Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Mary F, Webb"'
Evidence That Hypothalamic Gliosis Is Related to Impaired Glucose Homeostasis in Adults With Obesity
Autor:
Mary Rosalynn B. De Leon, Stefan Schoen, Ellen A. Schur, Kristina M. Utzschneider, Madelaine Humphreys, Susan J. Melhorn, Jennifer L. Rosenbaum, Mary F. Webb
Publikováno v:
Diabetes Care
OBJECTIVE Preclinical research implicates hypothalamic glial cell responses in the pathogenesis of obesity and type 2 diabetes (T2D). In the current study we sought to translate such findings to humans by testing whether radiologic markers of gliosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a3bda2e87f728a6e28413cb02a7481a
https://doi.org/10.2337/dc21-1535
https://doi.org/10.2337/dc21-1535
Autor:
Mary F. Webb, Mary Rosalynn B. De Leon, Kristina M. Utzschneider, Susan J. Melhorn, Ellen A. Schur, Jennifer L. Rosenbaum, Stefan Schoen
Publikováno v:
Diabetes. 70
Studies demonstrate evidence of gliosis in the mediobasal hypothalamus (MBH) of people with obesity and T2D or impaired glucose tolerance (IGT), but whether MBH gliosis predicts worsening glucose homeostasis is unknown. The study evaluated 38 subject
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f533b96b4faafe731d2233f01d61605
https://doi.org/10.2337/db21-170-or
https://doi.org/10.2337/db21-170-or
Autor:
Susan J. Melhorn, Leticia E. Sewaybricker, Mary Rosalynn B. De Leon, Mary F. Webb, Jennifer L. Rosenbaum, Ellen A. Schur, Suchitra Chandrasekaran
Publikováno v:
Diabetes. 69
Gliosis, a cellular response to injury in neural tissue, is linked to diet-induced obesity in rodent models. Growing evidence also implicates reactive gliosis and inflammation of the mediobasal hypothalamus (MBH) as a potential mechanism connecting o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e96d2d40d84261a52687a0fdf3b9f5d
https://doi.org/10.2337/db20-151-or
https://doi.org/10.2337/db20-151-or
Autor:
Susan J. Melhorn, Mary F. Webb, Christian L. Roth, Jun Hua, Ellen A. Schur, Afroditi Papantoni, Susan Carnell, Leticia E. Sewaybricker
Publikováno v:
Pediatr Obes
OBJECTIVE Quantitative magnetic resonance imaging (MRI) evidence of mediobasal hypothalamic (MBH) gliosis positively correlates with body mass index (BMI) in adults. This has neither been well explored in children nor have other brain regions involve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ca2b9b07ac836110b6e30e16ae643d2
https://pubmed.ncbi.nlm.nih.gov/33084253
https://pubmed.ncbi.nlm.nih.gov/33084253
Autor:
Mary K. Askren, Mary Rosalynn B. De Leon, Mary F. Webb, Leticia E. Sewaybricker, Susan J. Melhorn, Vidhi Tyagi, William W. Seeley, Thomas J. Grabowski, Ellen A. Schur
Publikováno v:
International journal of obesity (2005), vol 44, iss 1
International journal of obesity (2005)
International journal of obesity (2005)
Background/objectivesThe salience network (SN) comprises brain regions that evaluate cues in the external environment in light of internal signals. We examined the SN response to meal intake and potential genetic and acquired influences on SN functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::522de7883c2f6156ac616b64aaf84c53
https://escholarship.org/uc/item/9n93525r
https://escholarship.org/uc/item/9n93525r
Autor:
Katya B. Rubinow, Mary Rosalynn B. De Leon, Stephanie T. Page, John K. Amory, Mary F. Webb, Ellen A. Schur, Susan J. Melhorn, Brett T. Marck, Kathryn E. Berkseth, Alvin M. Matsumoto
Publikováno v:
Obesity. 26:1898-1904
OBJECTIVE This study aimed to determine whether a relationship was evident between gliosis in the mediobasal hypothalamus (MBH) and plasma testosterone concentrations in men. METHODS A total of 41 adult men (aged 18-50 years) from 23 twin pairs under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::883fc270e9e545df2fd0ccea8eceb17c
https://doi.org/10.1002/oby.22324
https://doi.org/10.1002/oby.22324
Autor:
Mary K. Askren, Vidhi Tyagi, Susan J. Melhorn, Mary Rosalynn B. De Leon, Mario Kratz, Rudolph L. Leibel, Tyler A. Bosch, Wendy K. Chung, Thomas J. Grabowski, Mary F. Webb, Ellen A. Schur
Publikováno v:
The American Journal of Clinical Nutrition. 107:145-154
BACKGROUND: Variants in the first intron of the fat mass and obesity-associated (FTO) gene increase obesity risk. People with “high-risk” FTO genotypes exhibit preference for high-fat foods, reduced satiety responsiveness, and greater food intake
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86e0794968a9479a593e2a308f0ee094
https://doi.org/10.1093/ajcn/nqx029
https://doi.org/10.1093/ajcn/nqx029
Autor:
Ellen A. Schur, Mary F. Webb, Vidhi Tyagi, Susan J. Melhorn, Jennifer L. Rosenbaum, Mary K. Askren, Leticia E. Sewaybricker, Thomas J. Grabowski, Mary Rosalynn B. De Leon
Publikováno v:
Physiol Behav
BACKGROUND: Neuroimaging studies suggest that appetitive drive is enhanced in obesity. OBJECTIVE: To test if appetitive drive varies in direct proportion to the level of body adiposity after accounting for genetic factors that contribute to both brai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::030f90ed55859ddd200f356304fb34f0
https://doi.org/10.1016/j.physbeh.2021.113504
https://doi.org/10.1016/j.physbeh.2021.113504
Autor:
Mary Rosalynn B. De Leon, Vidhi Tyagi, Thomas J. Grabowski, Susan J. Melhorn, Ellen A. Schur, Mary F. Webb, Mary K. Askren, Leticia E. Sewaybricker
Publikováno v:
Diabetes. 68
Functional connectivity (fc) in the Salience Network (SN) is reduced by a meal. We hypothesized that disengagement of the SN may be mirrored by increased fc in Executive Control (ECN) or Default Mode (DMN) networks (representing a switch away from in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3e9179d1710d6f1352d9fb34915f21c
https://doi.org/10.2337/db19-2092-p
https://doi.org/10.2337/db19-2092-p
Autor:
Susan J. Melhorn, Kenneth R. Maravilla, Ellen A. Schur, Vidhi Tyagi, Sonya Mehta, Carolyn Noonan, Jack Goldberg, Mary F. Webb, Dedra Buchwald, Mario Kratz, Thomas J. Grabowski
Publikováno v:
The American Journal of Clinical Nutrition. 103:314-322
Background: Neural responses to highly energetic food cues are robust and are suppressed by eating. It is not known if neural responsiveness to food cues is an inherited trait and possibly even one that mediates the genetic influences on body weight
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c27438ff1691a3528821e9963393ad97
https://doi.org/10.3945/ajcn.115.121095
https://doi.org/10.3945/ajcn.115.121095