Výsledky vyhledávání - "Mary J Emond"

Akademický článek

Whole genome sequencing of extreme phenotypes identifies variants in CD101 and UBE2V1 associated with increased risk of sexually acquired HIV-1.

Autor: Romel D Mackelprang, Michael J Bamshad, Jessica X Chong, Xuanlin Hou, Kati J Buckingham, Kathryn Shively, Guy deBruyn, Nelly R Mugo, James I Mullins, M Juliana McElrath, Jared M Baeten, Connie Celum, Mary J Emond, Jairam R Lingappa, Partners in Prevention HSV/HIV Transmission Study and the Partners PrEP Study Teams

Publikováno v: PLoS Pathogens, Vol 13, Iss 11, p e1006703 (2017)

Host genetic variation modifying HIV-1 acquisition risk can inform development of HIV-1 prevention strategies. However, associations between rare or intermediate-frequency variants and HIV-1 acquisition are not well studied. We tested for the associa

Externí odkaz: https://doaj.org/article/9cf3ce40b8ed44d4a49ffeaf7035ff55

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Akademický článek

Exome Sequencing of Phenotypic Extremes Identifies CAV2 and TMC6 as Interacting Modifiers of Chronic Pseudomonas aeruginosa Infection in Cystic Fibrosis.

Autor: Mary J Emond, Tin Louie, Julia Emerson, Jessica X Chong, Rasika A Mathias, Michael R Knowles, Mark J Rieder, Holly K Tabor, Debbie A Nickerson, Kathleen C Barnes, NHLBI GO Exome Sequencing Project, Lung Go, Ronald L Gibson, Michael J Bamshad

Publikováno v: PLoS Genetics, Vol 11, Iss 6, p e1005273 (2015)

Discovery of rare or low frequency variants in exome or genome data that are associated with complex traits often will require use of very large sample sizes to achieve adequate statistical power. For a fixed sample size, sequencing of individuals sa

Externí odkaz: https://doaj.org/article/226e711ac59b41c2b39359691ca58cd7

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Akademický článek

Survey of innate immune responses to Burkholderia pseudomallei in human blood identifies a central role for lipopolysaccharide.

Autor: Narisara Chantratita, Sarunporn Tandhavanant, Nicolle D Myers, Sudeshna Seal, Arkhom Arayawichanont, Aroonsri Kliangsa-Ad, Lauren E Hittle, Robert K Ernst, Mary J Emond, Mark M Wurfel, Nicholas P J Day, Sharon J Peacock, T Eoin West

Publikováno v: PLoS ONE, Vol 8, Iss 11, p e81617 (2013)

B. pseudomallei is a gram-negative bacterium that causes the tropical infection melioidosis. In northeast Thailand, mortality from melioidosis approaches 40%. As exemplified by the lipopolysaccharide-Toll-like receptor 4 interaction, innate immune re

Externí odkaz: https://doaj.org/article/29253def4ff94851b3bb71976de2a6d3

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Akademický článek

Host genetic risk factors for West Nile virus infection and disease progression.

Autor: Abigail W Bigham, Kati J Buckingham, Sofia Husain, Mary J Emond, Kathryn M Bofferding, Heidi Gildersleeve, Ann Rutherford, Natalia M Astakhova, Andrey A Perelygin, Michael P Busch, Kristy O Murray, James J Sejvar, Sharone Green, John Kriesel, Margo A Brinton, Michael Bamshad

Publikováno v: PLoS ONE, Vol 6, Iss 9, p e24745 (2011)

West Nile virus (WNV), a category B pathogen endemic in parts of Africa, Asia and Europe, emerged in North America in 1999, and spread rapidly across the continental U.S. Outcomes of infection with WNV range from asymptomatic to severe neuroinvasive

Externí odkaz: https://doaj.org/article/3571f5782dba4ae1ba65a4328ef71a4e

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Akademický článek

Disruption of protein kinase A in mice enhances healthy aging.

Autor: Linda C Enns, John F Morton, Piper R Treuting, Mary J Emond, Norman S Wolf, Dao-Fu Dai, G S McKnight, Peter S Rabinovitch, Warren C Ladiges

Publikováno v: PLoS ONE, Vol 4, Iss 6, p e5963 (2009)

Mutations that cause a reduction in protein kinase A (PKA) activity have been shown to extend lifespan in yeast. Loss of function of mammalian RIIbeta, a regulatory subunit of PKA expressed in brain and adipose tissue, results in mice that are lean a

Externí odkaz: https://doaj.org/article/f5f89b0c352a4d5982cb83d6dc30728e

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Club cell secretory protein and lung function in children with cystic fibrosis

Autor: Jing Zhai, Mary J. Emond, Amber Spangenberg, Debra A. Stern, Monica M. Vasquez, Elizabeth E. Blue, Kati J. Buckingham, Duane L. Sherrill, Marilyn Halonen, Ronald L. Gibson, Margaret Rosenfeld, Scott D. Sagel, Michael J. Bamshad, Wayne J. Morgan, Stefano Guerra

Publikováno v: Journal of Cystic Fibrosis. 21:811-820

Club cell secretory protein (CC16) exerts anti-inflammatory functions in lung disease. We sought to determine the relation of serum CC16 deficits and genetic variants that control serum CC16 to lung function among children with cystic fibrosis (CF).W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2c4fa611d2e548dbc25b7b60c9b097b
https://doi.org/10.1016/j.jcf.2022.03.007

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Akademický článek

Ultra-Sensitive TP53 Sequencing for Cancer Detection Reveals Progressive Clonal Selection in Normal Tissue over a Century of Human Lifespan

Autor: Jesse J. Salk, Kaitlyn Loubet-Senear, Elisabeth Maritschnegg, Charles C. Valentine, Lindsey N. Williams, Jacob E. Higgins, Reinhard Horvat, Adriaan Vanderstichele, Daniela Nachmanson, Kathryn T. Baker, Mary J. Emond, Emily Loter, Maria Tretiakova, Thierry Soussi, Lawrence A. Loeb, Robert Zeillinger, Paul Speiser, Rosa Ana Risques

Publikováno v: Cell Reports, Vol 28, Iss 1, Pp 132-144.e3 (2019)

Summary: High-accuracy next-generation DNA sequencing promises a paradigm shift in early cancer detection by enabling the identification of mutant cancer molecules in minimally invasive body fluid samples. We demonstrate 80% sensitivity for ovarian c

Externí odkaz: https://doaj.org/article/321fc6803f4e46e7a0f6986070caf555

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Supplementary Figures 1-12 from Mitochondrial DNA Mutations are Associated with Ulcerative Colitis Preneoplasia but Tend to be Negatively Selected in Cancer

Autor: Rosa Ana Risques, Scott R. Kennedy, Teresa A. Brentnall, Cigdem Ussakli, Mary J. Emond, Shilpa Kumar, Daniela Nachmanson, Kathryn T. Baker

Figure S1.Histology of UC colon tissue. Figure S2. Clonal expansions Figure S3. Clonal and Subclonal Mutations by Biopsy Figure S4. Association between mutation number and total DCS nucleotides sequenced. Figure S5. Association of Clonal and Subclona

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dba3d42f342225fb9e120899389b41b
https://doi.org/10.1158/1541-7786.22516372

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