Morphoproteomics, E6/E7 in-situ hybridization, and biomedical analytics define the etiopathogenesis of HPV-associated oropharyngeal carcinoma and provide targeted therapeutic options

Autor: Robert E. Brown, Syed Naqvi, Mary F. McGuire, Jamie Buryanek, Ron J. Karni

Publikováno v: Journal of Otolaryngology - Head and Neck Surgery, Vol 46, Iss 1, Pp 1-8 (2017)

Abstract Background Human papillomavirus (HPV) has been identified as an etiopathogenetic factor in oropharyngeal squamous cell carcinoma. The HPV E6 and E7 oncogenes are instrumental in promoting proliferation and blocking differentiation leading to

Externí odkaz: https://doaj.org/article/c40aa3488394433c87e8fb56484af030

Disruption of thrombo-inflammatory response and activation of a distinct cytokine cluster after subarachnoid hemorrhage

Autor: Suhas Bajgur, Georgene W. Hergenroeder, Spiros Blackburn, Jude P.J. Savarraj, Huimahn A Choi, Liang Zhu, Dong H. Kim, Mary F. McGuire, Kaushik Parsha, Tiffany R. Chang, Elena Espino, Pramod K. Dash, Sungho Ahn

Publikováno v: Cytokine. 111:334-341

Background Unregulated inflammatory and thrombotic responses have been proposed to be important causes of early brain injury and worse clinical outcomes after subarachnoid hemorrhage (SAH). Objective We hypothesize that SAH is characterized by an inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6803cc33acf29f6300d0b0edffee5a58
https://doi.org/10.1016/j.cyto.2018.09.003

Abstracts of Presentations at the Association of Clinical Scientists 139

Autor: Keri, Donaldson, Jeanine M, Buchanich, Patricia Sue, Grigson, Erin, Deneke, Kent E, Vrana, David B, Sacks, Gregory J, Kuehn, David, Cardamone, Amadeo, Pesce, Sarah, Smiley, Joyce, Nickley, Kevin, Krock, Richard, Thomas, Myra L, Wilkerson, Hosam A, Farag, Sashi Rameswara, Challa, Ann Marie, Tice, Donna M, Wolk, Jeffrey, Prichard, Michelle L, Grant, Sandeep, Regmi, Brian, Kerbacher, Lawrence E, Quinton, A M, Tice, Jordan, Olson, Amanda, Haynes, Elsie, Yu, Kilmer S, McCully, Jasmeet, Assi, Myra, Wong, Neda, Zarrin-Khameh, Thomas P, Nifong, Charles D, Hawker, George T, Carlton, Julia M, Rivera, Philip R, Foulis, Aleksandra, Zuraw, Diana, Morlote, Deniz, Peker, Vishnu, Reddy, Shuko, Harada, Chris, Crutchfield, Dani, Zander, Mustafa A, Barbhuiya, Edward C, Pederson, Monica L, Straub, Sofia C, Scott, Terri L, Neibauer, Wayne F, Salter, Michael H, Creer, Yusheng, Zhu, Joshua A, Bornhorst, J Paul, Theobald, Alicia, Algeciras-Schimnich, Liyun, Cao, James, Knox, Robert, Hardy, Hicks J, Texas, Mary F, McGuire, Robert L, Hunter, Robert E, Brown, John, Hicks, Zhenjian, Cai, Yasir, Ali, Keith C, Cheng, Spencer R, Katz, Yifu, Ding, Daniel J, Vanselow, Maxsim A, Yakovlev, Alex Y, Lin, Darin P, Clark, Phillip, Vargas, Xuying, Xin, Jean E, Copper, Victor A, Canfield, Khai C, Ang, Yuxin, Wang, Xianghui, Xiao, Francesco, De Carlo, Damian B, van Rossum, Patrick J, La Rivière, Jordan, Newell, Carrie, Hossler, Michael, Roche, Joshua, Warrick, Rebecca, Phaeton, Josh, Kesterson, Charlotte, Myers, Roberto, Barrios, Paul, Mintz, Kimberly, Robyak, Christopher, Hamilton, Pamela, McGhee, Christopher, Pederson, Monica, Straub, Sofia, Scott, Terri, Neibauer, Wayne, Salter, Michael, Creer, Nirupama, Singh, Cindy, Vnencak-Jones, Anna, Yemelyanova, Mauli, Shah, Soheil Zorofchian, Moghadamtousi, Chieh, Lan, Dzifa, Duose, Peter, Hu, Yoshua, Esquenazi, Rajyalakshmi, Luthra, Leomar Y, Ballester, Annie N, Koenig, Chang-Gong, Liu, Jianhua, Zhang, Awdhesh, Kalia, Ali, Al-Habib, Melissa, Van Arsdall, Sadhna, Dhingra, Kalyani, Patel, Nina, Tatevian

Publikováno v: Annals of clinical and laboratory science. 49(3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4ecb713bc4ad1a7bcd5fe8f93421b64e
https://pubmed.ncbi.nlm.nih.gov/31308044

Contributors

Autor: Jeffrey K. Actor, Joseph L. Alcorn, Jammie Barnes, Michael R. Blackburn, Shivika Chandra, Huimahn A. Choi, Jacob P. Couturier, Wasim A. Dar, Amitava Dasgupta, Shen-An Hwang, Ryan S. Kitagawa, Marian L. Kruzel, Mark Kruzel, Dorothy E. Lewis, Mary F. McGuire, Nicholas Parchim, Kemly Philip, Jude P.J. Savarraj, Mya C. Schiess, Keri C. Smith, Jessika Suescun, Peter Vanderslice, Darren G. Woodside, Yang Xia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d5ebe2c315f19ed7904af2c7ad1e0d98
https://doi.org/10.1016/b978-0-12-813832-8.09992-1

Morphoproteomics and Biomedical Analytics Identify the c-Myc, EZH2, Sirt1 and CXCR4 Pathways as Potential Blocks to Differentiation Leading to Proliferation and Metastatic Potential in Sinonasal Undifferentiated Carcinoma (SNUC) and Provide Therapeutic Options: A Case Study

Autor: Robert E, Brown, Suvra, Roy, Mary F, McGuire

Publikováno v: Annals of clinical and laboratory science. 48(5)

Sinonasal undifferentiated carcinoma (SNUC) is a highly malignant tumor in the nasal cavity or paranasal sinuses. Morphoproteomics has defined its biology to some degree, allowing the identification of targeted therapeutic options with clinical effic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::01b287fa799310ca357669bc30d284e3
https://pubmed.ncbi.nlm.nih.gov/30373873