Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Mary Iconomou"'
Autor:
Connor P. O’Meara, Lucia Guerri, Divine-Fondzenyuy Lawir, Fernando Mateos, Mary Iconomou, Norimasa Iwanami, Cristian Soza-Ried, Katarzyna Sikora, Iliana Siamishi, Orlando Giorgetti, Sarah Peter, Michael Schorpp, Thomas Boehm
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-3 (2024)
Externí odkaz:
https://doaj.org/article/2d9bbcca1e134054a0f3d0eb9b35b848
Autor:
Connor P. O’Meara, Lucia Guerri, Divine-Fondzenyuy Lawir, Fernando Mateos, Mary Iconomou, Norimasa Iwanami, Cristian Soza-Ried, Katarzyna Sikora, Iliana Siamishi, Orlando Giorgetti, Sarah Peter, Michael Schorpp, Thomas Boehm
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-18 (2021)
Abstract To capture the global gene network regulating the differentiation of immature T cells in an unbiased manner, large-scale forward genetic screens in zebrafish were conducted and combined with genetic interaction analysis. After ENU mutagenesi
Externí odkaz:
https://doaj.org/article/336c81ef888e42abb79749a16438e1dd
Autor:
Thomas Boehm, Katarzyna Sikora, Sarah Peter, Connor P. O'Meara, Cristian Soza-Ried, Lucia Guerri, Fernando Mateos, Norimasa Iwanami, Divine-Fondzenyuy Lawir, Mary Iconomou, Orlando Bruno Giorgetti, Iliana Siamishi, Michael Schorpp
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-18 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-18 (2021)
To capture the global gene network regulating the differentiation of immature T cells in an unbiased manner, large-scale forward genetic screens in zebrafish were conducted and combined with genetic interaction analysis. After ENU mutagenesis, geneti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aedc248eb7c4af0d26564f8945e52ddd
https://doi.org/10.1038/s42003-021-02694-x
https://doi.org/10.1038/s42003-021-02694-x
Autor:
Martina Fröhlich, Gregor Warsow, Olaf Neumann, Benedikt Brors, Florian Weinberg, Stefan Fröhling, Viola Hollek, Dieter Henrik Heiland, Peter Horak, Hanno Glimm, Sandra Braun, Ricarda Griffin, Christoph Heining, Corinna Spohr, Wilko Weichert, Albrecht Stenzinger, Christof von Kalle, Tilman Brummer, Mary Iconomou, Barbara Hutter, Sebastian Uhrig, Michael Röring, David E. Reuss, Simon Kreutzfeldt
Publikováno v:
Oncogene. 39:814-832
Fusion proteins involving the BRAF serine/threonine kinase occur in many cancers. The oncogenic potential of BRAF fusions has been attributed to the loss of critical N-terminal domains that mediate BRAF autoinhibition. We used whole-exome and RNA seq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc0b67c280404689ddaa0b6fae1658c7
https://doi.org/10.1038/s41388-019-1021-1
https://doi.org/10.1038/s41388-019-1021-1
Autor:
Florian, Weinberg, Ricarda, Griffin, Martina, Fröhlich, Christoph, Heining, Sandra, Braun, Corinna, Spohr, Mary, Iconomou, Viola, Hollek, Michael, Röring, Peter, Horak, Simon, Kreutzfeldt, Gregor, Warsow, Barbara, Hutter, Sebastian, Uhrig, Olaf, Neumann, David, Reuss, Dieter Henrik, Heiland, Christof, von Kalle, Wilko, Weichert, Albrecht, Stenzinger, Benedikt, Brors, Hanno, Glimm, Stefan, Fröhling, Tilman, Brummer
Publikováno v:
Oncogene. 39(4)
Fusion proteins involving the BRAF serine/threonine kinase occur in many cancers. The oncogenic potential of BRAF fusions has been attributed to the loss of critical N-terminal domains that mediate BRAF autoinhibition. We used whole-exome and RNA seq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1339e88f8f968ee341c7e47ec2338845
https://pubmed.ncbi.nlm.nih.gov/31558800
https://pubmed.ncbi.nlm.nih.gov/31558800
Autor:
Benedikt Brors, Martina Fröhlich, Simon Kreutzfeldt, Wilko Weichert, Gregor Warsow, Barbara Hutter, Christoph Heining, Stefan Fröhling, Michael Röring, Florian Weinberg, Sandra Braun, Olaf Neumann, Ricarda Herr, David E. Reuss, Albrecht Stenzinger, Peter Horak, Dieter Hendrik Heiland, Sebastian Uhrig, Hanno Glimm, Viola Hollek, Christof von Kalle, Tilman Brummer, Corinna Spohr, Mary Iconomou
Publikováno v:
Molecular Cancer Therapeutics. 18:LB-B08
Fusion proteins involving the BRAF serine/threonine kinase occur in many cancers. Oncogenic BRAF fusion proteins usually consist of the BRAF kinase domain and an N-terminal fusion partner that replaces the critical domains required for BRAF autoinhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53006a573ae76e3482806cf930cc3523
https://doi.org/10.1158/1535-7163.targ-19-lb-b08
https://doi.org/10.1158/1535-7163.targ-19-lb-b08
Autor:
Sean P. Kennedy, Jeremy Z. R. Han, Mary Iconomou, Darren N. Saunders, Robert F. Shearer, Jordan F. Hastings, David R. Croucher
Publikováno v:
J Vis Exp
The assembly of protein complexes is a central mechanism underlying the regulation of many cell signaling pathways. A major focus of biomedical research is deciphering how these dynamic protein complexes act to integrate signals from multiple sources
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::196ed4bd54a3a7654312746d3af65cb9
https://europepmc.org/articles/PMC6101743/
https://europepmc.org/articles/PMC6101743/
Autor:
Andrew J. Hoy, Robert F. Shearer, Mary Iconomou, David Miller, Andrew V. Biankin, Marina Pajic, Leonid A. Sazanov, John V. Pearson, Mark J. Cowley, Mark Pinese, Darren N. Saunders, Nicola Waddell, Jessie McKenna, Seher Balaban, Nigel Turner, Rae-Anne Hardie, Ellen van Dam, Silas G. Villas-Boas, Ting-Li Han, Sean M. Grimmond
Publikováno v:
Cancer & Metabolism
Background Pancreatic cancer has a five-year survival rate of ~8%, with characteristic molecular heterogeneity and restricted treatment options. Targeting metabolism has emerged as a potentially effective therapeutic strategy for cancers such as panc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67ea2a302f9044663ba29e04e9c92369
https://eprints.gla.ac.uk/137229/1/137229.pdf
https://eprints.gla.ac.uk/137229/1/137229.pdf
Autor:
Yaowu He, Kevin C.N. Lau, Brittney S. Harrington, Yang Chen, John W. Lumley, James S. Palmer, John D. Hooper, Brian Meade, Mary Iconomou, Lez J. Burke
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 139
CUB domain containing protein 1 (CDCP1) is a transmembrane protein involved in progression of several cancers. When located on the plasma membrane, full-length 135 kDa CDCP1 can undergo proteolysis mediated by serine proteases that cleave after two a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::410dda0cbb8349c6a7de936520b1d95c
https://pubmed.ncbi.nlm.nih.gov/28279929
https://pubmed.ncbi.nlm.nih.gov/28279929
Autor:
Joseph Lau, Adrian Wan, Sean P. Kennedy, Samuel Aparicio, Darren N. Saunders, Robert F. Shearer, Jeremy Z. R. Han, Mary Iconomou, Jordan F. Hastings, David R. Croucher, Jessie McKenna
Publikováno v:
Science Signaling. 9
The dynamic assembly of multiprotein complexes is a central mechanism of many cell signaling pathways. This process is key to maintaining the spatiotemporal specificity required for an accurate, yet adaptive, response to rapidly changing cellular con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5687fc2430f7f0580086454158d6ff1
https://doi.org/10.1126/scisignal.aaf0793
https://doi.org/10.1126/scisignal.aaf0793