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Supplementary Figure S3 from Metastatic Melanoma Patient–Derived Xenografts Respond to MDM2 Inhibition as a Single Agent or in Combination with BRAF/MEK Inhibition

Autor: Ann Richmond, Anna E. Vilgelm, Douglas B. Johnson, Ana Grau, Mary Hooks, Rondi M. Kauffmann, Mark C. Kelley, Chi Yan, Gregory D. Ayers, Kimberly B. Dahlman, Vijaya Bharti, Caroline A. Nebhan, Rami Nayef Al-Rohil, Jamye F. O'Neal, Holly Crandall, Christopher Andrew Johnson, Emily Murray, Sheau-Chiann Chen, Rebecca L. Shattuck-Brandt

Supplementary Figure S3: Alterations in Protein Expression Associated with D+T Response in Group I PDX lines.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a615a26d692e75ec4c67385d90b7ac58
https://doi.org/10.1158/1078-0432.22468085.v1

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Table S1 from Metastatic Melanoma Patient–Derived Xenografts Respond to MDM2 Inhibition as a Single Agent or in Combination with BRAF/MEK Inhibition

Supplementary Table S1. A. NGS Summary.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c7faf68099ece8781e0a728803768d5
https://doi.org/10.1158/1078-0432.22468076.v1

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Supplementary Figure S5 from Metastatic Melanoma Patient–Derived Xenografts Respond to MDM2 Inhibition as a Single Agent or in Combination with BRAF/MEK Inhibition

Supplementary Figure S5: Association Between Mutation Status and t Ratio.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48d8986380b4bb12667a27ae057ce0e1
https://doi.org/10.1158/1078-0432.22468079

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Supplementary Figure S4 from Metastatic Melanoma Patient–Derived Xenografts Respond to MDM2 Inhibition as a Single Agent or in Combination with BRAF/MEK Inhibition

Supplementary Figure S4: Protein Expression Patterns Did Not Predict KRT-232 Responsiveness in Group III PDX lines Compared to Group II PDX Lines

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e60f94d018884455b8b3ae3a2f3f9247
https://doi.org/10.1158/1078-0432.22468082

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Data from Metastatic Melanoma Patient–Derived Xenografts Respond to MDM2 Inhibition as a Single Agent or in Combination with BRAF/MEK Inhibition

Purpose:Over 60% of patients with melanoma respond to immune checkpoint inhibitor (ICI) therapy, but many subsequently progress on these therapies. Second-line targeted therapy is based on BRAF mutation status, but no available agents are available f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::878b6ec941e09bff49ae82d864b61c19
https://doi.org/10.1158/1078-0432.c.6526829

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Supplementary Figure S2 from Metastatic Melanoma Patient–Derived Xenografts Respond to MDM2 Inhibition as a Single Agent or in Combination with BRAF/MEK Inhibition

Supplementary FigureS2: Response to KRT-232.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e1c504d7d3c4d2636f557e5692ff159
https://doi.org/10.1158/1078-0432.22468088

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Supplementary Figure S1 from Metastatic Melanoma Patient–Derived Xenografts Respond to MDM2 Inhibition as a Single Agent or in Combination with BRAF/MEK Inhibition

Supplementary Figure S1A: Validation of PDX tumors: Short Tandem Repeat (STR) Analysis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a66b9901652454a0f9b274d15b5d1c8
https://doi.org/10.1158/1078-0432.22468091

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Perturbation of red cell membrane structure during intracellular maturation of Plasmodium falciparum

Autor: Mary Hooks, Theodore F. Taraschi, Harvey Rubin, Aruna Parashar

Publikováno v: Science (New York, N.Y.). 232(4746)

An experimental approach, which in this study was applied to the malarial system, can be used to analyze the molecular structure and organization of individual phospholipids in a wide variety of biological membranes. Electron spin resonance spectrosc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::970f7db3f8351b93ca127826cceb56d9
https://pubmed.ncbi.nlm.nih.gov/3006251

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