic SIRPα antibody that potentiates destruction of antibody-opsonized tumor cells and lacks binding to SIRPγon T cells ', Journal for Immunotherapy of Cancer, vol. 11, no. 4, jitc-2022-006567 . https://doi.org/10.1136/jitc-2022-006567

BackgroundPreclinical studies have firmly established the CD47-signal-regulatory protein (SIRP)α axis as a myeloid immune checkpoint in cancer, and this is corroborated by available evidence from the first clinical studies with CD47 blockers. Howeve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12f6e6308ed606888d418126a12792c8
https://research.vumc.nl/en/publications/67116c0e-064c-4154-86d3-6797beec296d

Mouse Models of Asthma

Autor: Bart N. Lambrecht, Nincy Debeuf, Mary J. van Helden, Eline Haspeslagh, Hamida Hammad

Publikováno v: Current Protocols in Mouse Biology

Allergic asthma is a chronic inflammatory disease of the conducting airways characterized by the presence of allergen-specific IgE, Th2 cytokine production, eosinophilic airway inflammation, bronchial hyperreactivity, mucus overproduction, and struct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1baf0a1edd9c23ae155dabcfb4d95749
https://doi.org/10.1002/cpmo.4

Epitope mapping and kinetics of CD4 T cell immunity to pneumonia virus of mice in the C57BL/6 strain

Autor: Mary J. van Helden, Andrew J. Easton, Sophie Janssens, Bart N. Lambrecht, Lana Vandersarren, James J. Moon, Cedric Bosteels, Gert Van Isterdael, Manon Vanheerswynghels

Publikováno v: SCIENTIFIC REPORTS
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Scientific Reports

Pneumonia virus of mice (PVM) infection has been widely used as a rodent model to study the closely related human respiratory syncytial virus (hRSV). While T cells are indispensable for viral clearance, they also contribute to immunopathology. To gai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5827df3fa427f721f5389b20270fef77
https://doi.org/10.1038/s41598-017-03042-y

Dendritic Cells and Type 2 Inflammation

Autor: Hamida Hammad, Mary J. van Helden, Bart N. Lambrecht

Publikováno v: The Th2 Type Immune Response in Health and Disease ISBN: 9781493929108

CD4 Th2 lymfocytes producing IL-4, IL-5 and IL-13 are common controllers of type 2 immunity. They respond to allergens and helminthes only when antigen is presented by professional antigen presenting cells like dendritic cells. Dendritic cells expres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c0ae18cdb0498956aafa1d4398e64103
https://doi.org/10.1007/978-1-4939-2911-5_3