Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Mary F. Fitzgerald"'
Autor:
Gabriele Matschiner, Mary F. Fitzgerald, Ulrich Moebius, Andreas M. Hohlbaum, Hendrik Gille, Kristian Jensen, Klaus Kirchfeld, Barbara Rattenstetter, Alice Laforge, Rachida S. Bel Aiba, Joe Ciccotosto, Hong Nyugen, Martyn L. Foster, John N. Snouwaert, MyTrang Nguyen, Beverly H. Koller, Louis Matis, Gary P. Anderson, Shane A. Olwill
Publikováno v:
The Journal of allergy and clinical immunology.
T2 endotype asthma is driven by IL-4 and IL-13 signaling via IL-4Ra, which is highly expressed on airway epithelium, airway smooth muscle and immunocytes in the respiratory mucosa, suggesting potential advantages of an inhalable antagonist. Lipocalin
Autor:
Lara Hatchuel, Ingmar Bruns, Marita Olsson, David Close, Philip Gardiner, Mary F. Fitzgerald, Cyrus Ghobadi, Katerina Pardali, Mei Tsung, Lena Axelsson, Kristi Mclendon, George Mensing, Oscar Walsh, David J. Keeling, Nicholas Farinola
Publikováno v:
Airway pharmacology and treatment.
AZD1402/PRS-060 is a novel inhaled Anticalin® molecule antagonizing IL-4Ra. A multiple ascending dose clinical study (NCT03574805) was conducted in mild asthmatics (fractional exhaled nitric oxide (FeNO) levels ≥ 35ppb), to assess the safety, tole
Autor:
Ingmar Bruns, Close David, Gardiner Philip, Mary F. Fitzgerald, Lickliter Jason, Keeling David, Katerina Pardali, Jiang Fanyi, Axelsson Lena
Publikováno v:
Airway pharmacology and treatment.
AZD1402/PRS-060 is a novel inhaled Anticalin® molecule that antagonizes the IL-4 receptor alpha (IL-4Ra). A first-in-human study in healthy subjects was conducted to assess the safety, tolerability and pharmacokinetics (PK) of inhaled single ascendi
Autor:
Graham Dr Sturton, Mary F. Fitzgerald
Publikováno v:
Chest. 121:192S-196S
Phosphodiesterase 4 (PDE4) is a major cyclic adenosine-3',5'-monophosphate-metabolizing enzyme in immune and inflammatory cells, airway smooth muscle, and pulmonary nerves. Selective inhibitors of this enzyme have been available for a number of years
Autor:
Klaus Mohrs, Umesh P. Patel, Francis Hilary P, Nigel J. Cuthbert, Mary F. Fitzgerald, A. M. Thompson, Tracey G. Carpenter, Reiner Muller-Peddinghaus, Benjamin B Newton, William A. Taylor, P. J. Gardiner
Publikováno v:
European Journal of Pharmacology. 258:95-102
BAY x1005 (( R )-2-[4-quinolin-2-yl-methoxy)phenyl]-2-cyclopentyl acetic acid), an inhibitor of leukotriene synthesis, was evaluated, both in vitro and in vivo, for inhibition of antigen-induced airway contraction in the sensitised guinea-pig. Antige
Autor:
Andrew A. Protter, Ann M. Kapoun, Linda S. Higgins, Satyanarayana Medicherla, Dianne Spicer, Sarvajit Chakravarty, Jing Y. Ma, Mary F. Fitzgerald, Sundeep Dugar, Paul Woodman
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 324(3)
Chronic obstructive pulmonary disease (COPD) is characterized by pulmonary inflammation, which is relatively insensitive to inhaled corticosteroids. The extent of the pulmonary inflammation in COPD correlates with disease severity, and it is thought
Autor:
David A Campbell, Mary F Fitzgerald
Publikováno v:
Pharmacogenomics. 4(3)
Etiologics is an innovative drug discovery company that, unlike most new companies in this sector, has a balanced portfolio of ethylnitrosourea (ENU) technology, animal models of disease, in vitro cell function models, and expertise in drug discovery
Autor:
Carmen Demattos, Sarah V. Culpitt, Peter J. Barnes, Mary F. Fitzgerald, Andrew J. Thorley, Richard Russell, Louise E. Donnelly, Sara Dodd
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 283(4)
Chronic obstructive pulmonary disease (COPD) is a common lung disease with cigarette smoking as the major etiological factor, but only 15% of smokers develop COPD. Destruction of lung elastin observed in COPD is mediated by many enzymes, including cy
The release of platelet-activating factor (Paf-acether) and of its inactive precursor/metabolite lyso-platelet activating factor (lyso-Paf) from control and sensitized guinea-pig isolated lungs challenged with antigen was investigated. Control guinea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04dc521159c3e3522875e705b9f97f5d
https://europepmc.org/articles/PMC1917123/
https://europepmc.org/articles/PMC1917123/
Publikováno v:
European journal of pharmacology. 164(3)
Adherent guinea-pig alveolar macrophages stimulated in vitro with FMLP (1 μM) for 5–60 min released PAF-acether, TXB 2 and LTB 4 , with maximal levels being achieved after a 5 min incubation. The levels of eicosanoids were maintained during the 60