Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Mary Gleason-Guzman"'
Publikováno v:
Molecular Cancer Therapeutics. 7:3617-3623
Resistance to chemotherapy reduces its effectiveness, resulting in increased mortality. Psorospermin, a natural product, is a topoisomerase II–directed DNA alkylating agent active against multidrug-resistant (MDR) cell lines, including multiple mye
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24f4d6d66b1a8d755bd9daef179e91cc
https://doi.org/10.1158/1535-7163.mct-08-0519
https://doi.org/10.1158/1535-7163.mct-08-0519
Autor:
Michael K. Schwaebe, Laurence H. Hurley, Thomas S. Dexheimer, Mary Gleason-Guzman, Ingrid M. Fellows, Jeffrey P. Whitten, Hariprasad Vankayalapati
Publikováno v:
Molecular Cancer Therapeutics. 4:1729-1739
Psorospermin is a natural product that has been shown to have activity against drug-resistant leukemia lines and AIDS-related lymphoma. It has also been shown to alkylate DNA through an epoxide-mediated electrophilic attack, and this alkylation is gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b04f7e7ccffa30b85bfa32cd57fe9f09
https://doi.org/10.1158/1535-7163.mct-05-0183
https://doi.org/10.1158/1535-7163.mct-05-0183
Autor:
Mary Gleason-Guzman, Adam Siddiqui-Jain, Hariprasad Vankayalapati, Robert A. Heald, Lajos Szabo, Laurence H. Hurley, Thomas S. Dexheimer
Publikováno v:
Journal of Medicinal Chemistry. 48:2993-3004
The antileukemic xanthone psorospermin is a topoisomerase II-dependent DNA alkylator in advanced preclinical development. Efforts have been made to further understand the structural requirements of its mechanism of action through the synthesis of rin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b9a9570bcb23fc48fa066e44b10df41
https://doi.org/10.1021/jm049299c
https://doi.org/10.1021/jm049299c
Autor:
Mary Gleason-Guzman, Caroline N. Waltmire, Harris Bernstein, Bernard W. Futscher, Mary T. Craven, Harinder S. Garewal, Katerina Dvorakova, Cheray Crowley, George S. Watts, Claire M. Payne, Cara L. Crowley-Weber, Carol Bernstein
Publikováno v:
Carcinogenesis. 23:2063-2080
Evidence from live cell bioassays shows that the flat mucosa from patients with colon cancer exhibits resistance to bile salt-induced apoptosis. Three independent cell lines derived from the colonic epithelial cell line HCT-116 were selected for resi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f30dc5b77e8e6713e382c66b7f066896
https://doi.org/10.1093/carcin/23.12.2063
https://doi.org/10.1093/carcin/23.12.2063
Autor:
George S. Watts, Mary Gleason-Guzman, Monika Schmelz, Bernard W. Futscher, Jean Barrera, Mark Fitchmun, Anne E. Cress, Raymond B. Nagle, Junshan Hao, Robert Isett, Robert Calaluce, G. Tim Bowden, Mark Kunkel
Publikováno v:
Molecular Carcinogenesis. 30:119-129
Interactions between extracellular matrix (ECM) proteins and prostate carcinoma cells provide a dynamic model of prostate tumor progression. Previous work in our laboratory showed that laminin-5, an important member of a family of ECM glycoproteins e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b7966b59e9e85fc3e3794d6d4f4f6f2
https://doi.org/10.1002/1098-2744(200102)30:2<119::aid-mc1020>3.0.co
https://doi.org/10.1002/1098-2744(200102)30:2<119::aid-mc1020>3.0.co
Publikováno v:
Blood. 89:1854-1861
Recent evidence has supported the hypothesis that chemotherapeutic drugs and radiation induce an apoptotic pathway that requires the active participation of the cell. One pathway of apoptosis in malignant lymphoid cells is mediated by the Fas antigen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be246de3393b0081f99ca872db47cbb5
https://doi.org/10.1182/blood.v89.6.1854
https://doi.org/10.1182/blood.v89.6.1854
Publikováno v:
International Journal of Cancer. 66:506-514
Inhibitors of P-glycoprotein (P-gp) or chemosensitizers, such as verapamil, are used to reverse multi-drug resistance (MDR) in cancer patients. Clinical studies in patients with myeloma have shown that some patients with P-gp-positive cancer cells re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bde4df14c7cc5ca2c8ade3635ac984d
https://doi.org/10.1002/(sici)1097-0215(19960516)66:4<506::aid-ijc14>3.0.co
https://doi.org/10.1002/(sici)1097-0215(19960516)66:4<506::aid-ijc14>3.0.co
Autor:
Mary Gleason-Guzman, Bernard W. Futscher, William S. Dalton, Nils E. Foley, Paul S. Meltzer, Daniel M. Sullivan
Publikováno v:
International Journal of Cancer. 66:520-525
Selection protocols were designed to determine whether non-cytotoxic chemomodifiers can influence the evolution of the drug-resistant phenotype. To this end, the human multiple myeloma cell line RPMI 8226 (8226/S) was selected with either doxorubicin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1897051af850a2d3a1b317c66b84fb8a
https://doi.org/10.1002/(sici)1097-0215(19960516)66:4<520::aid-ijc16>3.0.co
https://doi.org/10.1002/(sici)1097-0215(19960516)66:4<520::aid-ijc16>3.0.co
Autor:
Mary Gleason-Guzman, Denise Tye, Jessica S. Fortin, Laurence H. Hurley, Yong Qin, Tracy A. Brooks
Publikováno v:
Biochemistry. 49(19)
To understand the mechanisms controlling platelet-derived growth factor receptor beta (PDGFR-beta) expression in malignancies, we have cloned and characterized the first functional promoter of the human PDGFR-beta gene, which has been confirmed by lu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15c48ae6d9c8f16933dd3a062948f1d2
https://pubmed.ncbi.nlm.nih.gov/20377208
https://pubmed.ncbi.nlm.nih.gov/20377208
Autor:
Cory L. Grand, David J. Bearss, Mary Gleason-Guzman, Raymond B. Nagle, Laurence H. Hurley, Denise Tye, Tiffanie J. Powell
We have demonstrated that a parallel G-quadruplex structure in the c- MYC promoter functions as a transcriptional repressor element. Furthermore, a specific G-to-A mutation in this element results in destabilization of the G-quadruplex repressor elem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e249838946a78053d53ce8563d88f64c
https://europepmc.org/articles/PMC395936/
https://europepmc.org/articles/PMC395936/
