Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Mary G. Banoub"'
Publikováno v:
EBioMedicine, Vol 53, Iss , Pp - (2020)
Antiretroviral therapy (ART) suppresses human immunodeficiency virus (HIV) infection. Research seeking to transform viral suppression into elimination has generated novel immune, chemical and molecular antiviral agents. However, none, to date, have e
Externí odkaz:
https://doaj.org/article/4e2416340179418f88dc464b1d8bfb63
Autor:
Nagsen Gautam, Howard E. Gendelman, Melinda Wojtkiewicz, Bhagya Laxmi Dyavar Shetty, Mary G. Banoub, JoEllyn M McMillan, Denise A. Cobb, Yazen Alnouti, Aditya N. Bade, Zhiyi Lin, Benson J Edagwa
Publikováno v:
Mol Pharm
Antiretroviral therapy (ART) has improved the quality of life in patients infected with HIV-1. However, complete viral suppression within anatomical compartments remains unattainable. This is complicated by adverse side effects and poor adherence to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4737896724017f5fae35bebe8d7b114
https://doi.org/10.1021/acs.molpharmaceut.9b00871
https://doi.org/10.1021/acs.molpharmaceut.9b00871
Autor:
Santhi Gorantla, James R. Hilaire, Won Bin Young, Shohreh Amini, JoEllyn M McMillan, Brady Sillman, Chen Chen, Hang Su, Mary G. Banoub, Kamel Khalili, Howard E. Gendelman, Prasanta K. Dash, Jennifer Gordon, Larisa Y. Poluektova, Nagsen Gautam, Martina Donadoni, Rahsan Sariyer, Pietro Mancuso, Saumi Mathews, Rafal Kaminski, Monalisha Elango, R. Lee Mosley, Tricia H. Burdo, Jeffrey M. Jacobson, Benson J Edagwa, Taha Mohseni Ahooyi, Pasquale Ferrante, Jake A. Robinson, Zhiyi Lin, Ramona Bella, Ilker Kudret Sariyer, Aditya N. Bade
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-20 (2019)
Nature Communications
Nature Communications
Elimination of HIV-1 requires clearance and removal of integrated proviral DNA from infected cells and tissues. Here, sequential long-acting slow-effective release antiviral therapy (LASER ART) and CRISPR-Cas9 demonstrate viral clearance in latent in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b27b73c3e4c0b82ed8decf5430a2d869
https://doaj.org/article/ad4b010214414d8c84777d8ae90f684b
https://doaj.org/article/ad4b010214414d8c84777d8ae90f684b
Autor:
Howard E. Gendelman, Yazen Alnouti, Nagsen Gautam, Nathan Smith, JoEllyn M McMillan, Audai Maayah, Mary G. Banoub, Zhiyi Lin
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 153:248-259
Nucleoside reverse transcriptase inhibitors (NRTIs) require intracellular phosphorylation to active triphosphate (TP) nucleotide metabolites before they can inhibit the HIV reverse transcriptase. However, monitoring these pharmacologically active TP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f69b394b298ec9b5d1cf6a773b84f0bc
https://doi.org/10.1016/j.jpba.2018.02.036
https://doi.org/10.1016/j.jpba.2018.02.036
Autor:
Samuel M. Cohen, Rolen M. Quadros, Raghubendra Singh Dagur, Edward Makarov, Weimin Wang, JoEllyn M McMillan, Mary G. Banoub, Poonam S. Joshi, Zhiyi Lin, Amanda Branch Woods, Santhi Gorantla, Ted Kocher, Denise A. Cobb, Donald W. Harms, Larisa Y. Poluektova, Howard E. Gendelman, Channabasavaiah B. Gurumurthy
Publikováno v:
The Journal of Pharmacology and Experimental Therapeutics
Antiretroviral drug (ARV) metabolism is linked largely to hepatic cytochrome P450 activity. One ARV drug class known to be metabolized by intestinal and hepatic CYP3A are the protease inhibitors (PIs). Plasma drug concentrations are boosted by CYP3A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5325aec11b7d09cf0d23c8d8de5f78c
https://pubmed.ncbi.nlm.nih.gov/29476044
https://pubmed.ncbi.nlm.nih.gov/29476044
Autor:
Howard E. Gendelman, Mary G. Banoub
Publikováno v:
Neuroimmune Pharmacology ISBN: 9783319440200
The mononuclear phagocyte (MP; monocyte, macrophages, dendritic cells and microglia) is part of innate immunity that functions by nonspecific surveillance and clearing response through phagocytic and intracellular killing activities. MPs included are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::896bcf0a3c013bf1499510f79317ab2a
https://doi.org/10.1007/978-3-319-44022-4_11
https://doi.org/10.1007/978-3-319-44022-4_11
Publikováno v:
JAIDS Journal of Acquired Immune Deficiency Syndromes. 77:55-55
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0cf85c0615668a45e9c57441defb843
https://doi.org/10.1097/01.qai.0000532495.71417.5c
https://doi.org/10.1097/01.qai.0000532495.71417.5c