Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Mary Hongying, Cheng"'
Publikováno v:
eLife, Vol 12 (2024)
The vesicular monoamine transporter 2 (VMAT2) is a proton-dependent antiporter responsible for loading monoamine neurotransmitters into synaptic vesicles. Dysregulation of VMAT2 can lead to several neuropsychiatric disorders including Parkinson’s d
Externí odkaz:
https://doaj.org/article/393c81c8a92d464781df40f53e029e46
Autor:
Hoang Nguyen, Mary Hongying Cheng, Ji Young Lee, Shaili Aggarwal, Ole Valente Mortensen, Ivet Bahar
Publikováno v:
Current Research in Physiology, Vol 7, Iss , Pp 100125- (2024)
Human monoamine transporters (MATs) are critical to regulating monoaminergic neurotransmission by translocating their substrates from the synaptic space back into the presynaptic neurons. As such, their primary substrate binding site S1 has been targ
Externí odkaz:
https://doaj.org/article/2dd442ed5c1e4971947f9e308ab3fdf1
Autor:
Xuan Zhang, Tina Weiß, Mary Hongying Cheng, Siqi Chen, Carla Katharina Ambrosius, Anne Sophie Czerniak, Kunpeng Li, Mingye Feng, Ivet Bahar, Annette G Beck-Sickinger, Cheng Zhang
Publikováno v:
PLoS Biology, Vol 21, Iss 12, p e3002188 (2023)
Chemokine-like receptor 1 (CMKLR1), also known as chemerin receptor 23 (ChemR23) or chemerin receptor 1, is a chemoattractant G protein-coupled receptor (GPCR) that responds to the adipokine chemerin and is highly expressed in innate immune cells, in
Externí odkaz:
https://doaj.org/article/3564aaff35224cb3be106e5a8988ac7e
Autor:
Chuan Chen, James W. Saville, Michelle M. Marti, Alexandra Schäfer, Mary Hongying Cheng, Dhiraj Mannar, Xing Zhu, Alison M. Berezuk, Anupam Banerjee, Michele D. Sobolewski, Andrew Kim, Benjamin R. Treat, Priscila Mayrelle Da Silva Castanha, Nathan Enick, Kevin D. McCormick, Xianglei Liu, Cynthia Adams, Margaret Grace Hines, Zehua Sun, Weizao Chen, Jana L. Jacobs, Simon M. Barratt-Boyes, John W. Mellors, Ralph S. Baric, Ivet Bahar, Dimiter S. Dimitrov, Sriram Subramaniam, David R. Martinez, Wei Li
Publikováno v:
iScience, Vol 25, Iss 8, Pp 104798- (2022)
Summary: The emergence of SARS-CoV-2 variants of concern (VOCs) requires the development of next-generation biologics with high neutralization breadth. Here, we characterized a human VH domain, F6, which we generated by sequentially panning large pha
Externí odkaz:
https://doaj.org/article/e9a8e86720ca420e9915a6296aa53a18
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Multisystem inflammatory syndrome in children (MIS-C) is a febrile pediatric inflammatory disease that may develop weeks after initial SARS-CoV-2 infection or exposure. MIS-C involves systemic hyperinflammation and multiorgan involvement, including s
Externí odkaz:
https://doaj.org/article/9d2a1635c46e42da826cee9dd68e7261
Autor:
Mary Hongying Cheng, James M. Krieger, Anupam Banerjee, Yufei Xiang, Burak Kaynak, Yi Shi, Moshe Arditi, Ivet Bahar
Publikováno v:
iScience, Vol 25, Iss 3, Pp 103939- (2022)
Summary: The emergence of SARS-CoV-2 variants necessitates rational assessment of their impact on the recognition and neutralization of the virus by the host cell. We present a comparative analysis of the interactions of Alpha, Beta, Gamma, and Delta
Externí odkaz:
https://doaj.org/article/688a6897c7d64964a3a8048ce0437b13
Autor:
Yonjung Kim, Ikhyun Jun, Dong Hoon Shin, Jihoon G. Yoon, He Piao, Jinsei Jung, Hyun Woo Park, Mary Hongying Cheng, Ivet Bahar, David C. Whitcomb, Min Goo Lee
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 1, Pp 79-103 (2020)
Backgraoud & Aims: Aberrant epithelial bicarbonate (HCO3−) secretion caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene is associated with several diseases including cystic fibrosis and pancreatitis. Dynamica
Externí odkaz:
https://doaj.org/article/c6eb1ab64573444889221934c2ae218e
Autor:
Tiziana Romanazzi, Daniele Zanella, Mary Hongying Cheng, Behrgen Smith, Angela M. Carter, Aurelio Galli, Ivet Bahar, Elena Bossi
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
Bile acids (BAs) are molecules derived from cholesterol that are involved in dietary fat absorption. New evidence supports an additional role for BAs as regulators of brain function. Sterols such as cholesterol interact with monoamine transporters, i
Externí odkaz:
https://doaj.org/article/b376f84050474feb8167b05631affcd4
Autor:
Fangyuan Chen, Qingya Shi, Fen Pei, Andreas Vogt, Rebecca A Porritt, Gustavo Garcia Jr, Angela C Gomez, Mary Hongying Cheng, Mark E Schurdak, Bing Liu, Stephen Y Chan, Vaithilingaraja Arumugaswami, Andrew M Stern, D Lansing Taylor, Moshe Arditi, Ivet Bahar
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 8, Pp n/a-n/a (2021)
Abstract Understanding the mechanism of SARS‐CoV‐2 infection and identifying potential therapeutics are global imperatives. Using a quantitative systems pharmacology approach, we identified a set of repurposable and investigational drugs as poten
Externí odkaz:
https://doaj.org/article/7db43c04a84b4afb9367c079ed650876
Autor:
Jenny I Aguilar, Mary Hongying Cheng, Josep Font, Alexandra C Schwartz, Kaitlyn Ledwitch, Amanda Duran, Samuel J Mabry, Andrea N Belovich, Yanqi Zhu, Angela M Carter, Lei Shi, Manju A Kurian, Cristina Fenollar-Ferrer, Jens Meiler, Renae Monique Ryan, Hassane S Mchaourab, Ivet Bahar, Heinrich JG Matthies, Aurelio Galli
Publikováno v:
eLife, Vol 10 (2021)
Parkinson disease (PD) is a progressive, neurodegenerative disorder affecting over 6.1 million people worldwide. Although the cause of PD remains unclear, studies of highly penetrant mutations identified in early-onset familial parkinsonism have cont
Externí odkaz:
https://doaj.org/article/a653b249c2a248ce98bd9707ad03c665