Simultaneous Coinfection of Macaques with Zika and Dengue Viruses Does not Enhance Acute Plasma Viremia but Leads to Activation of Monocyte Subsets and Biphasic Release of Pro-inflammatory Cytokines

Autor: William G. Valiant, Mary J. Mattapallil, Stephen Higgs, Yan-Jang S. Huang, Dana L. Vanlandingham, Mark G. Lewis, Joseph J. Mattapallil

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)

Abstract The consequences of simultaneous infection with Zika (ZIKV) and Dengue (DENV) viruses are poorly understood. Here we show that rhesus macaques experimentally coinfected simultaneously with ZIKV and DENV-2 demonstrated ZIKV or DENV replicatio

Externí odkaz: https://doaj.org/article/98da3e2a93a84a69b1d1d0c93ea35080

A novel role for lipoxin A4 in driving a lymph node–eye axis that controls autoimmunity to the neuroretina

Autor: Jessica Wei, Mary J Mattapallil, Reiko Horai, Yingyos Jittayasothorn, Arnav P Modi, H Nida Sen, Karsten Gronert, Rachel R Caspi

Publikováno v: eLife, Vol 9 (2020)

The eicosanoid lipoxin A4 (LXA4) has emerging roles in lymphocyte-driven diseases. We identified reduced LXA4 levels in posterior segment uveitis patients and investigated the role of LXA4 in the pathogenesis of experimental autoimmune uveitis (EAU).

Externí odkaz: https://doaj.org/article/1478210c54f44cb39b611f01a50ed664

Gender differences in innate responses and gene expression profiles in memory CD4 T cells are apparent very early during acute simian immunodeficiency virus infection.

Autor: Jeffy George, Ryan C Johnson, Mary J Mattapallil, Lynnsey Renn, Ronald Rabin, D Scott Merrell, Joseph J Mattapallil

Publikováno v: PLoS ONE, Vol 14, Iss 9, p e0221159 (2019)

Gender differences in Human immunodeficiency virus (HIV) disease progression and comorbidities have been extensively reported. Using the simian immunodeficiency virus (SIV) infected rhesus macaque model, we show that these differences are apparent ve

Externí odkaz: https://doaj.org/article/b9dd614f8e2c4502846b7fc5898f9921

Gain-of-function mutations in

Autor: Christina Torres, Kozycki, Shilpa, Kodati, Laryssa, Huryn, Hongying, Wang, Blake M, Warner, Priyam, Jani, Dima, Hammoud, Mones S, Abu-Asab, Yingyos, Jittayasothorn, Mary J, Mattapallil, Wanxia Li, Tsai, Ehsan, Ullah, Ping, Zhou, Xiaoying, Tian, Ariane, Soldatos, Niki, Moutsopoulos, Marie, Kao-Hsieh, Theo, Heller, Edward W, Cowen, Chyi-Chia Richard, Lee, Camilo, Toro, Shelley, Kalsi, Zohreh, Khavandgar, Alan, Baer, Margaret, Beach, Debra, Long Priel, Michele, Nehrebecky, Sofia, Rosenzweig, Tina, Romeo, Natalie, Deuitch, Laurie, Brenchley, Eileen, Pelayo, Wadih, Zein, Nida, Sen, Alexander H, Yang, Gary, Farley, David A, Sweetser, Lauren, Briere, Janine, Yang, Fabiano, de Oliveira Poswar, Ida Vanessa D, Schwartz, Tamires, Silva Alves, Perrine, Dusser, Isabelle, Koné-Paut, Isabelle, Touitou, Salah Mohamed, Titah, Petrus Martin, van Hagen, Rogier T A, van Wijck, Peter J, van der Spek, Hiromi, Yano, Andreas, Benneche, Ellen M, Apalset, Ragnhild Wivestad, Jansson, Rachel R, Caspi, Douglas Byron, Kuhns, Massimo, Gadina, Hidetoshi, Takada, Hiroaki, Ida, Ryuta, Nishikomori, Elena, Verrecchia, Eugenio, Sangiorgi, Raffaele, Manna, Brian P, Brooks, Lucia, Sobrin, Robert B, Hufnagel, David, Beck, Feng, Shao, Amanda K, Ombrello, Ivona, Aksentijevich, Daniel L, Kastner, Rachel, Mahoney

Publikováno v: Annals of the rheumatic diseases. 81(10)

To test the hypothesis that ROSAH (retinal dystrophy, optic nerve oedema, splenomegaly, anhidrosis and headache) syndrome, caused by dominant mutation inThis cohort study systematically evaluated 27 patients with ROSAH syndrome for inflammatory featu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c3e3c21bd5ada9cddabd90227704b7ef
https://pubmed.ncbi.nlm.nih.gov/35868845

T cell-intrinsic role for Nod2 in protection against Th17-mediated uveitis

Autor: Bryce A. Binstadt, João M. Furtado, Michael P. Davey, Paige E. Snow, Biying Xu, Ruth J. Napier, Christina Lancioni, Kimberly A. Samson, Michelle C. Callegan, E. J. Lee, Mary J. Mattapallil, Holly L. Rosenzweig, Emily E. Vance, Sydney Lashley, Reiko Horai, Luke S. Uebelhoer, Brieanna Brown, Rachel R. Caspi, Richard K. Vehe, Justine R. Smith

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Nature Communications

Mutations in nucleotide-binding oligomerization domain-containing protein 2 (NOD2) cause Blau syndrome, an inflammatory disorder characterized by uveitis. The antimicrobial functions of Nod2 are well-established, yet the cellular mechanisms by which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b42c7e920b9a31c5f909265b99df89d
https://doaj.org/article/5c09fe5a329b4c398f56c7642549fe79