Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Mary J Dunlop"'
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 7, p e1012276 (2024)
Dense arrangements of binding sites within nucleotide sequences can collectively influence downstream transcription rates or initiate biomolecular interactions. For example, natural promoter regions can harbor many overlapping transcription factor bi
Externí odkaz:
https://doaj.org/article/5db998e284a542f8b309c32335c5864b
Publikováno v:
eLife, Vol 12 (2024)
Molecular tools for optogenetic control allow for spatial and temporal regulation of cell behavior. In particular, light-controlled protein degradation is a valuable mechanism of regulation because it can be highly modular, used in tandem with other
Externí odkaz:
https://doaj.org/article/5eda0eb1cf29457e8509a9390a2a21d9
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 1, p e1009797 (2022)
Improvements in microscopy software and hardware have dramatically increased the pace of image acquisition, making analysis a major bottleneck in generating quantitative, single-cell data. Although tools for segmenting and tracking bacteria within ti
Externí odkaz:
https://doaj.org/article/cec53aeb977a44d086aac6257abee85d
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 4, p e1007673 (2020)
Microscopy image analysis is a major bottleneck in quantification of single-cell microscopy data, typically requiring human oversight and curation, which limit both accuracy and throughput. To address this, we developed a deep learning-based image an
Externí odkaz:
https://doaj.org/article/43f66c4119054e10ad86ea5b2f796c15
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 12, p e1006634 (2018)
Several key transcription factors have unusually short half-lives compared to other cellular proteins. Here, we explore the utility of active degradation in shaping how the multiple antibiotic resistance activator MarA coordinates its downstream targ
Externí odkaz:
https://doaj.org/article/cb4691567c0f482aa8e1069cb7fa7665
Autor:
Nicholas A Rossi, Mary J Dunlop
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 1, p e1005310 (2017)
Stress response networks frequently have a single upstream regulator that controls many downstream genes. However, the downstream targets are often diverse, therefore it remains unclear how their expression is specialized when under the command of a
Externí odkaz:
https://doaj.org/article/a4c91931fb884cb7bcb704fc94ecdc28
Autor:
Mary J Dunlop, Zain Y Dossani, Heather L Szmidt, Hou Cheng Chu, Taek Soon Lee, Jay D Keasling, Masood Z Hadi, Aindrila Mukhopadhyay
Publikováno v:
Molecular Systems Biology, Vol 7, Iss 1, Pp 1-7 (2011)
Abstract Many compounds being considered as candidates for advanced biofuels are toxic to microorganisms. This introduces an undesirable trade‐off when engineering metabolic pathways for biofuel production because the engineered microbes must balan
Externí odkaz:
https://doaj.org/article/6356178459af48d39123d8b50b6bf83e
Autor:
Marijke Frederix, Kimmo Hütter, Jessica Leu, Tanveer S Batth, William J Turner, Thomas L Rüegg, Harvey W Blanch, Blake A Simmons, Paul D Adams, Jay D Keasling, Michael P Thelen, Mary J Dunlop, Christopher J Petzold, Aindrila Mukhopadhyay
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e101115 (2014)
The ability to solubilize lignocellulose makes certain ionic liquids (ILs) very effective reagents for pretreating biomass prior to its saccharification for biofuel fermentation. However, residual IL in the aqueous sugar solution can inhibit the grow
Externí odkaz:
https://doaj.org/article/01c1a8544e5346e3a81ad8a3b514c9d4
Autor:
Javier Garcia-Bernardo, Mary J Dunlop
Publikováno v:
PLoS Computational Biology, Vol 9, Iss 9, p e1003229 (2013)
Cells live in uncertain, dynamic environments and have many mechanisms for sensing and responding to changes in their surroundings. However, sudden fluctuations in the environment can be catastrophic to a population if it relies solely on sensory res
Externí odkaz:
https://doaj.org/article/3a72ec832d004864a0f89be1f717a2e5
Publikováno v:
ACS Omega. 7:18331-18338
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0420cf6130aab52e42cde5bfdb27bcbd
https://doi.org/10.1021/acsomega.2c00483
https://doi.org/10.1021/acsomega.2c00483