Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Mary J. Morrison"'
Publikováno v:
Cancer Genetics and Cytogenetics. 113:126-133
A case of acute myeloid leukemia (M2) with double minute chromosomes and complex karyotypic abnormalities was analyzed cytogenetically and molecularly. Comparative genomic hybridization (CGH) showed that the 8q24 region that contains the MYC oncogene
Publikováno v:
Cancer Genetics and Cytogenetics. 112:144-148
We have characterized the double minute chromosomes in a case of acute myeloid leukemia (AML). Southern blot analysis showed that the C-MYC was amplified. Further analysis with probes located both 3' and 5' of MYC indicated that the amplicon was at l
Autor:
Mary J. Morrison, Peter E. Crossen
Publikováno v:
Mechanisms of Ageing and Development. 88:61-65
We studied the frequency of an Sst I polymorphism of the ETS-I oncogene in 122 elderly subjects (mean age 78.14 years) and 115 teenagers (mean age 16.9 years). No difference in the frequency of the three genotypes (C1C1, C1C2, C2C2) was found between
Autor:
Peter E. Crossen, Mary J. Morrison
Publikováno v:
Leukemia Research. 23:251-253
We examined the methylation status of the third exon of the MYC oncogene in 39 patients with B-cell malignancies. DNA was digested with MspI plus EcoRI or HpaII plus EcoRI and hybridised with a probe specific for the third exon of MYC. Thirty four pa
Autor:
Gabi U. Dachs, Sarah P. Gunningham, Mary J. Morrison, Margaret J. Currie, Margret C. M. Vissers
Publikováno v:
Free radical biologymedicine. 42(6)
Control of the transcription factor hypoxia inducible factor (HIF)-1 is mediated by hydroxylation by proline and asparagine hydroxylases. These enzymes require ascorbate for optimal activity, but little attention has been given to the effect of ascor
Publikováno v:
Genes, Chromosomes and Cancer. 8:60-62
The t(14;19) is a recurring translocation found in a small number of cases of chronic B-cell leukemia (CLL). We have cloned and sequenced the breakpoint in a patient with a t(14;19) and shown that the breakpoint on chromosome 14 occurred in the Cμ s
Publikováno v:
Cancer genetics and cytogenetics. 128(2)
Cytogenetic analysis of a patient with non-Hodgkin lymphoma revealed the following karyotype: 49,XXX,t(2;14)(q21;q32),+4,+8,del(13)(q14q21). Southern blot analysis with an Ig region probe showed non-productive rearrangements indicative of a transloca
Autor:
Peter E. Crossen, Mary J. Morrison
Publikováno v:
Leukemialymphoma. 31(5-6)
Analysis of the organisation of the Cmu-switch region of the immunoglobulin heavy chain locus in B-lymphocytes from 80 patients with chronic B-cell leukemia revealed 25 patients with abnormal rearrangements that could not be explained by the normal r
Publikováno v:
Cancer genetics and cytogenetics. 79(1)
We studied the frequency of a SstI polymorphism of the Ets-1 oncogene in 100 patients with non-Hodgkin's lymphoma, 44 patients with Hodgkin's disease, 49 patients with chronic myeloid leukemia, and 100 controls. There was no difference in the genotyp
Publikováno v:
Human Genetics. 93
New HindIII, RsaI and TaqI restriction fragment length polymorphisms (RFLPs) within the haemopoietic cell kinase gene in chromosome band 20q11.2 are described. These RFLPs provide a useful marker for linkage analysis in proximal 20q.