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Akademický článek

Modeling normal mouse uterine contraction and placental perfusion with non-invasive longitudinal dynamic contrast enhancement MRI.

Autor: Devin Raine Everaldo Cortes, Margaret C Stapleton, Kristina E Schwab, Dalton West, Noah W Coulson, Mary Gemmel O'Donnell, Anthony G Christodoulou, Robert W Powers, Yijen L Wu

Publikováno v: PLoS ONE, Vol 19, Iss 7, p e0303957 (2024)

BackgroundThe placenta is a transient organ critical for fetal development. Disruptions of normal placental functions can impact health throughout an individual's entire life. Although being recognized by the NIH Human Placenta Project as an importan

Externí odkaz: https://doaj.org/article/3fb8375ff68140f5918d8cd439c3c7cc

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Akademický článek

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Akademický článek

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Pre-pregnancy stress induces maternal vascular dysfunction during pregnancy and postpartum

Autor: Mary Gemmel O’Donnell, Lauren Stumpp, Marcia J. Gallaher, Robert W. Powers

Publikováno v: Reproductive Sciences.

An estimated 20% of women suffer from a stress-related mood disorder including depression and anxiety during and after pregnancy, making these disorders among the most common complications of pregnancy. These stress-related disorders are associated w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::70dd8f1b132de6989b1ab2478916c752
https://doi.org/10.1007/s43032-023-01248-2

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Nitric oxide signaling in pregnancy and preeclampsia

Autor: Robert W. Powers, Mary Gemmel, Elizabeth F. Sutton

Publikováno v: Nitric Oxide. 95:55-62

While the etiology of preeclampsia continues to be elucidated, it is clear that preeclampsia is a complex obstetrical syndrome associated with maternal vascular dysfunction within which impairments in nitric oxide (NO) signaling likely play a key rol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92c2dcdaa5d2655eebe3529b461fd80c
https://doi.org/10.1016/j.niox.2019.11.006

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Investigation of a Paternal-Mediated Preeclampsia-Like Pregnancy Phenotype Mouse Model

Autor: Marcia J. Gallaher, Lauren Burnette, Robert W. Powers, Mary Gemmel

Publikováno v: Pittsburgh Undergraduate Review. 1

Preeclampsia, a pregnancy specific syndrome characterized by new onset hypertension and proteinuria, is a leading cause of maternal and neonatal morbidity and mortality. While no animal model perfectly mimics the human syndrome, breeding C1q-/- (male

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b8d5a1a4ef6d18f7bf2058c46b578c98
https://doi.org/10.5195/pur.2021.15

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l-Citrulline supplementation during pregnancy improves perinatal and postpartum maternal vascular function in a mouse model of preeclampsia

Autor: Marcia J. Gallaher, Judith Brands, Lauren Burnette, Elizabeth F. Sutton, Mary Gemmel, Robert W. Powers

Publikováno v: American journal of physiology. Regulatory, integrative and comparative physiology. 321(3)

Preeclampsia is a spontaneously occurring pregnancy complication diagnosed by new-onset hypertension and end-organ dysfunction with or without proteinuria. This pregnancy-specific syndrome contributes to maternal morbidity and mortality and can have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a73b839577872bd791ae67ec0954711
https://pubmed.ncbi.nlm.nih.gov/34259017

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Paternal deficiency of complement component C1q leads to a preeclampsia-like pregnancy in wild-type female mice and vascular adaptations postpartum

Autor: Marcia J. Gallaher, Robert W. Powers, Mary Gemmel, Judith Brands, Elizabeth F. Sutton

Publikováno v: American journal of physiology. Regulatory, integrative and comparative physiology. 318(6)

Preeclampsia is a spontaneously occurring, pregnancy-specific syndrome that is clinically diagnosed by new onset hypertension and proteinuria. Epidemiological evidence describes an association between a history of preeclampsia and increased risk for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ea5d2687d8cd70e5cc529b7e8db025a
https://pubmed.ncbi.nlm.nih.gov/32374620

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