Zobrazeno 1 - 10
of 137
pro vyhledávání: '"Mary J. Meegan"'
Autor:
James P. McKeown, Andrew J. Byrne, Sandra A. Bright, Clara E. Charleton, Shubhangi Kandwal, Ivan Čmelo, Brendan Twamley, Anthony M. McElligott, Darren Fayne, Niamh M. O’Boyle, D. Clive Williams, Mary J. Meegan
Publikováno v:
Pharmaceuticals, Vol 17, Iss 8, p 1034 (2024)
Chronic lymphocytic leukemia (CLL) is a malignancy of mature B cells, and it is the most frequent form of leukemia diagnosed in Western countries. It is characterized by the proliferation and accumulation of neoplastic B lymphocytes in the blood, lym
Externí odkaz:
https://doaj.org/article/ec8f4b69512c421787aea349de4351eb
Autor:
Andrew J. Byrne, Sandra A. Bright, James. P. McKeown, Adam Bergin, Brendan Twamley, Anthony M. McElligott, Sara Noorani, Shubhangi Kandwal, Darren Fayne, Niamh M. O’Boyle, D. Clive Williams, Mary J. Meegan
Publikováno v:
Molecules, Vol 28, Iss 24, p 8095 (2023)
Chronic lymphocytic leukaemia (CLL) is a malignancy of the immune B lymphocyte cells and is the most common leukaemia diagnosed in developed countries. In this paper, we report the synthesis and antiproliferative effects of a series of (E)-9-(2-nitro
Externí odkaz:
https://doaj.org/article/4eb2cf5d956c4622b0b26f06f0efdc53
Autor:
Shu Wang, Azizah M. Malebari, Thomas F. Greene, Shubhangi Kandwal, Darren Fayne, Seema M. Nathwani, Daniela M. Zisterer, Brendan Twamley, Niamh M. O’Boyle, Mary J. Meegan
Publikováno v:
Pharmaceuticals, Vol 16, Iss 7, p 1000 (2023)
A series of novel 3-(prop-1-en-2-yl)azetidin-2-one, 3-allylazetidin-2-one and 3-(buta-1,3-dien-1-yl)azetidin-2-one analogues of combretastatin A-4 (CA-4) were designed and synthesised as colchicine-binding site inhibitors (CBSI) in which the ethylene
Externí odkaz:
https://doaj.org/article/a88c634232124ff8893931a453eafe31
Autor:
Niamh M. O’Boyle, Jean-Jacques Helesbeux, Mary J. Meegan, Astrid Sasse, Elizabeth O’Shaughnessy, Alina Qaisar, Aoife Clancy, Florence McCarthy, Pascal Marchand
Publikováno v:
Pharmaceuticals, Vol 16, Iss 3, p 432 (2023)
The Group for the Promotion of Pharmaceutical Chemistry in Academia (GP2A) held their 30th annual conference in August 2022 in Trinity College Dublin, Ireland. There were 9 keynote presentations, 10 early career researcher presentations and 41 poster
Externí odkaz:
https://doaj.org/article/2ee297a77f5e499aa47fe752cf8860d2
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 76, Iss 8, Pp 1187-1194 (2020)
A series of related substituted 1-(3,4,5-trimethoxyphenyl)azetidin-2-ones have been characterized: 3-(4-fluorophenyl)-4-(4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)azetidin-2-one, C25H24FNO5 (1), 3-(furan-2-yl)-4-(4-methoxyphenyl)-1-(3,4,5-trimethoxy
Externí odkaz:
https://doaj.org/article/2bae3bc2b3bc400abee1abbb0cf21ac1
Publikováno v:
Medical Sciences Forum, Vol 14, Iss 1, p 72 (2022)
Microtubule-targeted drugs are essential chemotherapeutic agents for various types of cancer. We have previously reported the synthesis of 3-vinyl-β-lactams (2-azetidinones) with potent antiproliferative activity against breast cancer MCF-7 cells. A
Externí odkaz:
https://doaj.org/article/0ad0b70152074ef09bc224b36857abb5
Autor:
Azizah M. Malebari, Gabriela Duffy Morales, Brendan Twamley, Darren Fayne, Mohemmed Faraz Khan, Eavan C. McLoughlin, Niamh M. O’Boyle, Daniela M. Zisterer, Mary J. Meegan
Publikováno v:
Pharmaceuticals, Vol 15, Iss 9, p 1044 (2022)
The stilbene combretastatin A-4 (CA-4) is a potent microtubule-disrupting agent interacting at the colchicine-binding site of tubulin. In the present work, the synthesis, characterisation and mechanism of action of a series of 3-fluoro and 3,3-difluo
Externí odkaz:
https://doaj.org/article/ce1244d0e8b94117b595145343d4558c
Autor:
Mary J. Meegan, Niamh M. O’Boyle
Publikováno v:
Pharmaceuticals, Vol 15, Iss 4, p 479 (2022)
This Special Issue of Pharmaceuticals is devoted to significant advances achieved in the field of Anticancer Drugs in 2021 [...]
Externí odkaz:
https://doaj.org/article/00e6ee57641b4a2fa6251f1c9c801f73
Autor:
Azizah M. Malebari, Shu Wang, Thomas F. Greene, Niamh M. O’Boyle, Darren Fayne, Mohemmed Faraz Khan, Seema M. Nathwani, Brendan Twamley, Thomas McCabe, Daniela M. Zisterer, Mary J. Meegan
Publikováno v:
Pharmaceuticals, Vol 14, Iss 11, p 1119 (2021)
Antimitotic drugs that target tubulin are among the most widely used chemotherapeutic agents; however, the development of multidrug resistance has limited their clinical activity. We report the synthesis and biological properties of a series of novel
Externí odkaz:
https://doaj.org/article/7f2b0031e7fb41bc8378c9286946a121
Autor:
Gloria Ana, Patrick M. Kelly, Azizah M. Malebari, Sara Noorani, Seema M. Nathwani, Brendan Twamley, Darren Fayne, Niamh M. O’Boyle, Daniela M. Zisterer, Elisangela Flavia Pimentel, Denise Coutinho Endringer, Mary J. Meegan
Publikováno v:
Pharmaceuticals, Vol 14, Iss 2, p 169 (2021)
We report the synthesis and biochemical evaluation of compounds that are designed as hybrids of the microtubule targeting benzophenone phenstatin and the aromatase inhibitor letrozole. A preliminary screening in estrogen receptor (ER)-positive MCF-7
Externí odkaz:
https://doaj.org/article/c41b78584775460886dc442b2b85cb34