Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Mary F. Kanz"'
Publikováno v:
Toxicology Letters. 169:13-25
Methylenedianiline (DAPM) is considered a cholangiodestructive toxicant in vivo. Increases in biliary inorganic phosphate (P(i)) and glucose occur prior to biliary epithelial cell (BEC) injury, which could be due to increased paracellular permeabilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::792f6955884ca798220bd1e8e0496cc7
https://doi.org/10.1016/j.toxlet.2006.11.007
https://doi.org/10.1016/j.toxlet.2006.11.007
Autor:
Mary F. Kanz, Mary Treinen-Moslen
Publikováno v:
Pharmacology & Therapeutics. 112:649-667
Drug secretion into bile is typically considered a safe route of clearance. However, biliary delivery of some drugs or their reactive metabolites to the intestinal tract evokes adverse consequences due to direct toxic actions or indirect disruption o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::327e7ba9197dbef41e0c863e50b25456
https://doi.org/10.1016/j.pharmthera.2006.05.007
https://doi.org/10.1016/j.pharmthera.2006.05.007
Publikováno v:
Journal of Chromatography B. 830:231-237
A rapid and sensitive high-performance liquid chromatographic method was developed for determination of diclofenac and its major metabolite, 4'-hydroxydiclofenac, in serum from rats treated with diclofenac. The method is simple with a one-step extrac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac0f4cd265b17b8ee6d12aa833ec1154
https://doi.org/10.1016/j.jchromb.2005.10.045
https://doi.org/10.1016/j.jchromb.2005.10.045
Publikováno v:
Toxicological Sciences. 84:129-138
Methylenedianiline (DAPM) rapidly injures biliary epithelial cells (BEC) in vivo. Prior to evident BEC injury, biliary glucose and inorganic phosphate appreciably rise, which could stem from loosened tight junctions (TJ). Concurrently, ultrastructura
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f15acd9bb8da1aa01c54c11ca06762a9
https://doi.org/10.1093/toxsci/kfi061
https://doi.org/10.1093/toxsci/kfi061
Publikováno v:
Toxicological Sciences. 74:447-456
Methylenedianiline (DAPM) initially injures epithelial cells of major bile ducts, which is followed by cholestasis, cholangitis, and hepatocellular damage. This pattern of biliary injury resembles that produced by alpha-naphthylisothiocyanate (ANIT),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::786b8903bf71eb85335128eeafd3be08
https://doi.org/10.1093/toxsci/kfg125
https://doi.org/10.1093/toxsci/kfg125
Publikováno v:
Comments on Toxicology. 9:229-249
MRP2, a multidrug resistance-associated protein, helps to maintain mammalian homeostasis by exporting bilirubin conjugates and many xenobiotics into bile or urine. Experiments with two mutant rat strains, namely TR− and EHBR which have a functional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23d42f739b5e9bf33d19a67ff7945a56
https://doi.org/10.1080/08865140390427454
https://doi.org/10.1080/08865140390427454
Publikováno v:
Experimental and Molecular Pathology. 61:1-15
We studied the effects of a transient elevation in biliary pressure on biliary glutathione and amino acids in rats. Other biliary solutes monitored were total bile salt, Pi, which is a putative marker of paracellular leakage, and glucose, which is re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::393e6143d94228aff137b207d32edbcc
https://doi.org/10.1006/exmp.1994.1021
https://doi.org/10.1006/exmp.1994.1021
Publikováno v:
Toxicology and Applied Pharmacology. 117:88-97
4,4'-Methylene dianiline (4,4'-diaminodiphenylmethane, DAPM), which is used in the polymer industry, causes hepatobiliary damage in exposed humans. Our objectives were to characterize the acute toxicity of DAPM in liver, particularly on secretion of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35677e13e1659d3e5772cf8e9c563f0b
https://doi.org/10.1016/0041-008x(92)90221-d
https://doi.org/10.1016/0041-008x(92)90221-d
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 27:7-15
Biliary output of endogenous and exogenous compounds is altered by anesthesia, depletion of bile salts, and hydrostatic pressure. The described system for bile function studies minimizes these confounding factors by substantially modifying existing m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d6100538392f10fc95b458c7df89866
https://doi.org/10.1016/1056-8719(92)90014-r
https://doi.org/10.1016/1056-8719(92)90014-r
Publikováno v:
Toxicology. 70:213-229
Our objective was to determine if the previously reported protective effect of hypothyroidism against 1,1-dichloroethylene hepatotoxicity was associated with a change in distribution and covalent binding. Sprague-Dawley male rats were made hypothyroi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afdfcb7dab8c6ee7fc5cf2062d9b386f
https://doi.org/10.1016/0300-483x(91)90048-6
https://doi.org/10.1016/0300-483x(91)90048-6