Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Mary H. Young"'
Autor:
Andrea M. Hanson, Mary H. Young, Brooke C. Harrison, Xiaolan Zhou, H. Q. Han, Louis S. Stodieck, Virginia L. Ferguson
Publikováno v:
npj Microgravity, Vol 9, Iss 1, Pp 1-11 (2023)
Abstract Novel treatments for muscle wasting are of significant value to patients with disease states that result in muscle weakness, injury recovery after immobilization and bed rest, and for astronauts participating in long-duration spaceflight. We
Externí odkaz:
https://doaj.org/article/9312246776294c9ca7f1d9de58b313bf
Autor:
Mary H. Young, Greg Pietz, Elizabeth Whalen, Wilbert Copeland, Ethan Thompson, Brian A. Fox, Kathryn J. Newhall
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract This study sought to understand how the programmed death ligand 1 (PD-L1) inhibitor durvalumab and the immunomodulatory agent pomalidomide regulate immune cell activation and function in patients with relapsed/refractory (RR) multiple myelom
Externí odkaz:
https://doaj.org/article/12984849fdd84a40badc86697ac75613
Autor:
Brian Fox, Ethan G. Thompson, Greg Pietz, Kathryn Newhall, Wilbert B. Copeland, Mary H. Young, Elizabeth Whalen
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports
Scientific Reports
This study sought to understand how the programmed death ligand 1 (PD-L1) inhibitor durvalumab and the immunomodulatory agent pomalidomide regulate immune cell activation and function in patients with relapsed/refractory (RR) multiple myeloma (MM). I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29e169708d1713d2df5b9e631e7c09f6
https://doaj.org/article/12984849fdd84a40badc86697ac75613
https://doaj.org/article/12984849fdd84a40badc86697ac75613
Autor:
Amrit P. Singh, Frank Schmitz, Adam Z. Rosenthal, Madhav V. Dhodapkar, Antje Hoering, Daisy Alapat, Yan Ren, Maurizio Zangari, Kelsie Smith, Samuel A. Danziger, Jake Gockley, Andrew Dervan, Alexander V. Ratushny, Mark McConnell, Robert M. Hershberg, Suzana Couto, Brian A Walker, Faith E. Davies, Alison Fitch, Wilbert B. Copeland, Gareth J. Morgan, Bart Barlogie, Phil Farmer, David J. Reiss, Brian Fox, Mary H. Young, Frits van Rhee, Cody Ashby, Katie Newhall, Nathan Petty, Michael A Bauer, Robert Z. Orlowski, Matthew Trotter
Publikováno v:
PLoS Medicine
PLoS Medicine, Vol 17, Iss 11, p e1003323 (2020)
PLoS Medicine, Vol 17, Iss 11, p e1003323 (2020)
Background The tumor microenvironment (TME) is increasingly appreciated as an important determinant of cancer outcome, including in multiple myeloma (MM). However, most myeloma microenvironment studies have been based on bone marrow (BM) aspirates, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aea307499ba8a6ddb4ca18327f4a1cfd
http://europepmc.org/articles/PMC8425547
http://europepmc.org/articles/PMC8425547
Autor:
Tuna Mutis, Sonja Zweegman, Meletios A. Dimopoulos, Mary H. Young, Kristine A. Frerichs, Christie P. M. Verkleij, Kathryn Newhall, Jhon A. Marin Soto, Niels W.C.J. van de Donk
Publikováno v:
Cancers, Vol 13, Iss 2452, p 2452 (2021)
Cancers
Frerichs, K A, Verkleij, C P M, Dimopoulos, M A, Marin Soto, J A, Zweegman, S, Young, M H, Newhall, K J, Mutis, T & van de Donk, N W C J 2021, ' Efficacy and safety of durvalumab combined with daratumumab in daratumumab-refractory multiple myeloma patients ', Cancers, vol. 13, no. 10, 2452 . https://doi.org/10.3390/cancers13102452
Cancers, 13(10):2452. Multidisciplinary Digital Publishing Institute (MDPI)
Volume 13
Issue 10
Cancers
Frerichs, K A, Verkleij, C P M, Dimopoulos, M A, Marin Soto, J A, Zweegman, S, Young, M H, Newhall, K J, Mutis, T & van de Donk, N W C J 2021, ' Efficacy and safety of durvalumab combined with daratumumab in daratumumab-refractory multiple myeloma patients ', Cancers, vol. 13, no. 10, 2452 . https://doi.org/10.3390/cancers13102452
Cancers, 13(10):2452. Multidisciplinary Digital Publishing Institute (MDPI)
Volume 13
Issue 10
Simple Summary The CD38-targeting antibody daratumumab has marked activity in multiple myeloma through direct anti-tumor effects and immunomodulatory activity. However, eventually most patients will develop daratumumab-refractory disease. We hypothes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcce53485707a8a28aa93c8e6ebcae9c
https://www.mdpi.com/2072-6694/13/10/2452
https://www.mdpi.com/2072-6694/13/10/2452
Autor:
Mary H Young, Lance U'Ren, Shouxiong Huang, Thierry Mallevaey, James Scott-Browne, Frances Crawford, Olivier Lantz, Ted H Hansen, John Kappler, Philippa Marrack, Laurent Gapin
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53789 (2013)
Mucosal-associated invariant T cells are a unique population of T cells that express a semi-invariant αβ TCR and are restricted by the MHC class I-related molecule MR1. MAIT cells recognize uncharacterized ligand(s) presented by MR1 through the cog
Externí odkaz:
https://doaj.org/article/ffbe0134aa6c4b8e9d6313e04ba00c8b
Autor:
Eric T Clambey, Bernard Collins, Mary H Young, Jens Eberlein, Alexandria David, John W Kappler, Philippa Marrack
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57435 (2013)
The Ikaros family of transcription factors is critical for normal T cell development while limiting malignant transformation. Mature CD8 T cells express multiple Ikaros family members, yet little is known about their function in this context. To test
Externí odkaz:
https://doaj.org/article/1a2a32c056b147608c4943d1c861a41a
Autor:
Tiffany Khong, Samuel E Norton, John V. Reynolds, William E. Pierceall, Malarmathy Ramachandran, Mary H. Young, Udo Oppermann, Andrew Spencer, Manman Guo, Anjan Thakurta, Anna Kalff
Publikováno v:
Blood. 136:34-35
The LEOPARD trial evaluated lenalidomide and alternate day prednisolone (RAP) as post ASCT maintenance in newly diagnosed transplant eligible MM patients (TE NDMM). 60 patients were recruited. Estimated median potential follow-up was 44 months (IQR 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8db55d2229ddc3897d1bff1ad31062cf
https://doi.org/10.1182/blood-2020-141746
https://doi.org/10.1182/blood-2020-141746
Autor:
Shradha Srinivasan, David Kuo, David J. Reiss, Mary H. Young, Jason A. Dubovsky, Vanessa E. Gray, Kathryn Newhall, Trevor Do, Frank Schmitz, Falon D. Gray, N. Eric Olson, Suzana Couto, Brian Fox, Chung-Wein Lee
Publikováno v:
Blood. 134:202-202
Background: The availability of chimeric antigen receptor (CAR)-modified T cells (CAR T) has profoundly increased therapeutic options for patients (pts) with B cell malignancies, including DLBCL. Liso-cel is an investigational, anti-CD19, defined com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e831fb177a56ae67e6aee19d9297318a
https://doi.org/10.1182/blood-2019-127683
https://doi.org/10.1182/blood-2019-127683
Publikováno v:
Muscle & Nerve. 48:393-402
Introduction Hindlimb unloading-induced muscle atrophy is often assessed after a homeostatic state is established, thus overlooking the early adaptations that are critical to developing this pattern of atrophy. Methods Muscle function and physiology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d80af77dc5f043de0cecb28c24585027
https://doi.org/10.1002/mus.23753
https://doi.org/10.1002/mus.23753